Tumor antigens for liver cancer immunotherapy

ABSTRACT

The present invention relates to tumor antigens and their use in cancer immunotherapy. In particular, the present invention relates to HERV epitopes and tumor associated antigens (TAAs) expressed by liver cancer cells and which, preferably in combination with epigenetic drugs, can be used in tumor vaccination therapies in the treatment and prevention of liver cancer, preferably hepatocellularcarcinoma (HCC).

TECHNICAL FIELD

The present invention relates to tumor antigens and their use in cancerimmunotherapy. In particular, the present invention relates to HERVepitopes and tumor associated antigens (TAAs) expressed by liver cancercells and which, preferably in combination with epigenetic drugs, can beused in tumor vaccination therapies in the treatment and prevention ofliver cancer, preferably hepatocellularcarcinoma (HCC) .

BACKGROUND

Cancer immunotherapy can be classified into passive and activestrategies, the latter being specific or non-specific [1]. Passive or“adoptive” immunotherapy is based on the administration of anticancerantibodies or the transfer of tumor reactive lymphocytes. Activeimmunotherapy is aimed both at stimulating a de novo specific immuneresponse in the host against selected tumor antigens, using therapeuticanti-cancer vaccines, and at amplifying the existing anti-tumor immuneresponse, by administering non-specific pro-inflammatory molecules oradjuvants. In this context, considering the disappointing resultsobtained so far with these strategies, the search for specific andselective tumor antigens for the development of tumor vaccines is themain objective for several research groups and leading companies in thehealth sector.

In this perspective, the search for human tumor antigens as potentialtargets for cancer immunotherapy has led to the discovery of severalmolecules mainly or selectively expressed on cancer cells. In fact, onlyin this way can the tumor antigens used in vaccines be able to breakimmune tolerance, without inducing pathological autoimmune sidereactions [2,3].

Tumor antigens are distinguished into Tumor associated antigens (TAAs)and Tumor specific antigens (TSAs). Antigens derived from the aberrantlyoverexpressed self-antigens in tumor cells compared to normal cells aredefined as tumor-associated antigens (TAAs) and might representuniversal antigens among patients with the same malignancy. Besides theoverexpressed antigens, TAAs can include: cell lineage differentiationantigens, which are normally not expressed in adult tissue; andcancer/germline antigens (also known as cancer/testis), which arenormally expressed only in immune privileged germline cells [Buonaguro &Tagliamonte, Selecting Target Antigens for Cancer Vaccine Development.Vaccines (Basel). 2020 Oct 17;8(4):615. doi: 10.3390/vaccines8040615,PMID: 33080888]. Overexpressed and tissue differentiation antigens areable to induce an antitumor immune response when high levels ofexpression of these proteins reach the threshold for T cell recognition,breaking immunological tolerance. One of the possible limitations ofTAAs is that they can also be present on normal cells, albeit with lowlevels of expression and, consequently, they can be subject to bothcentral and peripheral immune tolerance mechanisms [4]. Therefore,peptide analogs should be designed by substituting one or two amino acidresidues in the epitope sequence to improve its antigenicity andimmunogenicity [5].

On the other hand, TSAs are antigens present only on cancer cellsbecause they derive from specific biological processes of the neoplasticprocess. A particular group of TSAs are neoantigens resulting fromcancer-related non-synonymous mutations or other genetic alterationsthat result in mutated peptides presented by the human leukocyte antigen(HLA) on the cell surface to the immune system. Neoantigens aretheoretically the most interesting therapeutic targets because they aredifferent from the germ line and seen as “non self” by the immunesystem. Consequently, immune reactions directed towards neoantigens arenot subject to central and peripheral tolerance [6]. However, suchmutated neoantigens are strictly individual (private) and theiridentification requires a combination of genomic, proteomic andimmunomic screening procedures that currently cannot be applied on alarge scale [7-9]. Furthermore, the effectiveness of such a highlypersonalized approach is probably reduced by the high mutational rate oftumors which determines the constant generation of new target mutatedneoantigens and a consequent immune evasion of the cancer.

A different category of TSAs includes antigens derived from thetranscription of endogenous retrovirus (HERV) genes. In fact, HERVs,although they represent about 8% of the entire cellular genome, arenormally transcriptionally inactive. Hence, their antigens areconsidered non-self by our immune system and are not subject to thephenomenon of immune tolerance [10]. Consequently, TSAs derived fromHERVs, compared to those derived from mutations, would have theessential advantage of not being personalized because they are sharedamong all patients affected by the same oncological pathology or bydifferent oncological pathologies in which the same HERV are expressed[11].

Retroviruses are RNA viruses that replicate through a DNA intermediateand permanently integrate into a host’s genome. After initialintegration, the provirus is also capable of retrotransposition, whichhas the effect of amplifying the copy number (100-1000) of the provirusin the host genome. Such proviruses can become incompetent forreplication due to the accumulation of deletions and nonsense mutationswithin the viral genome. In this way, the provirus fixes itself in thehuman genome and the “endogenized” retroviruses are no longer able tocause horizontal infection of another host and are reclassified as HERV.In addition to acquiring large deletions and mutations within theproviral genome, HERVs undergo transcriptional silencing through DNAmethylation and the remodeling of chromatin [12].

There are approximately 40 independent and phylogenetically distinctgroups of HERVs categorized in the human genome [13]. Studies are stillunderway to understand whether HERVs play an active role in the onset orprogression of cancer or if they are the result of a secondary effect ofepigenetic change within the tumor cell [14]. In general, it is likelythat the differential regulation of HERV in cancer cells is a result ofthe global genomic instability of tumors that leads to DNAhypomethylation and chromatin remodeling. Such epigenetic changes canexpose and make available the Long Terminal Repeats (LTRs) of HERVs,which are normally transcriptionally silent, resulting in increasedtranscription and translation of retroviral genes [15].

Although HERVs are no longer competent for replication, they can havesignificant effects on transcription levels of cellular genes andoncogenic pathways by inserting LTRs near proto-oncogenes [16]. Indeed,it has been shown that HERV proteins interact with other cytosolicproteins including zinc fingers motifs on tumor suppressor genes [17]and are involved in tumor immune evasion [18]. Furthermore, HERVproteins are also immunogenic, as demonstrated by a significantactivation of the adaptive immune response against HERVs proteins intumor tissue and in the serum of cancer patients.

It is reported in the literature that the treatment of tumor cells withepigenetic drugs, such as DNA methyltransferase inhibitors or histonedeacetylase inhibitors, deregulates the cellular transcriptionalpattern, with the activation of different genes, including those ofHERV, which are normally inactive. This effect is not evident in normalcells because they are not actively replicating.

Consequently, the transcriptional activation induced by treatment withepigenetic drugs induces in tumor cells the expression of a broadspectrum of “neo-antigens” (antigens not normally expressed by cells)deriving both from the sequences of the HERV genes (gag, pol, env) andby the cellular gene sequences regulated by HERV LTRs. The secondcategory of genes is not predictable due to the random insertion of LTRsinto the genome, and therefore would be patient specific neo-antigens.On the other hand, the neoantigens deriving from the sequences of theHERV genes can represent an optimal target shared among all patientsaffected by the same oncological pathology or among all patientsaffected by different oncological pathologies in which the same HERV areexpressed [11].

Different classes of HERV have been associated with differentoncological diseases for which they can play a role both as potentialtumor markers and as immunological targets. Breast cancer and melanomaare the cancers for which there is the strongest experimental evidence,but documented evidence is also available on the role of HERV activityin colorectal cancer, pancreatic cancer, hepatocellular cancer, prostatecancer and ovarian cancer [19]. As for liver cancer, the only work inthe literature describes the expression of HERV-K (HML-2) which appearsto be correlated with the prognosis of the disease [20].

Among the cancers listed above, hepatocellular carcinoma (HCC) is thethird leading cause of cancer death globally. The age-standardizedincidence rate (ASR) of HCC in men in Europe, adjusted for the standardEuropean population, is approximately 8 in 100,000(http://globocan.iarc.fr/). Chronic infection with hepatitis B and Cvirus (HBV and HCV) is the main risk factor for the development of HCC[21].

HCC therapies depend on the stage of the disease with an extremelyvariable 5-year survival rate [22]. Surgery is the standard treatmentfor HCC in the early stages with a 5-year survival rate of 70% amongtreated patients [23,24]. Non-surgical loco-regional therapies areimplemented for HCC patients who show more advanced disease, withsurvival rates ranging from 3 to 5 years [25] and tumor recurrence inmore than 50% of patients at 5 years post treatment [25]. 26]. Sorafeniband Lenvatinib represent the only approved systemic therapy in advancedunresectable HCC, which provides a very limited survival benefit [27].Recently, the RESORCE study (Regorafenib after Sorafenib in patientswith hepatocellular carcinoma) demonstrated that Regorafenib can be usedas a second-line treatment in patients with advanced liver cancer whohave not responded to sorafenib treatment. Although the study showedonly a modest 2.8-month improvement in overall survival, with a 38%reduction risk of death, this was the first study to show the benefitsof second-line treatment in HCC [28]. In such a scenario, immunotherapystrategies for HCC may represent a key therapeutic tool for improvingclinical outcome in patients with hepatocellular carcinoma. Inparticular, therapeutic cancer vaccines could hold great promise. Thisis still an open field of research, given that only very few studies onthe HCC cancer vaccine have been conducted so far with still modestresults [29]. WO2014/004385 provides tumor-associated antigens and theiruse as vaccines for treating and limiting cancers in a patient. Inspecific aspects, HERV type K envelope proteins and peptides areprovided. Such proteins and peptides can be used to elicit specificimmune responses, both humoral and cellular, that target tumor cellsexpressing the HERV type K envelope protein. HERV-K derived antigens arealso disclosed in WO2020/049169 as tumor antigens for cancer vaccine.

In the light of the foregoing, the need for new anticancer therapies andcompounds capable of overcoming the disadvantages of known therapies andcompounds appears evident.

DESCRIPTION OF THE INVENTION

According to the present invention, new tumor associated antigens (TAAs)as well as new tumor-specific antigens (TSAs) have now been identified.The antigens of the present invention show the advantage of not beingstrictly specific for a single patient, but of being shared among allpatients affected by the same oncological pathology, in the specificcase hepatocellular carcinoma (HCC).

The antigens, and in particular the epitopes, according to the presentinvention, are able to bind the molecules of MHC (majorhistocompatibility complex), in particular HLA. Specifically, accordingto the present invention, TAAs and HERV TSAs have been identifiedcapable of binding MHC, more specifically HLA and, more specifically,different types of class I HLA.

As described in the experimental part, the specific TAAs and HERV TSAsassociated with different class I HLAs according to the presentinvention were identified by means of an antigenic prediction analysisfor the most frequent class I HLAs in the world population (carried outwith the algorithm NetMHCPan http://www.cbs.dtu.dk/services/NetMHCpan/).

According to the present invention, the HERV TSAs and the TAAsidentified can be advantageously used in anti-tumor vaccine therapies,also in combination with epigenetic drugs. In short, the administrationof a vaccine comprising one or more peptides according to the presentinvention would have the effect of stimulating the immune system againstsuch peptides. Subsequently, the administration of an epigenetic drugwould induce a reprogramming of the transcriptional and translationalprofile of the tumor cell, inducing the expression of these epitopes bythe tumor cell, which would then be readily recognized by the immunesystem with consequent effective elimination by the vaccine-inducedantitumor immunity.

Advantageously, according to the present invention, peptides as such, orpeptides in optimized forms, such as for example fused to antibodiescapable of recognizing antigen presenting cells (APC), such as dendriticcells, can be administered as a vaccine. Peptides can be administered inalternative forms, such as for example nucleic acids coding for saidpeptides, or vectors comprising said nucleic acids or directly to cells,for example APC, which express the peptides.

Furthermore, according to the present invention, said epitopes orpeptides can advantageously be used to stimulate T cells ex vivo andthen re-infuse said T cells in the patient either after theadministration of the epigenetic drug or in the absence of any specificpre-treatment.

Finally, according to the present invention it is possible to administera T cell engineered to express a receptor (CAR-T cell) capable ofrecognizing tumor-specific antigens expressed either following theadministration of an epigentic drug or in the absence of any specificany pre-treatment.

DESCRIPTION OF THE INVENTION

The present invention relates to a composition comprising at least onepeptide or at least one expression vector that induces the expression ofsaid at least one peptide, said peptide consisting of an amino acid (aa)sequence from 9 to 30 aa residues and comprising or consisting of atleast one of the epitopes sequences selected from: MLAGNAFTA (SEQ ID NO.119), ALMAFTSAV (SEQ ID NO. 120), DYFRNQFKI (SEQ ID NO. 121), MLAGNEFQV(SEQ ID NO. 108), TMLNILALV (SEQ ID NO. 109), YYYQRALEI (SEQ ID NO.110), KITEYLERV (SEQ ID NO. 111), VYSACSFTF (SEQ ID NO. 112), TLLKVTLEV(SEQ ID NO. 113), LYSGTAADF (SEQ ID NO. 114), MVMSFVNLV (SEQ ID NO.115), FYFRNHFCI (SEQ ID NO. 116), LLNQQICPV (SEQ ID NO. 117), VYVAFSEFF(SEQ ID NO. 118), and a pharmaceutically acceptable vehicle orexcipient.

Preferably said at least one of the epitopes sequences is selected from:MLAGNAFTA (SEQ ID NO. 119), ALMAFTSAV (SEQ ID NO. 120), DYFRNQFKI (SEQID NO. 121).

The invention also provides the a composition as defined above furthercomprising or expressing at least one peptide, said peptide consistingof an aa sequence of 9 to 30 aa and comprising or consisting of at leastone of the epitopes sequences selected from: ALLALTSAV (SEQ ID NO. 122),ALSNHLNAV (SEQ ID NO. 123), RQYSVGFEV (SEQ ID NO. 124), IYTVSSFSI (SEQID NO. 125), IFNIIPSTF (SEQ ID NO. 126), YYDVIYLSW (SEQ ID NO. 127),RIVCLFWGV (SEQ ID NO. 128), LYACGTGAF (SEQ ID NO. 129), FMLDLYNAL (SEQID NO. 130), FLISIYQVL (SEQ ID NO. 131), FQFSASLHV (SEQ ID NO. 132),VYTYIQSRF (SEQ ID NO. 133), VHMKDFFYF (SEQ ID NO. 134), ALFGALFLA (SEQID NO. 135), LLNSLLDTV (SEQ ID NO. 136), TYFGSIVLL (SEQ ID NO. 137),LYHAGTVLL (SEQ ID NO. 138), LLLTLLLLL (SEQ ID NO. 139), LLGPLLVLL(SEQ IDNO. 140).

Preferably the above composition further comprises or expresses at leastone peptide, said peptide consisting of an aa sequence of 9 to 30 aa andcomprising or consisting of at least one of the epitopes sequencesselected from: FINSGAWQI (SEQ ID NO.17), KLTTWILPK (SEQ ID NO.43),KTKIFQFLK (SEQ ID NO. 50), PYMLVVGNI (SEQ ID NO. 65), SMDDQLNQL (SEQ IDNO. 83), WQIGLANFV (SEQ ID NO. 96).

Still preferably the above composition further comprises or expresses atleast one peptide of 9 to 30 aminoacids comprising or consisting of atleast one of the epitopes sequences selected from SEQ ID NO. 4-16, SEQID NO. 18-42, SEQ ID NO. 44-49, SEQ ID NO. 51-64, SEQ ID NO. 66-82, SEQID NO. 84-95 and SEQ ID NO. 97-107.

In a preferred embodiment the invention relates to a composition asdefined above comprising or consisting of:

-   a. at least one of the epitopes sequences selected from: MLAGNAFTA    (SEQ ID NO. 119), ALMAFTSAV (SEQ ID NO. 120), DYFRNQFKI (SEQ ID NO.    121); and-   b. at least one of the epitopes sequences selected from: MLAGNEFQV    (SEQ ID NO. 108), TMLNILALV (SEQ ID NO. 109), YYYQRALEI (SEQ ID NO.    110), KITEYLERV (SEQ ID NO. 111), VYSACSFTF (SEQ ID NO. 112),    TLLKVTLEV (SEQ ID NO. 113), LYSGTAADF (SEQ ID NO. 114), MVMSFVNLV    (SEQ ID NO. 115), FYFRNHFCI (SEQ ID NO. 116), LLNQQICPV (SEQ ID NO.    117), VYVAFSEFF (SEQ ID NO. 118); and-   c. at least one of the epitopes sequences selected from: FINSGAWQI    (SEQ ID NO.17), KLTTWILPK (SEQ ID NO.43), KTKIFQFLK (SEQ ID NO. 50),    PYMLVVGNI (SEQ ID NO. 65), SMDDQLNQL (SEQ ID NO. 83), WQIGLANFV (SEQ    ID NO. 96).

Preferably the at least one peptide of the invention consists of anamino acid (aa) sequence from 9 to 30 aa residues, preferably 9 to 20,more preferably 9 aa residues.

The invention further relates to an engineered cell comprising arecombinant protein, or a polynucleotide encoding a recombinant protein,preferably said recombinant protein being a recombinant receptor, morepreferably a receptor expressed on the surface of the immune cellreceptor preferably, wherein the recombinant receptor specifically bindsto at least one peptide of the composition as described above,preferably wherein the recombinant receptor is a recombinant T cellreceptor (TCR) or a chimeric antigen receptor (CAR).

The composition according to the present invention is for use in thetreatment of cancer, preferably for use in the treatment or preventionof liver cancer, even more preferably for use in the treatment orprevention of hepatocellular carcinoma. Preferably said composition alsois administered in combination with an anticancer therapeutic agent.Preferably said anticancer therapeutic agent is an epigenetic drugand/or a check point inhibitor; more preferably an epigenetic drug.

The invention further provides a vaccine or immunogenic compositioncomprising the composition as defined above and a pharmaceuticallyacceptable vehicle or excipient and preferably an adjuvant. Preferablysaid vaccine or immunogenic composition is for use in the treatment orprevention of cancer, preferably for use in the treatment or preventionof liver cancer, even more preferably for use in the treatment orprevention of hepatocellular carcinoma.

It is a further object of the invention an isolated peptide selectedfrom the group consisting of the peptides having aa sequences selectedfrom SEQ ID NO. 4-140 or from the group of the peptides having an aasequence of 9 to 30 aa and comprising at least one of SEQ ID NO 108-140,characterized in that said isolated peptide is able to bind MHC class Iand/or MHC class II.

According to the invention, an “expression vector” that induces theexpression of a peptide comprises a nucleic acid, DNA or RNA, coding forthe peptide. The vector may be a RNA vector, a DNA vector, a viralvector or a bacterial vector.

According to the invention the term “peptide” includes peptide variantsretaining the ability to bind to MHC class I and/or MHC class IImolecule, for example peptides having one or two amino acids substitutedby amino acids belonging to the same group.

As further example peptides of the invention have sequence homology ofat least 80%, preferably at least 90%, with respect to the sequence ofone or more peptides, comprising or consisting of an amino acid sequencechosen from the sequences from SEQ ID NO: 4 to SEQ ID NO: 107 or fromSEQ ID NO: 108 to SEQ ID NO: 140 and retain the ability to binding MHCclass I and / or MHC class II.

In particular, when the peptide comprising or consisting of an aminoacid sequence chosen from the sequences from SEQ ID NO: 4 to SEQ ID NO:107 or from SEQ ID NO: 108 to SEQ ID NO: 140 is linked to class I MHC,the peptide is able to be recognized by T cells, in particular by CD8 Tcells. Or, when the above binds MHC class II is bound to MHC class II,the peptide is able to be recognized by TCD4 + cells (T helper cells).

A further example of “variant” relates to a peptide wherein a givenamino acid is altered by modifying it with the side chain of anothernaturally occurring amino acid residue or some other side chain, suchthat the peptide is still able to bind to an MHC class I or class IImolecule in substantially the same way as a peptide consisting of thegiven amino acid sequence in consisting of SEQ ID NO: 4 to SEQ ID NO:140. For example, a peptide may be modified so that it at leastmaintains, if not improves, the ability to interact with and bind to thebinding groove of a suitable MHC molecule.

Furthermore, the composition of the invention comprises or expresses asingle peptide as defined above, or a combination of some or all of thepeptides, variants, or a mixture of at least two of the peptides andvariants mentioned above, or at least three of the peptides mentionedabove. Preferably said mixture comprises or consists of at least threepeptides, wherein one peptide is an HERV epitope (Table 3) comprising orconsisting of anyone of SEQ ID NO.17, SEQ ID NO.43, SEQ ID NO. 50, SEQID NO. 65, SEQ ID NO. 83, SEQ ID NO. 96; one peptide is a tumorassociated antigens (TAAs) derived from the 9 overexpressed proteinsassociated with poor prognosis in HCC (Table 7) and comprising orconsisting of anyone of SEQ ID NO. 108-118; and one peptide is one ofthe peptides selected from a broad range of human viruses as sharinghigh homology with those derived from the HCC proteins (Table 8) andcomprising or consisting of anyone of SEQ ID. NO. 119 - 121.

As previously indicated, the composition of the invention comprisespeptides with a length from 9 amino acids to 30 amino acids, preferablyfrom 9 amino acids to 20 amino acids, more preferably of 9 amino acids.

In detail, the peptides of 9 amino acids are optimal for binding the MHCof class I, while to bind the MHC of class II the peptides must be of atleast 15 amino acids, preferably 20-30 amino acids. Advantageously, whenthe peptide according to the present invention or the peptides accordingto the present invention are able to bind MHC of class II, the latterhave a length of at least 15 amino acids, preferably from 20 amino acidsto 30 amino acids.

As used herein MHC class II indicates HLA class II, preferably HLA-DR,more preferably HLA-DR1, HLA-DR3, HLA-DR4 and / or HLA-DR11.

As used herein, MHC of class I indicates HLA of class I, preferablyHLA-A and /or HLA-B, more preferably HLA-A.

In detail HLA-A is chosen from the group consisting of HLA-A * 02: 01,HLA-A * 01: 01, HLA-A * 26: 01, HLA-A * 03: 01 and / or HLA-A * 24:02,preferably HLA-A * 02: 01 and / or HLA-A * 24: 02.

Furthermore, HLA-B is chosen in the group consisting of HLA-B * 40: 01,HLA-B * 15: 01, HLA-B * 27: 05, HLA-B * 07: 02, HLA-B * 58: 01, HLA-B *08: 01 and / or HLA-B * 39: 01, preferably HLA-B * 40: 01, HLA-B * 15:01 and / or HLA-B * 08: 01.

As used herein one or more peptides can be also comprised in sequencesincluding non-peptide bonds and / or in which one or more peptides arepart of a fusion protein, for example, comprising N-terminal amino acidsof the invariable chain associated with the HLA-DR antigen.

The peptide according to the present invention, or the peptide variantas defined above, may comprise additional portions of amino acids at theN-terminus or C-terminus, which are not necessarily part of the peptideportion that serves as an epitope for the MHC molecules.

However, these additional parts can be important to provide an efficientintroduction of the peptide according to the present invention into thecells. In one embodiment of the present invention, the peptide is partof a fusion protein comprising, for example, the 80 N-terminal aminoacids of the invariable chain associated with the HLA-DR antigen (p33)as derived from the NCBI database, GenBank_Accession number X00497.

In other embodiments of the peptides, the peptides of the presentinvention are bound to an antibody as described below, or a functionalpart of the antibody itself, in particular peptides can be inserted intoa sequence of an antibody, so as to be specifically carried by theantibody or, for example, can be fused to an antibody, or inserted intoan antibody, which is specific for dendritic cells.

Furthermore, the peptide or variant according to the present inventioncan be further modified or modified to improve the stability and / orthe binding with the MHC molecules, in order to obtain a stronger immuneresponse. Methods for optimizing a peptide sequence are well known inthe art and include, for example, the introduction of reverse peptidebonds or non-peptide bonds.

In a reverse peptide bond the amino acid residues are not joined bypeptide bonds (—CO—NH—), but the peptide bond is reversed. Suchretro-inverse peptidomimetic peptides can be made using methods known inthe art, such as those described in Meziere et al (1997) J. Immunol.159, 3230-3237, incorporated herein by reference. This approach involvesthe creation of pseudopeptides containing changes that involve theskeleton and not the orientation of the side chains. Meziere et al(1997) show that these pseudopeptides are useful for MHC binding andhelper T cell responses.

Retro-inverse peptides, which contain NH—CO bonds instead of CO—NHpeptide bonds, are much more resistant to proteolysis.

A non-peptide bond can be, for example, one of the following: —CH2—NH,—CH2S—, —CH2CH2—, —CH═CH—, —COCH2—, —CH (OH) CH2— and —CH2SO—. U.S. Pat.4,897,445 provides a method for the solid phase synthesis of non-peptidebonds (—CH2—NH) in polypeptide chains involving the use of polypeptidessynthesized by standard procedures and the non-peptide bond synthesizedby the reaction of an amino-aldehyde and an amino acid in the presenceof NaCNBH3.

The peptides comprising the sequences described above can be synthesizedwith further chemical groups present at their amino and/or carboxyl endgroups, to improve the stability, bioavailability and / or affinity ofthe peptides. For example, hydrophobic groups such as thecarbobenzyloxy, dansyl or t-butyloxycarbonyl groups can be added to theamino terminals of the peptides. Similarly, an acetyl group or a9-fluorenylmethoxycarbonyl group can be placed at the amino terminals ofthe peptides. Furthermore, the hydrophobic group, the t-butyloxycarbonylor an amide group can be added to the carboxy-terminus of the peptides.

Furthermore, the peptides according to the present invention can besynthesized in such a way as to alter their steric configuration. Forexample, the D isomer of one or more of the amino acid residues of thepeptide can be used, rather than the usual L isomer. Further, at leastone of the amino acid residues of the peptides of the invention can bereplaced by one of the well known amino acid residues, not present innature. Alterations such as these can serve to increase the stability,bioavailability and / or binding action of the peptides of theinvention.

Similarly, a peptide or a variant of the peptide according to thepresent invention can be chemically modified or modified by reactingspecific amino acids before or after the synthesis of the peptide.Examples for such modifications are well known in the art and aresummarized for example in R. Lundblad, Chemical Reagents for ProteinModification, 3rd ed. CRC Press, 2005, which is incorporated herein byreference.

Chemical modification of amino acids includes, but is not limited to:modification by acylation, amidation, pyridoxylation of lysine,reductive alkylation, trinitrobenzylation of amino groups with2,4,6-trinitrobenzenesulfonic acid (TNBS), amide modification ofcarboxylic groups and sulfhydryl modification by oxidation withperformic acid of cysteine to cysteic acid, formation of mercurialderivatives, formation of mixed disulfides with other thiol compounds,reaction with maleimide, carboxymethylation with iodoacetic acid oriodoacetamide and carbamylation with cyanate at alkaline pH. In thisregard, the methodologies for the chemical modification of proteins arewell known to one skilled in the art.

In short, the modification of arginyl residues in proteins is oftenbased on the reaction of vicinal dicarbonyl compounds such asphenylglyoxal, 2,3-butanedione and 1,2-cyclohexanedione to form anadduct. Another example is the reaction of methylglyoxal with arginineresidues. Cysteine can be modified without the concomitant modificationof other nucleophilic sites such as lysine and histidine.

Consequently, a large number of cysteine modification reagents areavailable. The websites of companies such as Sigma-Aldrich(http://www.sigma-aldrich.com) provide information on specific reagents.

The selective reduction of disulfide bonds in proteins is also wellknown. Disulfide bonds can be formed and oxidized during the heattreatment of biopharmaceutical products. Woodward’s K reagent can beused to modify specific glutamic acid residues. N- (3- (dimethylamino)propyl) -N′-ethylcarbodiimide can be used to form intra-molecularconnections between a lysine residue and a glutamic acid residue. Forexample, diethyl pyrocarbonate is a reagent for the modification ofhistidyl residues in proteins. Histidine can also be modified using4-hydroxy-2-nonenal. The reaction of lysine residues and other α-aminogroups is, for example, useful in the binding of peptides to surfaces orin the cross-linking of proteins / peptides. Lysine is the attachmentsite of poly (ethylene) glycol and the major modification site inprotein glycosylation. The methionine residues in proteins can bemodified for example with iodoacetamide, bromoethylamine and chloramineT.

Tetranitromethane and N-acetylimidazole can be used for the modificationof tyrosyl residues. Cross-linking through the formation of di-tyrosinecan be accomplished with hydrogen peroxide / copper ions.

N-bromosuccinimide, 2-hydroxy-5-nitrobenzyl bromide or3-bromo-3-methyl-2- (2-nitrophenylmercapto) -3H-indole (BPNS-skatole)have been used in some tryptophan modification studies.

Successful modification of therapeutic proteins and peptides with PEG isoften associated with a prolongation of the circulatory half-life, whilecross-linking of proteins with glutaraldehyde, polyethylene glycoldiacrylate and formaldehyde is used for the preparation of hydrogels.Chemical modification of allergens for immunotherapy is often achievedby carbamylation with potassium cyanate.

In general, peptides and variants (at least those containing peptidebonds between amino acid residues) can be synthesized by theFmoc-polyamide mode of solid phase peptide synthesis, as disclosed byLukas et al. (Synthesis of the solid phase peptide under continuous flowconditions Proc. Natl Acad Sci USA, May 1981; 78 (5): 2791-2795).Temporary protection of the N-amino group is provided by the9-fluorenylmethyloxycarbonyl (Fmoc) group.

In a further embodiment, the present invention relates to an antibodyconjugated with one or more peptides, and /or variants and/or salts andin which the antibody is capable of recognizing antigen presenting cells(APCs), preferably dendritic cells.

The antibody according to the present invention is able to recognizetype C lectin receptors such as DC-SIGN (CD209) on dendritic cells. Inthis way the share of peptide captured by the dendritic cells issignificantly increased and the peptide is presented more effectively toT cells.

In another embodiment, the present invention relates to a T lymphocytereceptor capable of binding one or more peptides as previously definedin which the receptor optionally comprises one or more co-stimulatorydomains. The receptor is, for example, a chimeric receptor for theantigen (CAR).

In another embodiment, the present invention relates to a nucleotidesequence (DNA or RNA) which codes for a peptide as described above orfor an antibody as described above.

In a further embodiment, the present invention relates to a nucleotidesequence that codes for T lymphocyte receptor capable of binding one ormore peptides as previously defined as previously defined.

In a further embodiment, the present invention relates to an expressionvector comprising a nucleotide sequence as previously defined.

It is specified that in the context of this discussion, the expressionpharmaceutical composition also refers indiscriminately to animmunogenic composition or to a vaccine composition.

Preferably, such immunogenic composition or vaccine compositioncomprises one or more peptides selected from the group comprising orconsisting of: MLAGNEFQV (SEQ ID NO. 108), TMLNILALV (SEQ ID NO. 109),YYYQRALEI (SEQ ID NO. 110), KITEYLERV (SEQ ID NO. 111), VYSACSFTF (SEQID NO. 112), TLLKVTLEV (SEQ ID NO. 113), LYSGTAADF (SEQ ID NO. 114),MVMSFVNLV (SEQ ID NO. 115), FYFRNHFCI (SEQ ID NO. 116), LLNQQICPV (SEQID NO. 117), VYVAFSEFF (SEQ ID NO. 118), MLAGNAFTA (SEQ ID NO. 119),ALMAFTSAV (SEQ ID NO. 120), DYFRNQFKI (SEQ ID NO. 121). Preferably theimmunogenic composition or vaccine composition comprises one or morepeptides selected from the group comprising or consisting of MLAGNAFTA(SEQ ID NO. 119), ALMAFTSAV (SEQ ID NO. 120), DYFRNQFKI (SEQ ID NO.121). Still in a further preferred embodiment, the immunogeniccomposition or vaccine composition further comprises one or morepeptides selected from the group comprising or consisting of FINSGAWQI(SEQ ID NO.17), KLTTWILPK (SEQ ID NO.43), KTKIFQFLK (SEQ ID NO. 50),PYMLVVGNI (SEQ ID NO. 65), SMDDQLNQL (SEQ ID NO. 83), WQIGLANFV (SEQ IDNO. 96).

This pharmaceutical composition can be advantageously used beforeadministering an epigenetic drug. The pharmaceutical composition has thefunction of activating the immune response, while the epigenetic drughas the function of making the tumor cells express the HERV proteins,and therefore the epitopes. Such epitopes will then be recognized by theimmune system previously activated by the pharmaceutical compositionaccording to the present invention.

Further, in another embodiment, the present invention relates to apharmaceutical composition comprising or consisting of one or more ofthe following active ingredients:

-   a receptor according to the present invention;-   a nucleotide sequence in accordance with the present invention;-   a vector in accordance with the present invention or a cell    comprising a vector comprising the nucleotide sequence in accordance    with the present invention, and optionally one or more immune    checkpoint inhibitor drugs, together with one or more    pharmaceutically acceptable excipients and / or adjuvants .

This composition can be advantageously administered after administeringan epigenetic drug. As mentioned above, the epigenetic drug has thefunction of making the tumor cells express the HERV proteins, andtherefore the epitopes. These epitopes will therefore be recognized bythe active ingredients of the pharmaceutical composition according tothe present invention just mentioned.

Similarly, ie after the administration of an epigenetic drug, apharmaceutical composition according to the present invention can beadministered.

In accordance with a further embodiment, the present invention relatesto a pharmaceutical composition comprising or consisting of T cells inaccordance with the present invention, and optionally one or more immunecheckpoint inhibitor drugs, together with one or more excipients and /or pharmaceutically acceptable adjuvants.

Again, the present invention relates to one or more peptides accordingto the present invention, an antibody according to the presentinvention, a receptor according to the present invention, a nucleotidesequence according to the present invention, a vector according to thepresent invention, a cell according to the present invention, a T cellaccording to the present invention, a pharmaceutical compositionaccording to the present invention, for use as a medicament.

In a further embodiment, the present invention relates to:

-   one or more peptides according to the present invention;-   an antibody according to the present invention;-   a receptor according to the present invention;-   a nucleotide sequence in accordance with the present invention;-   a vector according to the present invention;-   a cell according to the present invention;-   a T cell according to the present invention;-   a pharmaceutical composition in accordance with the present    invention;

for use in the treatment of cancers, such as hepatocellular cancer,breast cancer, melanoma, colon cancer, pancreatic cancer, kidney cancer,prostate cancer, lung cancer in which:

-   one or more peptides according to the present invention;-   the antibody in accordance with the present invention;-   the nucleotide sequence according to the present invention;-   the vector according to the present invention which comprises the    nucleotide sequence according to the present invention;-   the cell comprising the peptide or vector comprising the nucleotide    sequence according to the present invention or the pharmaceutical    composition according to the present invention;

they are administered before an epigenetic drug capable of inducing theexpression of HERV (Human endogenous retroviruses) sequences in tumorcells; while the receptor in accordance with the present invention, theT cell in accordance with the present invention, the nucleotide sequencein accordance with the present invention, the vector comprising thenucleotide sequence in accordance with the present invention, the cellcomprising the receptor either carrier according to the presentinvention or the pharmaceutical composition according to the presentinvention; it is administered after an epigenetic drug capable ofinducing the expression of HERV sequences in tumor cells, in which saidepigenetic drug is preferably a DNA methyltransferase inhibitor.

Finally, the present invention relates to a combination comprising orconsisting of one or more peptides according to the present invention,an antibody according to the present invention, a receptor according tothe present invention, a nucleotide sequence according to the presentinvention, a vector according to the present invention, a cell accordingto the present invention, a T cell according to the present inventionand / or a pharmaceutical composition according to the presentinvention, with an epigenetic drug capable of inducing the “ expressionof HERV sequences in cancer cells, for sequential use in the treatmentof tumors, such as hepatocellular carcinoma, breast cancer, melanoma,colon cancer, pancreatic cancer, kidney cancer, prostate cancer, lungcancer, in which the epigenetic drug is preferably a DNAmethyltransferase inhibitor. Preferably, for sequential use in thetreatment of hepatocellular carcinoma, breast cancer, melanoma, coloncancer, pancreatic cancer, kidney cancer, prostate cancer, lung cancer.

It is specified that in the context of this discussion the expression“sequential use” means the subsequent administration of the elements ofthe combination, that is, the peptides, the antibody, the receptor, thenucleotide sequence, the vector, the cell, the cell T, of the epigeneticdrug, in distinct and possibly different pharmaceutical forms.

The present invention is described by way of illustration, but not oflimitation, according to its preferred embodiments, but it is to beunderstood that variations and / or modifications may be made by thoseskilled in the art without thereby departing from the relative scope ofprotection, as defined from the attached claims.

DETAILED AND EXEMPLIFICATIVE DESCRIPTION OF THE INVENTION

The present invention will be described, for illustrative but notlimitative purposes, according to its preferred embodiments, withparticular reference to the figures of the attached drawings, in which:

FIG. 1 . Binding Assay to HLA-A * 02: 01. HERV peptides predicted tobind to the indicated HLAs were reacted with T2 cells, positive forHLA * 02: 01, in which the pathway for intracellular antigenpresentation is not functional. The HLA is, therefore, able to bind onlyepitopes provided from outside. The results show that only the predictedHERV epitopes specific for HLA * 02: 01 bind to the HLA expressed by T2cells, which is detectable by specific antibodies. Neg: negativecontrol, indicates solvent without any added peptide; Pos: positivecontrol, the known HLA*0201 peptide binder KLQAGTVFV (SEQ ID NO. 141)was used. Asterisks are by general convention an indication ofstatistical significance (the smaller the Pvalue, the greater thesignificance and the greater the number of asterisks).

FIG. 2 . Stability Assay at HLA-A * 02: 01. The stability of the bindingof the predicted HERV peptides to the HLA * 02: 01 of T2 cells wasverified by evaluating the expression levels of HLA on the cell surfaceover time. For all the HERV peptides predicted to bind HLA * 02: 01there is a half-life of about 6 hours. Positive and negative controlsare the same as in FIG. 1 .

FIG. 3 . IFNγ ELISpot Assay with cells from HCC HLA-A * 02: 01 patients.PBMCs from HCC patients positive for HLA-A * 02: 01 and for HLA-A * 24:02 were purified and reacted with peptides predicted to be specific forthe two alleles. The result of the IFNγ ELISpot assay shows thatpatients with HCC have a proportion of circulating T lymphocytes capableof recognizing only the HERVs peptides predicted for HLA * 02: 01 andfor HLA-A * 24: 02.

FIG. 4 . Identification of HCC-related proteins. Number of HCC samplesin the protein Atlas positive at Immunohistochemistry (IHC) for specificproteins.

FIG. 5 . Survival analysis. Correlation between gene expression and5-year survival in HCC patients. (A) average of 5-year survival inpatients with high or low protein expression of all nine proteins; (B)5-year survival in patients with or low expression of each individualprotein; (C) Kaplain-Meier survival curve in patients with or lowexpression of each individual protein.

FIG. 6 . Gene expression analysis. Expression levels of each gene incancer (HCC) and paired non-tumoral liver tissues.

FIG. 7 . Peptide prediction. Number of predicted epitopes per eachprotein with affinity values <10 nM, 10< affinity <50 nM, >50 nM.

FIG. 8 . Epitope modeling and molecular docking. The conformation of thepaired viral and TAA peptides bound to the HLA-A*02:01 molecule isshown. Dark-grey areas = contact points with HLA molecule, TCR α chainand TCR β chain.

MATERIALS AND METHODS Collection of Tissue Samples and Patients

14 chronic HCC patients infected with HCV undergoing liver resectionwere enrolled at the National Cancer Institute “Pascale” followingreading and signing of the informed consent. A liver biopsy of the tumorand adjacent non-tumor liver tissue was obtained from each patient withhistologically confirmed HCC at the time of surgery and stored at -80°C. until use in RNA stabilizing agent (RNAlater, Qiagen) for RNAsequencing. Fresh human peripheral blood mononuclear cells (PBMCs) wereisolated by centrifugation of the Ficoll-Hypaque density gradient andcultured in appropriate medium consisting of RPMI 1640 (CapricornScientific GmbH) containing 2 mM L-Glutamine, supplemented with 10%serum heat inactivated human (Capricorn Scientific GmbH), 25 mM HEPESbuffer solution (Capricorn Scientific GmbH), 50 IU / ml penicillin and50 µg / ml streptomycin (Gibco Life Technologies), 20 µg / ml gentamicin(Capricorn Scientific GmbH). The PBMCs were kept in liquid nitrogen in10% DMSO until the moment of use.

RNA Extraction, Library Preparation and Sequencing

Liver samples were homogenized in the TRIzol reagent using the TissueLyser Disruption System (Qiagen), immediately frozen on dry ice, and thetotal RNA was purified according to the manufacturer’s protocol(Invitrogen). RNA samples were quantified by NanoDrop1000spectrophotometer (Thermo Fisher Scientific) and showed a 260/280absorbance ratio of approximately 1.8-2. RNA quality was assessed bydigital electrophoresis on the Experion System using RNA StdSens Kit andRNA chip (Bio-Rad). The cDNA library sequencing preparation wasperformed on 4 µg of total RNA per sample using the TruSeq RNA strandedsample preparation kit (Illumina). The cDNA libraries were quantified byQubit Fluorometer (Q32866; LifeTechnologies) and Qubit dsDNA High SensayKit. The overall quality of the libraries was assessed on the ExperionSystem by DNA 1 K Analysis Kit and DNA chips (Bio-Rad). The pairedlibraries (100 × 2 bp) were sequenced at high coverage on IlluminaHiSeq2000 NGS.

RNA-Seq Data Analysis

Quality control was performed on the total number of raw readings usingthe FastQC tool(http://www.bioinformatics.babraham.ac.uk/projects/fastqc/). The highquality reads were mapped to the human reference transcriptome and humanreference genome using TopHat2 v2.0.10 [30]. Only uniquely mapped readswere used to quantify gene expression in each sample and to calculatethe differential expression between non-tumor and tumor samples [31].The identification of the HERV sequences in the samples was carried outon the basis of the sequences deposited in the databasehttps://herv.img.cas.cz/. The sequences that were selected forsubsequent antigenic epitope prediction analyzes were those that showeda ≥2 ratio of tumor to adjacent non-tumor tissue.

Selection of the Protein Sequences of the HERVs Genes

The sequences identified and selected in the databasehttps://herv.img.cas.cz/ were translated using the tool ExPASyhttps://web.expasy.org/translate/ and aligned with Blasthttps://blast.ncbi.nlm.nih.gov/Blast.cgi to verify the specific identityof the HERV proteins.

Analysis of the Prediction of HERVs Epitopes

Epitope prediction was performed on HERV protein sequences usingprediction tools available at http://www.cbs.dtu.dk/services/. NetMHCpanversion 4.0 http://www.cbs.dtu.dk/services/NetMHCpan/ was used topredict epitopes restricted to MHC class I alleles HLA-A01: 01, HLA-A02:01, HLA-A03: 01, HLA-A24: 02, HLA-A26: 01, HLA-B07: 02, HLA-B08: 01,HLA-B27: 05, HLA-B39: 01, HLA-B40: 01, HLA-B58: 01, HLA-B15: 01. Theentire HERV-K pol sequence was used to predict antigens with a length of9 amino acids by scanning the overlapping peptides of the entire proteinsequence. Antigens were selected for each class I HLA if with predictedaffinity <100 nM.

Homology Analysis of HERVs Epitopes

The Immune Epitope Database (IEDB; http://www.iedb.org/) was used forsequence homology analysis of predicted HERV epitopes with knownhuman-derived antigens and experimentally validated pathogens. Thehomology analysis focused on the amino acid residues in the bindingpositions of the peptides to the Tcell receptor (positions 1, 4, 5 and8).

In Silico Analysis for HCC From the “Human Protein Atlas”

Starting from Downloadable data section(https://www.proteinatlas.org/about/download) of Human Protein Atlasdatabase, Normal Tissue and Pathology dataset were downloaded. Normaltissue and Pathology dataset contain expression profiles of proteins ofdifferent human tissues samples, non tumoral and tumoral respectively,evaluated by immunohistochemistry on tissue micro array. Normal Tissuedataset is an extremely wide list containing information about theexpression of several proteins into different cell types of a specifichuman non tumoral tissue. To identify tumor specific proteins, onlythose proteins who were defined as “NOT DETECTED” in hepatocytes andbile duct cells were selected. As consequential step, Pathology datasetwas analyzed to verify if proteins that were defined as “NOT DETECTED”into Normal Tissue dataset could have been detected into tumoral tissuesamples, in particular were selected all proteins that resulted to beabsent in normal cell types but were detected into “LIVER CANCER” tissuesamples at “HIGH”, “MEDIUM” or “LOW” expression level. All proteinsdefined as “NOT DETECTED” into liver tumor samples were excluded fromthe analysis; all other proteins were then divided into differentgroups, corresponding to number of samples with a high level ofstaining.

Overall Survival Analysis in HCC

Survival analysis were obtained from The Human protein Atlas, sectionPathology Atlas (https://www.proteinatlas.org/humanproteome/pathology)selecting liver cancer into “RNA EXPRESSION OVERVIEW” panel. Onlyproteins with p<0.05, whose high expression was correlated with poorsurvival rate, were selected for subsequent analysis.

HLA Class I Epitope Prediction for Overexpressed Proteins in HCC andComparison to Viral Antigens

In order to assess if overexpressed proteins (ISG15, KLC1, SEMA3A, BMP6,DYRK4 or PLTP) could lead to potential epitopes, FASTA format of proteinsequences were downloaded from UniProt database(https://www.uniprot.org/) to perform an analysis of binding capabilitywith NetMHCpan4.1a (http://www.cbs.dtu.dk/services/NetMHCpan/). Thisserver predicts binding of peptides derived from an antigenic sequenceto an MHC molecule; for this analysis, we focused our attention onHLA-A*02:01, the most common allele, and 9-mer peptides, selecting weakand strong binding peptides (WB; SB). To evaluate any potential homologyof these predicted epitopes with molecules derived from pathogens,9-mers were analyzed using Nucleotide BLAST(https://blast.ncbi.nlm.nih.govBlast.cgi?PROGRAM=blastn&PAGE_TYPE=BlastSearch&LINK_LOC=blasthome) and the Immune Epitope Database (IEDB)(https://www.iedb.org/). Sequences with high similarity to the predictedepitopes were then aligned and processed with NetMHCpan4.1a to evaluatetheir binding affinity. (http://www.cbs.dtu.dk/services/NetMHCpan/).

The 3D Structure of Epitopes for HLA Class I

The 3D structure of interaction between of HLA-HLA-A*02:01 with selectedpeptides was predicted using Pymol (https://pvmol.org/2/) and MolsoftICM (http://www.molsoft.com/) software. The PDB format of complexbetween HLA-A*02:01 (1AO7), a viral peptide (TAX) and human T-cellreceptor was downloaded from RCS Protein Data Bank (PDB) website(https://www.rcsb.org/). Viral peptide sequence was replaced withpredicted epitopes using Pymol visualization system and Molsoft ICMsoftware was used to visualize the molecular docking of HLA-A*02:01 withselected 9-mers.

Peptide Synthesis

The peptides were synthesized with a purity> 95%. The lyophilized powderwas dissolved in dimethyl sulfoxide (DMSO; Sigma-Aldrich), diluted inphosphate buffered saline (PBS 1X, Gibco Life Technologies) and storedat -80° C. until use.

T2 Cell Line Deficient in TAP

The human TAP-deficient T2 cell line (174xCEM.T2; ATCC CRL 1992™) wasacquired from the American Type Culture Collection (ATCC;https://www.atcc.org/). Cell line T2 was maintained in Iscove’s modifiedDulbecco medium (IMDM; Gibco Life Technologies) containing 25 mM HEPESand 2 mM L-Glutamine, supplemented with 20% fetal bovine serum (FBS,Capricorn Scientific GmbH), 100 IU / ml of penicillin and 100 µg / ml ofstreptomycin (Gibco Life Technologies). The cells were kept at 37° C. ina humidified incubator with 5% CO2.

Affinity Assays for Peptide Bond and BFA Decay

The affinity tests for the binding of the peptides to HLA-A * 02: 01 andthe Brefeldin A decay test (BFA) were performed for each synthesizedpeptide. Briefly, T2 cells were seeded at a concentration of 3.5 × 10⁵cells per well in 24-well plates and incubated overnight in a humidifiedincubator at 37° C. with 5% CO2 with the peptides (concentrations : 10µM, 20 µM, 50 µM, 100 µM) in serum-free IMDM medium containing 3 µg / mlof β2 (Sigma -Aldrich) microglobulin. After incubation, the cells wereharvested and centrifuged at 200 × g for 5 minutes. Subsequently, thecells were washed twice with phosphate buffered saline (PBS 1X, GibcoLife Technologies) and stained with R-PE conjugated anti-HLA A2monoclonal antibodies (Cat. 343306; BioLegend), for 30 minutes at 4° C.and analyzed with the Attune™ NxT flow cytometer (Thermo FisherScientific). The OVA peptide was used as a negative control and T2 cellswith no added peptide were used as a background control. Thefluorescence index (FI) was calculated using the following formula: FI =[average fluorescence intensity (MFI) sample - MFI background] / MFIbackground, where the MFI background represents the value withoutpeptide. An FI> 0.5 was set as a threshold to indicate peptides withaffinity for the HLA molecule A * 02: 01. For the Brefeldin A decaytest, T2 cells were seeded at a concentration of 5 × 10⁵ cells to wellinto 24-well plates and cultured overnight as described above withcandidate peptides or control peptide (CAP 1 was used as control) at afinal concentration of 50 µM. After incubation, the cells were washedand incubated with 1X BFA (brefeldin A solution, 420601, BioLegend) inserum-free IMDM medium, for 1 hour at 37° C. Cells were collected everytwo hours (T0, T2, T4, T6, T8), washed with phosphate buffered saline(PBS 1X, Gibco Life Technologies), stained with anti-HLA A * 02: 01fluorescent monoclonal antibodies (Cat. 343306 ; BioLegend) and analyzedby flow cytometry. The stability of each HLA A2-bound peptide wasmeasured as the DC₅₀ value, which was defined as an estimate of the timerequired for a 50% reduction in the MFI value recorded at time 0. TheDC₅₀ value was calculated according to the formula : MFI at indicatedtime points / MFI at time 0 × 100. All experiments were performed intriplicate.

IFN γ ELISpot

The IFNy ELISpot assay (BDTM human IFNγ ELISPOT Set) was performed withPBMCs from HCC patients, stimulating 4 × 10⁶ PBMC / ml / well withpeptides at the final concentration of 10 µg / ml. On the third day, 10U/ ml of IL 2 was added to each well. On the fifth day, half the volumeof medium was replaced with fresh medium containing IL 2 at a finalconcentration of 10U / ml. On the seventh day, the PBMCs were againstimulated with each peptide. On day 10, cells were harvested for theELISpot IFNγ assay. Each peptide was added to a final concentration of10 µg / mL at 2 × 10⁵ PBMC per well in 100 µl of RPMI 1640 (CapricornScientific GmbH). The PBMCs were grown at 37° C. in a humidifiedincubator with 5% CO2 for 20 hours. Stimulation with 10 µg / ml PHA(PHA-K; Capricorn Scientific GmbH) was used as a positive control, PBMCswithout peptide addition were used as negative control, RPMI 1640 medium(Capricorn Scientific GmbH) was used as basic control. The wells wereread with an ELISpot Reader AID system (AID GmbH, Strassberg, Germany)and the mean was obtained from readings of the wells in triplicate. Datawere analyzed by subtracting the mean number of spots in the wells withuntreated cells. Spot formation units (SFUs) were calculated as thefrequency for 1×10⁶ PBMC.

Statistic Analysis

Comparison of the individual data points was performed with the unpairedtwo-sided Student’s t-test and ANOVA, as appropriate. All P-values weretwo-sided and considered significant if less than 0.05.

RESULTS Example 1. Bioinformatic Analysis of the Expression of HERVGenes in Samples Of Patients With Hepatocellular Carcinoma (HCC) andIdentification of Epitopes Associated With Different Classes of HLAClass I Identification of Over-Expressed ERV Sequences in HCC

The expression analysis of the HERV sequences in tumor samples (T)versus the non-tumor counterpart (NT) showed the over-expression in eachanalyzed sample of HERV sequences identified in the Human EndogenousRetrovirus Database (HERVd) https://herv.img.cas.cz / with a T / NTratio ≥ 2. Such sequences include both LTR (L) and internal (I) regions.The HERV sequences identified in the HERVd database with a T / NT ratiogreater than or equal to 2 (at least 2-fold expression in tumor tissuecompared to non-tumor tissue) are shown below in Table 1. In particular,in the ID column there are references alphanumeric which, if entered inthe HERVd database (in the “Entities” section, in the “Name equals”field) allow to obtain information and details of the sequences, as wellas the sequences themselves.

TABLE 1 SAMPLE CHROM START STOP ID NAME Sub type NT T ratio T vs. NTHLA072 1 349009 349814 ERV_0000262 MER31-int I 0.18 2.37 13.18 HLA063 11382090 1386135 ERV_0001122 MER66-int,MER66C LI 2.37 4.83 2.03 HLA078 11382090 1386135 ERV_0001122 MER66-int,MER66C LI 0.88 3.15 3.57 HLA072 12637771 2638501 ERV_0002190 ERVL-E-int I 0.34 2.75 8.09 HLA078 1 42577124259619 ERV_0003162 THE1C,THE1C-int LI 0.00 1.61 300.00 HLA078 1 79606257960739 ERV_0006438 MER84-int I 0.00 3.17 300.00 HLA076 1 1331359213313729 ERV_0012312 MER34-int I 0.46 1.66 3.62 HLA061 1 1660569416605874 ERV_0015940 MLT1F-int I 5.14 12.38 2.41 HLA069 1 1660569416605874 ERV_0015940 MLT1F-int I 2.22 14.20 6.41 HLA073 1 1660569416605874 ERV_0015940 MLT1F-int I 0.43 11.62 27.17 HLA076 1 1660569416605874 ERV_0015940 MLT1F-int I 3.65 9.74 2.67 HLA078 1 1660569416605874 ERV_0015940 MLT1F-int I 9.07 41.71 4.60 HLA053 1 1690366816904443 ERV_0016202 LTR23-int,LTR56 LI 0.08 2.02 24.47 HLA063 120154110 20160513 ERV_0020143 HERVE-int,LTR2C LIL 3.68 8.06 2.19 HLA0731 20154110 20160513 ERV_0020143 HERVE-int,LTR2C LIL 0.12 6.32 53.08HLA076 1 20154110 20160513 ERV_0020143 HERVE-int,LTR2C LIL 1.11 2.872.58 HLA078 1 20154110 20160513 ERV_0020143 HERVE-int,LTR2C LIL 0.5315.20 28.46 HLA082 1 20154110 20160513 ERV_0020143 HERVE-int,LTR2C LIL1.03 2.45 2.39 HLA063 1 20160106 20160228 ERV_0020144 Harlequin-int I3.68 8.06 2.19 HLA073 1 20160106 20160228 ERV_0020144 Harlequin-int I0.12 6.32 53.08 HLA076 1 20160106 20160228 ERV_0020144 Harlequin-int I1.11 2.87 2.58 HLA078 1 20160106 20160228 ERV_0020144 Harlequin-int I0.53 15.20 28.46 HLA082 1 20160106 20160228 ERV_0020144 Harlequin-int I1.03 2.45 2.39 HLA078 1 21453079 21453988 ERV_0021799 ERVL-E-int,LTR33LI 0.34 2.33 6.90 HLA078 1 31458573 31466684 ERV_0034498 HERVIP10F-int I0.07 33.86 470.34 HLA053 1 31517845 31518912 ERV_0034558HERVL-int,MLT2A1 LI 0.15 2.08 13.87 HLA058 1 31517845 31518912ERV_0034558 HERVL-int,MLT2A1 LI 0.00 1.54 300.00 HLA078 1 3151784531518912 ERV_0034558 HERVL-int,MLT2A1 LI 0.26 1.96 7.57 HLA058 133325217 33327957 ERV_0036879 MLT1F,MLT1F-int LIL 2.63 5.45 2.07 HLA0781 33325217 33327957 ERV_0036879 MLT1F,MLT1F-int LIL 4.74 11.58 2.44HLA058 1 33325576 33325665 ERV_0036880 MLT1F-int I 2.63 5.45 2.07 HLA0781 33325576 33325665 ERV_0036880 MLT1F-int I 4.74 11.58 2.44 HLA067 135982765 35982904 ERV_0039746 MLT1J-int I 4.27 8.98 2.10 HLA078 135982765 35982904 ERV_0039746 MLT1J-int I 0.68 10.47 15.32 HLA065 138959345 38962221 ERV_0043236 MLT1D,MLT1D-int LI 0.00 10.68 300.00HLA078 1 38959345 38962221 ERV_0043236 MLT1D,MLT1D-int LI 0.00 2.72300.00 HLA053 1 39543019 39543161 ERV_0043877 ERV3-16A3_I-int I 0.001.73 300.00 HLA078 1 41436846 41441007 ERV_0045987 ERVL-E-int I 0.101.54 15.05 HLA058 1 44206493 44206571 ERV_0048686 ERVL-E-int I 0.00 2.00300.00 HLA058 1 45189915 45191639 ERV_0049750 ERV3-16A3_I-int,LTR16 LI1.09 10.99 10.09 HLA061 1 45189915 45191639 ERV_0049750ERV3-16A3_I-int,LTR16 LI 0.36 7.30 20.03 HLA072 1 45189915 45191639ERV_0049750 ERV3-16A3_I-int,LTR16 LI 0.10 4.26 43.93 HLA078 1 4518991545191639 ERV_0049750 ERV3-16A3_I-int,LTR16 LI 0.00 2.99 300.00 HLA082 146056993 46059302 ERV_0050693 THE1A,THE1A-int LIL 0.13 1.55 11.86 HLA0671 47541526 47543804 ERV_0052168 THE1B,THE1B-int LIL 0.59 3.15 5.36HLA082 1 47541526 47543804 ERV_0052168 THE1B,THE1B-int LIL 0.13 28.31220.09 HLA058 1 53204634 53207286 ERV_0058440 THE1D,THE1D-int LIL 0.892.96 3.34 HLA065 1 53204634 53207286 ERV_0058440 THE1D,THE1D-int LIL0.46 2.03 4.45 HLA067 1 53204634 53207286 ERV_0058440 THE1D,THE1D-intLIL 1.19 5.82 4.91 HLA072 1 53204634 53207286 ERV_0058440THE1D,THE1D-int LIL 0.46 1.53 3.29 HLA053 1 53892592 53892626ERV_0059244 ERVL-E-int I 0.00 2.76 300.00 HLA066 1 53892592 53892626ERV_0059244 ERVL-E-int I 0.00 2.00 300.00 HLA058 1 54101969 54105569ERV_0059490 ERV3-16A3_I-int,LTR16A LI 1.89 4.29 2.27 HLA061 1 5410196954105569 ERV_0059490 ERV3-16A3_I-int,LTR16A LI 2.55 6.09 2.39 HLA063 154101969 54105569 ERV_0059490 ERV3-16A3_I-int,LTR16A LI 2.00 5.82 2.91HLA065 1 54101969 54105569 ERV_0059490 ERV3-16A3_I-int,LTR16A LI 1.204.46 3.70 HLA069 1 54101969 54105569 ERV_0059490 ERV3-16A3_I-int,LTR16ALI 1.55 4.39 2.82 HLA073 1 54101969 54105569 ERV_0059490ERV3-16A3_I-int,LTR16A LI 0.75 3.78 5.04 HLA078 1 54101969 54105569ERV_0059490 ERV3-16A3_I-int,LTR16A LI 1.66 8.01 4.81 HLA067 1 5503095355033231 ERV_0060553 THE1A,THE1A-int LIL 0.98 3.05 3.12 HLA071 155030953 55033231 ERV_0060553 THE1A,THE1A-int LIL 0.17 1.67 9.82 HLA0821 55030953 55033231 ERV_0060553 THE1A,THE1A-int LIL 0.77 3.19 4.15HLA053 1 56492595 56494136 ERV_0061992 MLT1D,MLT1D-int LI 17.65 51.562.92 HLA078 1 58629676 58633792 ERV_0064431 MSTD,MSTD-int LIL 0.70 1.962.81 HLA082 1 58629676 58633792 ERV_0064431 MSTD,MSTD-int LIL 0.76 1.562.05 HLA063 1 59514549 59515871 ERV_0065445 THE1A,THE1A-int LIL 1.323.63 2.74 HLA066 1 59514549 59515871 ERV_0065445 THE1A,THE1A-int LIL10.45 27.88 2.67 HLA067 1 59514549 59515871 ERV_0065445 THE1A,THE1A-intLIL 19.43 87.73 4.51 HLA069 1 59514549 59515871 ERV_0065445THE1A,THE1A-int LIL 3.52 34.16 9.71 HLA073 1 59514549 59515871ERV_0065445 THE1A,THE1A-int LIL 3.05 6.56 2.15 HLA076 1 5951454959515871 ERV_0065445 THE1A,THE1A-int LIL 1.57 6.27 4.00 HLA082 159514549 59515871 ERV_0065445 THE1A,THE1A-int LIL 5.99 21.78 3.63 HLA0631 59515081 59515522 ERV_0065446 THE1A-int I 1.32 3.63 2.74 HLA066 159515081 59515522 ERV_0065446 THE1A-int I 10.45 27.88 2.67 HLA067 159515081 59515522 ERV_0065446 THE1A-int I 19.43 87.73 4.51 HLA069 159515081 59515522 ERV_0065446 THE1A-int I 3.52 34.16 9.71 HLA073 159515081 59515522 ERV_0065446 THE1A-int I 3.05 6.56 2.15 HLA076 159515081 59515522 ERV_0065446 THE1A-int I 1.57 6.27 4.00 HLA082 159515081 59515522 ERV_0065446 THE1A-int I 5.99 21.78 3.63 HLA078 164186607 64192762 ERV_0070158 HERVL18-int,LTR18A LIL 0.00 2.80 300.00HLA072 1 67207422 67209695 ERV_0072969 THE1A,THE1A-int LIL 0.74 4.956.66 HLA078 1 67207422 67209695 ERV_0072969 THE1A,THE1A-int LIL 0.003.03 300.00 HLA053 1 67515309 67515734 ERV_0073337 LTR49-int I 0.24 2.5910.77 HLA073 1 67515309 67515734 ERV_0073337 LTR49-int I 0.19 1.99 10.59HLA078 1 67515309 67515734 ERV_0073337 LTR49-int I 0.58 1.82 3.16 HLA0781 68086244 68086394 ERV_0073918 MLT1J1-int I 0.00 1.73 300.00 HLA065 170281241 70282782 ERV_0075697 MLT1J,MLT1J-int LI 2.45 6.23 2.54 HLA072 170281241 70282782 ERV_0075697 MLT1J,MLT1J-int LI 1.33 7.45 5.58 HLA073 170367629 70374024 ERV_0075815 HERVH-int,LTR7 LIL 1.38 3.09 2.25 HLA078 170367629 70374024 ERV_0075815 HERVH-int,LTR7 LIL 0.83 3.95 4.77 HLA073 170372371 70373591 ERV_0075816 HERVH-int I 1.38 3.09 2.25 HLA078 170372371 70373591 ERV_0075816 HERVH-int I 0.83 3.95 4.77 HLA053 177706472 77708145 ERV_0081829 ERVL-E-int I 2.07 8.45 4.08 HLA058 177706472 77708145 ERV_0081829 ERVL-E-int I 0.16 2.34 14.57 HLA067 177706472 77708145 ERV_0081829 ERVL-E-int I 1.43 3.82 2.68 HLA053 178293370 78295657 ERV_0082398 THE1A,THE1A-int LIL 1.20 3.67 3.05 HLA0581 78293370 78295657 ERV_0082398 THE1A,THE1A-int LIL 2.81 6.42 2.28HLA058 1 78646295 78646353 ERV_0082651 MamGyp-int I 0.00 1.79 300.00HLA066 1 78646295 78646353 ERV_0082651 MamGyp-int I 0.00 1.78 300.00HLA067 1 78646295 78646353 ERV_0082651 MamGyp-int I 0.00 2.52 300.00HLA072 1 78646295 78646353 ERV_0082651 MamGyp-int I 0.00 5.34 300.00HLA082 1 78646295 78646353 ERV_0082651 MamGyp-int I 0.86 2.95 3.42HLA065 1 83669802 83670488 ERV_0086738 THE1B,THE1B-int LI 0.00 3.78300.00 HLA067 1 83669802 83670488 ERV_0086738 THE1B,THE1B-int LI 0.212.96 14.01 HLA058 1 84102016 84103764 ERV_0087089 MLT1G,MLT1G-int LI1.37 4.10 2.98 HLA061 1 84102016 84103764 ERV_0087089 MLT1G,MLT1G-int LI0.87 3.26 3.73 HLA072 1 84102016 84103764 ERV_0087089 MLT1G,MLT1G-int LI0.34 2.01 5.91 HLA053 1 84536109 84539258 ERV_0087444 ERVL-E-int I 0.853.42 4.03 HLA053 1 85398062 85399467 ERV_0088338 MER65-int I 0.39 2.065.30 HLA072 1 85398062 85399467 ERV_0088338 MER65-int I 0.54 2.62 4.85HLA058 1 87808368 87808808 ERV_0090418 LTR52,LTR52-int LI 0.00 9.94300.00 HLA067 1 87808368 87808808 ERV_0090418 LTR52,LTR52-int LI 0.001.93 300.00 HLA069 1 87808368 87808808 ERV_0090418 LTR52,LTR52-int LI0.33 2.55 7.68 HLA071 1 87808368 87808808 ERV_0090418 LTR52,LTR52-int LI0.71 3.66 5.18 HLA073 1 87808368 87808808 ERV_0090418 LTR52,LTR52-int LI0.00 1.78 300.00 HLA078 1 87808368 87808808 ERV_0090418 LTR52,LTR52-intLI 0.26 1.57 6.00 HLA053 1 88924529 88931881 ERV_0091394HERV17-int,LTR17 LIL 0.64 2.16 3.39 HLA053 1 89099124 89101806ERV_0091544 MER89-int I 0.49 1.58 3.24 HLA067 1 89099124 89101806ERV_0091544 MER89-int I 0.66 1.68 2.53 HLA066 1 89179228 89179558ERV_0091594 HERV4_I-int I 0.00 1.75 300.00 HLA063 1 89203974 89206780ERV_0091617 MSTA,MSTA-int LIL 1.16 4.00 3.45 HLA065 1 89203974 89206780ERV_0091617 MSTA,MSTA-int LIL 0.70 1.87 2.68 HLA067 1 89203974 89206780ERV_0091617 MSTA,MSTA-int LIL 0.74 2.03 2.74 HLA071 1 89203974 89206780ERV_0091617 MSTA,MSTA-int LIL 0.84 1.70 2.03 HLA073 1 89203974 89206780ERV_0091617 MSTA,MSTA-int LIL 0.69 1.56 2.27 HLA058 1 89386836 89387381ERV_0091736 HERV16-int I 0.54 1.81 3.33 HLA063 1 89386836 89387381ERV_0091736 HERV16-int I 0.00 4.20 300.00 HLA065 1 89386836 89387381ERV_0091736 HERV16-int I 0.00 2.35 300.00 HLA053 1 94252279 94252466ERV_0096209 HERVL-int I 0.00 1.98 300.00 HLA067 1 94428539 94430735ERV_0096364 THE1B,THE1B-int LIL 0.15 2.28 14.96 HLA058 1 9444482094450789 ERV_0096376 HERVK9-int,MER9a3 LIL 0.61 2.92 4.81 HLA065 194444820 94450789 ERV_0096376 HERVK9-int,MER9a3 LIL 0.40 1.67 4.23HLA067 1 94444820 94450789 ERV_0096376 HERVK9-int,MER9a3 LIL 2.21 8.964.05 HLA076 1 96140122 96153437 ERV_0097749 HERV9N-int,LTR12,LTR12_ LIL0.00 1.62 300.00 HLA058 1 97407534 97409154 ERV_0098789 HERVL-int,MLT2A2LI 0.00 2.45 300.00 HLA058 1 97765650 97767760 ERV_0099129MLT1H,MLT1H-int LIL 0.84 2.28 2.70 HLA072 1 97765650 97767760ERV_0099129 MLT1H,MLT1H-int LIL 0.09 3.48 40.77 HLA078 1 1E+08 1E+08ERV_0101272 THE1B,THE1B-int LI 0.09 3.16 35.53 HLA058 1 1.02E+081.02E+08 ERV_0103119 THE1D,THE1D-int LIL 0.00 2.08 300.00 HLA053 11.08E+08 1.08E+08 ERV_0107695 MamGyp-int I 0.56 3.46 6.20 HLA082 11.08E+08 1.08E+08 ERV_0107695 MamGyp-int I 0.49 1.86 3.78 HLA072 11.09E+08 1.09E+08 ERV_0108082 MER50-int I 0.00 1.90 300.00 HLA053 11.1E+08 1.1E+08 ERV_0109261 HERVK11-int,MER11A LIL 0.43 2.34 5.42 HLA0711 1.1E+08 1.1E+08 ERV_0109261 HERVK11-int,MER11A LIL 1.67 4.77 2.86HLA078 1 1.1E+08 1.1E+08 ERV_0109261 HERVK11-int,MER11A LIL 0.29 1.535.19 HLA053 1 1.11E+08 1.11E+08 ERV_0110695 ERVL-E-int,LTR33 LI 0.542.56 4.71 HLA076 1 1.11E+08 1.11E+08 ERV_0110695 ERVL-E-int,LTR33 LI0.62 1.67 2.69 HLA065 1 1.13E+08 1.13E+08 ERV_0112431 MER31-int,MER31ALI 0.74 2.04 2.75 HLA058 1 1.18E+08 1.18E+08 ERV_0116684 MSTA,MSTA-intLIL 0.21 1.92 9.09 HLA078 1 1.18E+08 1.18E+08 ERV_0116684 MSTA,MSTA-intLIL 0.28 1.59 5.64 HLA058 1 1.19E+08 1.19E+08 ERV_0117849HERV9NC-int,LTR12C LIL 0.71 2.16 3.06 HLA058 1 1.2E+08 1.2E+08ERV_0118349 ERVL-B4-int,MLT2D LI 0.00 1.64 300.00 HLA058 1 1.2E+081.2E+08 ERV_0118835 PRIMA4-int I 0.37 1.68 4.59 HLA065 1 1.2E+08 1.2E+08ERV_0118835 PRIMA4-int I 0.79 1.78 2.24 HLA078 1 1.2E+08 1.2E+08ERV_0118933 ERVL-E-int,LTR33 LI 2.23 8.82 3.95 HLA066 1 1.21E+081.21E+08 ERV_0119810 ERVL-B4-int I 0.00 4.48 300.00 HLA072 1 1.21E+081.21E+08 ERV_0119892 MER89-int I 0.00 3.93 300.00 HLA058 1 1.21E+081.21E+08 ERV_0119893 ERV24_Prim-int I 0.30 1.58 5.20 HLA067 1 1.21E+081.21E+08 ERV_0119893 ERV24_Prim-int I 1.20 2.92 2.43 HLA072 1 1.21E+081.21E+08 ERV_0119893 ERV24_Prim-int I 0.06 1.98 33.45 HLA067 1 1.22E+081.22E+08 ERV_0119903 HERV9N-int,LTR12_ LIL 1.09 2.44 2.23 HLA063 11.44E+08 1.44E+08 ERV_0120563 LTR49,LTR49-int LI 1.25 6.24 4.98 HLA071 11.44E+08 1.44E+08 ERV_0120563 LTR49,LTR49-int LI 1.20 7.74 6.43 HLA073 11.44E+08 1.44E+08 ERV_0120563 LTR49,LTR49-int LI 1.38 5.78 4.18 HLA076 11.44E+08 1.44E+08 ERV_0120563 LTR49,LTR49-int LI 0.81 2.26 2.80 HLA065 11.44E+08 1.44E+08 ERV_0121217 MLT1E3,MLT1E3-int LI 1.32 6.67 5.04 HLA0671 1.44E+08 1.44E+08 ERV_0121217 MLT1E3,MLT1E3-int LI 3.72 13.70 3.68HLA069 1 1.44E+08 1.44E+08 ERV_0121217 MLT1E3,MLT1E3-int LI 2.40 5.122.13 HLA078 1 1.44E+08 1.44E+08 ERV_0121217 MLT1E3,MLT1E3-int LI 1.5416.07 10.41 HLA053 1 1.45E+08 1.45E+08 ERV_0121918 MER66-int,MER66C LI1.44 6.90 4.80 HLA058 1 1.45E+08 1.45E+08 ERV_0121918 MER66-int,MER66CLI 0.78 2.30 2.96 HLA066 1 1.45E+08 1.45E+08 ERV_0121918MER66-int,MER66C LI 0.26 2.51 9.48 HLA072 1 1.45E+08 1.45E+08ERV_0121918 MER66-int,MER66C LI 0.19 2.45 12.90 HLA053 1 1.45E+081.45E+08 ERV_0121920 MER66-int I 0.42 2.13 5.06 HLA053 1 1.45E+081.45E+08 ERV_0121923 HERVP71A-int,LTR71B LI 0.42 4.09 9.74 HLA072 11.45E+08 1.45E+08 ERV_0121923 HERVP71A-int,LTR71B LI 0.00 3.05 300.00HLA065 1 1.45E+08 1.45E+08 ERV_0122124 MLT1E3,MLT1E3-int LI 2.93 12.324.21 HLA067 1 1.45E+08 1.45E+08 ERV_0122124 MLT1E3,MLT1E3-int LI 9.2426.76 2.90 HLA069 1 1.45E+08 1.45E+08 ERV_0122124 MLT1E3,MLT1E3-int LI3.33 6.77 2.03 HLA078 1 1.45E+08 1.45E+08 ERV_0122124 MLT1E3,MLT1E3-intLI 4.04 24.45 6.05 HLA058 1 1.46E+08 1.46E+08 ERV_0122759MER4B,MER4B-int LI 0.16 4.95 30.94 HLA061 1 1.46E+08 1.46E+08ERV_0122759 MER4B,MER4B-int LI 0.59 10.96 18.69 HLA072 1 1.46E+081.46E+08 ERV_0122759 MER4B,MER4B-int LI 0.17 2.52 14.44 HLA073 11.46E+08 1.46E+08 ERV_0122759 MER4B,MER4B-int LI 0.13 1.82 13.48 HLA0781 1.46E+08 1.46E+08 ERV_0122759 MER4B,MER4B-int LI 0.13 6.71 50.84HLA058 1 1.46E+08 1.46E+08 ERV_0122761 ERVL-E-int,MLT2F LI 0.16 4.9530.94 HLA061 1 1.46E+08 1.46E+08 ERV_0122761 ERVL-E-int,MLT2F LI 0.5910.96 18.69 HLA072 1 1.46E+08 1.46E+08 ERV_0122761 ERVL-E-int,MLT2F LI0.17 2.52 14.44 HLA073 1 1.46E+08 1.46E+08 ERV_0122761 ERVL-E-int,MLT2FLI 0.13 1.82 13.48 HLA078 1 1.46E+08 1.46E+08 ERV_0122761ERVL-E-int,MLT2F LI 0.13 6.71 50.84 HLA065 1 1.47E+08 1.47E+08ERV_0123613 ERVL-E-int,LTR33 LI 1.55 3.92 2.52 HLA067 1 1.47E+081.47E+08 ERV_0123613 ERVL-E-int,LTR33 LI 4.18 14.66 3.50 HLA069 11.47E+08 1.47E+08 ERV_0123613 ERVL-E-int,LTR33 LI 2.87 7.25 2.52 HLA0781 1.47E+08 1.47E+08 ERV_0123613 ERVL-E-int,LTR33 LI 0.90 3.61 4.03HLA071 1 1.48E+08 1.48E+08 ERV_0124314 MER21-int I 0.00 2.45 300.00HLA076 1 1.48E+08 1.48E+08 ERV_0124314 MER21-int I 0.00 5.89 300.00HLA078 1 1.48E+08 1.48E+08 ERV_0124314 MER21-int I 0.00 3.78 300.00HLA067 1 1.48E+08 1.48E+08 ERV_0124584 MLT1E2,MLT1E2-int LI 2.19 7.953.63 HLA073 1 1.48E+08 1.48E+08 ERV_0124584 MLT1E2,MLT1E2-int LI 1.753.82 2.18 HLA076 1 1.48E+08 1.48E+08 ERV_0124584 MLT1E2,MLT1E2-int LI2.52 10.59 4.21 HLA078 1 1.48E+08 1.48E+08 ERV_0124584 MLT1E2,MLT1E2-intLI 0.29 5.08 17.67 HLA071 1 1.48E+08 1.48E+08 ERV_0124695ERV24_Prim-int,MER87 LI 0.07 1.83 25.09 HLA078 1 1.48E+08 1.48E+08ERV_0124695 ERV24_Prim-int,MER87 LI 0.00 2.12 300.00 HLA078 1 1.48E+081.48E+08 ERV_0124778 LOR1-int,LOR1b LI 0.00 5.42 300.00 HLA065 11.48E+08 1.48E+08 ERV_0124799 MLT1E2,MLT1E2-int LI 0.00 1.51 300.00HLA067 1 1.49E+08 1.49E+08 ERV_0125432 MLT1E3,MLT1E3-int LI 12.93 26.482.05 HLA069 1 1.49E+08 1.49E+08 ERV_0125432 MLT1E3,MLT1E3-int LI 4.509.71 2.16 HLA078 1 1.49E+08 1.49E+08 ERV_0125432 MLT1E3,MLT1E3-int LI4.29 22.23 5.18 HLA072 1 1.5E+08 1.5E+08 ERV_0125913 ERVL-E-int I 0.221.57 7.02 HLA072 1 1.5E+08 1.5E+08 ERV_0125980 LTR49,LTR49-int LI 0.421.52 3.59 HLA058 1 1.51E+08 1.51E+08 ERV_0127104 HERVK-int,LTR5_Hs LIL0.74 5.88 7.93 HLA061 1 1.51E+08 1.51E+08 ERV_0127104 HERVK-int,LTR5_HsLIL 3.54 8.32 2.35 HLA063 1 1.51E+08 1.51E+08 ERV_0127104HERVK-int,LTR5_Hs LIL 1.78 4.32 2.42 HLA066 1 1.51E+08 1.51E+08ERV_0127104 HERVK-int,LTR5_Hs LIL 0.79 4.08 5.18 HLA067 1 1.51E+081.51E+08 ERV_0127104 HERVK-int,LTR5_Hs LIL 2.19 5.76 2.63 HLA069 11.51E+08 1.51E+08 ERV_0127104 HERVK-int,LTR5_Hs LIL 1.11 2.71 2.43HLA073 1 1.51E+08 1.51E+08 ERV_0127104 HERVK-int,LTR5_Hs LIL 1.45 3.462.38 HLA078 1 1.51E+08 1.51E+08 ERV_0127104 HERVK-int,LTR5_Hs LIL 0.6613.60 20.63 HLA063 1 1.51E+08 1.51E+08 ERV_0127141 HERVK9-int,MER9a3 LI0.36 1.52 4.19 HLA065 1 1.51E+08 1.51E+08 ERV_0127674 MER41-int I 0.214.20 20.13 HLA072 1 1.51E+08 1.51E+08 ERV_0127674 MER41-int I 0.76 1.782.35 HLA078 1 1.51E+08 1.51E+08 ERV_0127674 MER41-int I 0.34 2.01 5.95HLA058 1 1.52E+08 1.52E+08 ERV_0128555 MER61-int,MER61C LI 0.00 6.04300.00 HLA078 1 1.52E+08 1.52E+08 ERV_0128555 MER61-int,MER61C LI 0.332.11 6.34 HLA058 1 1.54E+08 1.54E+08 ERV_0129907 HUERS-P3b-int,LTR9B LIL7.20 19.81 2.75 HLA066 1 1.54E+08 1.54E+08 ERV_0129907HUERS-P3b-int,LTR9B LIL 5.80 12.15 2.10 HLA073 1 1.54E+08 1.54E+08ERV_0129907 HUERS-P3b-int,LTR9B LIL 4.43 10.69 2.41 HLA078 1 1.54E+081.54E+08 ERV_0129907 HUERS-P3b-int,LTR9B LIL 7.87 22.33 2.84 HLA058 11.54E+08 1.54E+08 ERV_0129908 MER61-int I 7.20 19.81 2.75 HLA066 11.54E+08 1.54E+08 ERV_0129908 MER61-int I 5.80 12.15 2.10 HLA073 11.54E+08 1.54E+08 ERV_0129908 MER61-int I 4.43 10.69 2.41 HLA078 11.54E+08 1.54E+08 ERV_0129908 MER61-int I 7.87 22.33 2.84 HLA053 11.55E+08 1.55E+08 ERV_0131153 HERV9NC-int,LTR12C LIL 0.13 2.04 15.25HLA058 1 1.55E+08 1.55E+08 ERV_0131153 HERV9NC-int,LTR12C LIL 0.06167.41 2788.25 HLA069 1 1.55E+08 1.55E+08 ERV_0131153 HERV9NC-int,LTR12CLIL 0.00 89.94 300.00 HLA071 1 1.55E+08 1.55E+08 ERV_0131153HERV9NC-int,LTR12C LIL 0.71 12.60 17.84 HLA078 1 1.55E+08 1.55E+08ERV_0131153 HERV9NC-int,LTR12C LIL 0.01 8.24 1412.03 HLA082 1 1.55E+081.55E+08 ERV_0131153 HERV9NC-int,LTR12C LIL 0.42 59.02 141.46 HLA063 11.55E+08 1.55E+08 ERV_0131872 MER41-int, MER41A,MER41B LIL 0.00 2.06300.00 HLA067 1 1.55E+08 1.55E+08 ERV_0131872 MER41-int, MER41A,MER41BLIL 0.00 3.09 300.00 HLA072 1 1.55E+08 1.55E+08 ERV_0131872 MER41-int,MER41A,MER41B LIL 0.72 4.22 5.84 HLA078 1 1.55E+08 1.55E+08 ERV_0131872MER41-int, MER41A,MER41B LIL 0.33 1.97 5.94 HLA063 1 1.55E+08 1.55E+08ERV_0131873 MER41-int I 0.00 2.06 300.00 HLA067 1 1.55E+08 1.55E+08ERV_0131873 MER41-int I 0.00 3.09 300.00 HLA072 1 1.55E+08 1.55E+08ERV_0131873 MER41-int I 0.72 4.22 5.84 HLA078 1 1.55E+08 1.55E+08ERV_0131873 MER41-int I 0.33 1.97 5.94 HLA053 1 1.58E+08 1.58E+08ERV_0134296 THE1D,THE1D-int LIL 0.13 2.67 20.00 HLA069 1 1.58E+081.58E+08 ERV_0134740 MER57A-int,MER57C1 LI 0.28 1.99 7.05 HLA069 11.58E+08 1.58E+08 ERV_0134742 MER34B-int I 0.28 1.99 7.05 HLA058 11.59E+08 1.59E+08 ERV_0135678 ERV3-16A3_I-int, ERV3-16A3_LTR LI 0.001.59 300.00 HLA071 1 1.59E+08 1.59E+08 ERV_0135678 ERV3-16A3_I-int,ERV3-16A3_LTR LI 0.56 4.86 8.64 HLA076 1 1.59E+08 1.59E+08 ERV_0135678ERV3-16A3_I-int, ERV3-16A3_LTR LI 0.00 2.01 300.00 HLA067 1 1.61E+081.61E+08 ERV_0136991 ERVL-E-int I 0.00 1.70 300.00 HLA058 1 1.62E+081.62E+08 ERV_0137703 MER34B-int,MER57F LIL 2.61 6.45 2.47 HLA066 11.62E+08 1.62E+08 ERV_0137703 MER34B-int,MER57F LIL 2.16 12.89 5.97HLA078 1 1.62E+08 1.62E+08 ERV_0137703 MER34B-int,MER57F LIL 8.24 54.006.56 HLA058 1 1.62E+08 1.62E+08 ERV_0137704 MER34-int I 2.61 6.45 2.47HLA066 1 1.62E+08 1.62E+08 ERV_0137704 MER34-int I 2.16 12.89 5.97HLA078 1 1.62E+08 1.62E+08 ERV_0137704 MER34-int I 8.24 54.00 6.56HLA058 1 1.62E+08 1.62E+08 ERV_0137705 MER57-int I 2.61 6.45 2.47 HLA0661 1.62E+08 1.62E+08 ERV_0137705 MER57-int I 2.16 12.89 5.97 HLA078 11.62E+08 1.62E+08 ERV_0137705 MER57-int I 8.24 54.00 6.56 HLA058 11.62E+08 1.62E+08 ERV_0137783 MER34B-int,MER57F LIL 1.14 7.75 6.81HLA066 1 1.62E+08 1.62E+08 ERV_0137783 MER34B-int,MER57F LIL 0.80 7.479.29 HLA078 1 1.62E+08 1.62E+08 ERV_0137783 MER34B-int,MER57F LIL 1.4412.54 8.74 HLA058 1 1.62E+08 1.62E+08 ERV_0137784 LTR57-int I 1.14 7.756.81 HLA066 1 1.62E+08 1.62E+08 ERV_0137784 LTR57-int I 0.80 7.47 9.29HLA078 1 1.62E+08 1.62E+08 ERV_0137784 LTR57-int I 1.44 12.54 8.74HLA058 1 1.62E+08 1.62E+08 ERV_0137785 MER34-int I 1.14 7.75 6.81 HLA0661 1.62E+08 1.62E+08 ERV_0137785 MER34-int I 0.80 7.47 9.29 HLA078 11.62E+08 1.62E+08 ERV_0137785 MER34-int I 1.44 12.54 8.74 HLA058 11.62E+08 1.62E+08 ERV_0137786 MER57-int I 1.14 7.75 6.81 HLA066 11.62E+08 1.62E+08 ERV_0137786 MER57-int I 0.80 7.47 9.29 HLA078 11.62E+08 1.62E+08 ERV_0137786 MER57-int I 1.44 12.54 8.74 HLA058 11.68E+08 1.68E+08 ERV_0143869 ERV3-16A3_I-int I 0.00 2.70 300.00 HLA0581 1.68E+08 1.68E+08 ERV_0143903 MSTA,MSTA-int LIL 0.53 2.69 5.10 HLA0671 1.7E+08 1.7E+08 ERV_0145224 THE1B,THE1B-int LIL 0.79 6.27 7.99 HLA0691 1.7E+08 1.7E+08 ERV_0145224 THE1B,THE1B-int LIL 5.22 31.40 6.01 HLA0711 1.7E+08 1.7E+08 ERV_0145224 THE1B,THE1B-int LIL 3.16 7.43 2.35 HLA0731 1.7E+08 1.7E+08 ERV_0145224 THE1B,THE1B-int LIL 2.09 10.92 5.23 HLA0761 1.7E+08 1.7E+08 ERV_0145224 THE1B,THE1B-int LIL 2.92 18.50 6.34 HLA0781 1.7E+08 1.7E+08 ERV_0145224 THE1B,THE1B-int LIL 2.20 10.65 4.84 HLA0631 1.71E+08 1.71E+08 ERV_0146196 PRIMA4-int I 1.73 5.86 3.40 HLA067 11.71E+08 1.71E+08 ERV_0146196 PRIMA4-int I 2.85 8.85 3.11 HLA065 11.71E+08 1.71E+08 ERV_0146200 MLT1D,MLT1D-int LI 4.44 19.81 4.46 HLA0671 1.71E+08 1.71E+08 ERV_0146200 MLT1D,MLT1D-int LI 66.35 182.81 2.76HLA071 1 1.71E+08 1.71E+08 ERV_0146200 MLT1D,MLT1D-int LI 66.87 159.962.39 HLA073 1 1.71E+08 1.71E+08 ERV_0146200 MLT1D,MLT1D-int LI 36.57116.54 3.19 HLA078 1 1.73E+08 1.73E+08 ERV_0147624HERV9N-int,LTR12,LTR12_ LIL 0.01 1.75 158.70 HLA078 1 1.73E+08 1.73E+08ERV_0147625 HERV9-int I 0.01 1.75 158.70 HLA065 1 1.73E+08 1.73E+08ERV_0148108 ERVL-B4-int,MLT2B1 LI 0.07 3.33 47.45 HLA072 1 1.73E+081.73E+08 ERV_0148108 ERVL-B4-int,MLT2B1 LI 0.50 2.13 4.29 HLA053 11.73E+08 1.73E+08 ERV_0148199 PABL_A-int I 0.05 3.36 66.32 HLA069 11.73E+08 1.73E+08 ERV_0148199 PABL_A-int I 0.58 2.02 3.48 HLA076 11.73E+08 1.73E+08 ERV_0148199 PABL_A-int I 3.14 6.51 2.07 HLA078 11.73E+08 1.73E+08 ERV_0148199 PABL_A-int I 0.54 1.71 3.15 HLA066 11.8E+08 1.8E+08 ERV_0153998 MLT1-int I 0.54 2.20 4.06 HLA061 1 1.82E+081.82E+08 ERV_0156094 ERVL-B4-int I 0.00 2.05 300.00 HLA078 1 1.82E+081.82E+08 ERV_0156094 ERVL-B4-int I 0.00 34.38 300.00 HLA071 1 1.85E+081.85E+08 ERV_0157983 MLT1D,MLT1D-int LI 1.08 2.64 2.46 HLA053 1 1.87E+081.87E+08 ERV_0159933 HERVH-int,LTR7 LI 0.69 1.87 2.68 HLA065 1 1.87E+081.87E+08 ERV_0159933 HERVH-int,LTR7 LI 0.69 1.89 2.73 HLA078 1 1.88E+081.88E+08 ERV_0160543 MER61-int,MER61A LI 0.00 1.58 300.00 HLA066 11.9E+08 1.9E+08 ERV_0162375 MLTII,MLTII-int LIL 0.00 3.85 300.00 HLA0821 1.9E+08 1.9E+08 ERV_0162375 MLTII,MLTII-int LIL 0.00 1.75 300.00HLA058 1 1.91E+08 1.91E+08 ERV_0163486 MLTIJ-int I 0.00 4.94 300.00HLA058 1 1.91E+08 1.91E+08 ERV_0163528 MLT1A,MLT1A-int LI 0.00 5.92300.00 HLA058 1 1.91E+08 1.91E+08 ERV_0163540 MLT1G3,MLT1G3-int LI 0.003.47 300.00 HLA058 1 1.93E+08 1.93E+08 ERV_0164496 ERV3-16A3-I-int,LTR16LI 0.00 1.66 300.00 HLA065 1 1.94E+08 1.94E+08 ERV_0165789 ERVL-B4-int I0.00 3.04 300.00 HLA082 1 1.94E+08 1.94E+08 ERV_0165789 ERVL-B4-int I0.00 1.53 300.00 HLA067 1 1.96E+08 1.96E+08 ERV_0167468 LTR53-int I 0.001.61 300.00 HLA072 1 1.96E+08 1.96E+08 ERV_0167468 LTR53-int I 0.25 1.807.20 HLA063 1 1.97E+08 1.97E+08 ERV_0167859 HUERS-P1-int I 159.08 509.203.20 HLA065 1 1.97E+08 1.97E+08 ERV_0167861 PABL_B-int I 5.20 45.54 8.76HLA067 1 1.97E+08 1.97E+08 ERV_0167861 PABL_B-int I 8.62 45.42 5.27HLA072 1 1.97E+08 1.97E+08 ERV_0167861 PABL_B-int I 10.26 28.52 2.78HLA065 1 1.97E+08 1.97E+08 ERV_0167863 MER84-int I 0.00 2.10 300.00HLA072 1 1.97E+08 1.97E+08 ERV_0167863 MER84-int I 1.37 3.34 2.44 HLA0821 1.97E+08 1.97E+08 ERV_0167863 MER84-int I 1.22 12.87 10.56 HLA067 11.97E+08 1.97E+08 ERV_0167920 THE1B,THE1B-int LIL 32.07 124.92 3.90HLA067 1 1.97E+08 1.97E+08 ERV_0167929 MER4B-int I 0.07 4.60 62.89HLA067 1 1.97E+08 1.97E+08 ERV_0167930 ERVL-E-int I 0.00 2.92 300.00HLA065 1 1.97E+08 1.97E+08 ERV_0168018 THE1B,THE1B-int LIL 4.16 10.032.41 HLA067 1 1.97E+08 1.97E+08 ERV_0168018 THE1B,THE1B-int LIL 22.2078.52 3.54 HLA067 1 1.97E+08 1.97E+08 ERV_0168028 ERVL-E-int I 0.00 2.00300.00 HLA061 1 1.97E+08 1.97E+08 ERV_0168046 MER21-int I 28.39 79.132.79 HLA067 1 1.97E+08 1.97E+08 ERV_0168046 MER21-int I 17.88 72.46 4.05HLA076 1 1.97E+08 1.97E+08 ERV_0168046 MER21-int I 3.78 47.56 12.58HLA053 1 1.97E+08 1.97E+08 ERV_0168088 MER4B-int I 0.47 12.89 27.28HLA065 1 1.97E+08 1.97E+08 ERV_0168088 MER4B-int I 0.50 5.17 10.44HLA067 1 1.97E+08 1.97E+08 ERV_0168088 MER4B-int I 5.38 12.30 2.29HLA069 1 1.97E+08 1.97E+08 ERV_0168088 MER4B-int I 6.08 17.84 2.94HLA076 1 1.97E+08 1.97E+08 ERV_0168088 MER4B-int I 4.32 74.23 17.17HLA078 1 1.97E+08 1.97E+08 ERV_0168088 MER4B-int I 10.23 58.37 5.71HLA082 1 1.97E+08 1.97E+08 ERV_0168088 MER4B-int I 4.90 14.73 3.01HLA053 1 1.97E+08 1.97E+08 ERV_0168090 ERVL47-int,LTR47A LI 0.47 12.8927.28 HLA065 1 1.97E+08 1.97E+08 ERV_0168090 ERVL47-int,LTR47A LI 0.505.17 10.44 HLA067 1 1.97E+08 1.97E+08 ERV_0168090 ERVL47-int,LTR47A LI5.38 12.30 2.29 HLA069 1 1.97E+08 1.97E+08 ERV_0168090 ERVL47-int,LTR47ALI 6.08 17.84 2.94 HLA076 1 1.97E+08 1.97E+08 ERV_0168090ERVL47-int,LTR47A LI 4.32 74.23 17.17 HLA078 1 1.97E+08 1.97E+08ERV_0168090 ERVL47-int,LTR47A LI 10.23 58.37 5.71 HLA082 1 1.97E+081.97E+08 ERV_0168090 ERVL47-int,LTR47A LI 4.90 14.73 3.01 HLA071 12.04E+08 2.04E+08 ERV_0175026 MER101-int I 0.13 1.91 15.03 HLA073 12.04E+08 2.04E+08 ERV_0175026 MER101-int I 0.13 1.79 13.67 HLA071 12.04E+08 2.04E+08 ERV_0175028 LOR1-int I 0.13 1.91 15.03 HLA073 12.04E+08 2.04E+08 ERV_0175028 LOR1-int I 0.13 1.79 13.67 HLA071 12.04E+08 2.04E+08 ERV_0175030 LOR1-int I 0.00 2.16 300.00 HLA073 12.04E+08 2.04E+08 ERV_0175030 LOR1-int I 0.00 1.63 300.00 HLA065 12.04E+08 2.04E+08 ERV_0175089 MLT1C,MLT1C-int LIL 1.48 8.90 6.01 HLA0671 2.04E+08 2.04E+08 ERV_0175089 MLT1C,MLT1C-int LIL 2.25 5.85 2.60HLA072 1 2.04E+08 2.04E+08 ERV_0175089 MLT1C,MLT1C-int LIL 2.70 6.812.53 HLA073 1 2.04E+08 2.04E+08 ERV_0175089 MLT1C,MLT1C-int LIL 0.721.97 2.75 HLA078 1 2.04E+08 2.04E+08 ERV_0175089 MLT1C,MLT1C-int LIL0.90 2.54 2.83 HLA065 1 2.04E+08 2.04E+08 ERV_0175090 MLT1C-int I 1.488.90 6.01 HLA067 1 2.04E+08 2.04E+08 ERV_0175090 MLT1C-int I 2.25 5.852.60 HLA072 1 2.04E+08 2.04E+08 ERV_0175090 MLT1C-int I 2.70 6.81 2.53HLA073 1 2.04E+08 2.04E+08 ERV_0175090 MLT1C-int I 0.72 1.97 2.75 HLA0781 2.04E+08 2.04E+08 ERV_0175090 MLT1C-int I 0.90 2.54 2.83 HLA053 12.06E+08 2.06E+08 ERV_0176824 HERVK9-int,MER9a2 LIL 0.07 6.66 91.55HLA058 1 2.06E+08 2.06E+08 ERV_0176824 HERVK9-int,MER9a2 LIL 1.66 3.662.20 HLA065 1 2.06E+08 2.06E+08 ERV_0176824 HERVK9-int,MER9a2 LIL 1.382.90 2.10 HLA067 1 2.06E+08 2.06E+08 ERV_0176824 HERVK9-int,MER9a2 LIL1.00 9.17 9.20 HLA078 1 2.06E+08 2.06E+08 ERV_0176824 HERVK9-int,MER9a2LIL 0.74 6.31 8.56 HLA058 1 2.06E+08 2.06E+08 ERV_0176962Harlequin-int,LTR2B LIL 9.32 22.55 2.42 HLA065 1 2.06E+08 2.06E+08ERV_0176962 Harlequin-int,LTR2B LIL 7.69 23.62 3.07 HLA078 1 2.07E+082.07E+08 ERV_0178018 HERV3-int,LTR61 LI 0.00 2.19 300.00 HLA063 12.07E+08 2.07E+08 ERV_0178111 MLT1J-int I 0.52 2.34 4.47 HLA067 12.11E+08 2.11E+08 ERV_0181638 HERVK11-int,MER11C LI 2.73 6.97 2.55HLA069 1 2.11E+08 2.11E+08 ERV_0181638 HERVK11-int,MER11C LI 0.59 2.263.84 HLA076 1 2.11E+08 2.11E+08 ERV_0181638 HERVK11-int,MER11C LI 0.881.96 2.22 HLA078 1 2.11E+08 2.11E+08 ERV_0181638 HERVK11-int,MER11C LI1.18 4.41 3.73 HLA078 1 2.14E+08 2.14E+08 ERV_0183758 THE1B,THE1B-intLIL 0.00 6.10 300.00 HLA065 1 2.14E+08 2.14E+08 ERV_0184071MLT1H1,MLT1H1-int LI 1.11 11.27 10.14 HLA066 1 2.14E+08 2.14E+08ERV_0184071 MLT1H1,MLT1H1-int LI 0.90 2.70 3.01 HLA067 1 2.14E+082.14E+08 ERV_0184071 MLT1H1,MLT1H1-int LI 0.59 4.04 6.84 HLA072 12.14E+08 2.14E+08 ERV_0184071 MLT1H1,MLT1H1-int LI 1.03 7.03 6.83 HLA0781 2.18E+08 2.18E+08 ERV_0187236 MLT1J,MLTIJ-int LI 0.00 1.70 300.00HLA061 1 2.19E+08 2.19E+08 ERV_0188579 THE1A,THE1A-int LI 0.77 1.61 2.10HLA063 1 2.19E+08 2.19E+08 ERV_0188579 THE1A,THE1A-int LI 0.36 1.94 5.37HLA067 1 2.19E+08 2.19E+08 ERV_0188579 THE1A,THE1A-int LI 0.67 3.31 4.92HLA078 1 2.19E+08 2.19E+08 ERV_0188579 THE1A,THE1A-int LI 1.14 8.53 7.50HLA078 1 2.2E+08 2.2E+08 ERV_0189629 MLT1J2,MLT1J2-int LIL 0.00 6.87300.00 HLA058 1 2.23E+08 2.23E+08 ERV_0192066 HERVP71A-int,LTR71B LI0.14 1.74 12.69 HLA076 1 2.25E+08 2.25E+08 ERV_0193956 ERVL-B4-int I0.00 1.74 300.00 HLA065 1 2.28E+08 2.28E+08 ERV_0196301 ERVL-int I 0.001.61 300.00 HLA058 1 2.28E+08 2.28E+08 ERV_0196345 Harlequin-int,LTR2 LI2.89 10.13 3.50 HLA069 1 2.28E+08 2.28E+08 ERV_0196345Harlequin-int,LTR2 LI 4.11 8.24 2.00 HLA071 1 2.28E+08 2.28E+08ERV_0196345 Harlequin-int,LTR2 LI 3.71 8.35 2.25 HLA072 1 2.28E+082.28E+08 ERV_0196345 Harlequin-int,LTR2 LI 4.24 10.43 2.46 HLA078 12.28E+08 2.28E+08 ERV_0196345 Harlequin-int,LTR2 LI 1.61 10.69 6.63HLA061 1 2.34E+08 2.34E+08 ERV_0201504 MLT1A0,MLT1A0-int LI 0.43 1.754.11 HLA078 1 2.35E+08 2.35E+08 ERV_0202266 HERV17-int I 0.00 1.69300.00 HLA076 1 2.36E+08 2.36E+08 ERV_0204120 THE1A,THE1A-int LIL 0.083.07 36.69 HLA078 1 2.36E+08 2.36E+08 ERV_0204120 THE1A,THE1A-int LIL0.24 1.57 6.53 HLA065 1 2.36E+08 2.36E+08 ERV_0204212 MLT1K,MLT1K-int LI1.08 2.55 2.36 HLA069 1 2.36E+08 2.36E+08 ERV_0204212 MLT1K,MLT1K-int LI0.00 2.08 300.00 HLA082 1 2.37E+08 2.37E+08 ERV_0204667 MLT1A,MLT1A-intLI 0.00 1.71 300.00 HLA078 1 2.4E+08 2.4E+08 ERV_0207418 THE1B,THE1B-intLI 0.00 1.83 300.00 HLA067 1 2.4E+08 2.4E+08 ERV_0208012 E RV3-16A3-1 -int, LTR 16 LI 1.29 3.12 2.41 HLA076 1 2.4E+08 2.4E+08 ERV_0208012 ERV3-16A3-1 -i nt, LTR 16 LI 0.09 4.64 52.87 HLA053 1 2.44E+08 2.44E+08ERV_0211765 MER50,MER50-int LI 0.16 1.54 9.65 HLA065 1 2.45E+08 2.45E+08ERV_0212111 MER68,MER68-int LI 1.18 3.85 3.25 HLA067 1 2.45E+08 2.45E+08ERV_0212111 MER68,MER68-int LI 0.67 1.83 2.74 HLA078 1 2.45E+08 2.45E+08ERV_0212111 MER68,MER68-int LI 0.51 1.67 3.29 HLA065 1 2.45E+08 2.45E+08ERV_0212115 MER68,MER68-int LI 1.18 3.85 3.25 HLA067 1 2.45E+08 2.45E+08ERV_0212115 MER68,MER68-int LI 0.67 1.83 2.74 HLA078 1 2.45E+08 2.45E+08ERV_0212115 MER68,MER68-int LI 0.51 1.67 3.29 HLA065 1 2.45E+08 2.45E+08ERV_0212118 MLT1-int I 1.18 3.85 3.25 HLA067 1 2.45E+08 2.45E+08ERV_0212118 MLT1-int I 0.67 1.83 2.74 HLA078 1 2.45E+08 2.45E+08ERV_0212118 MLT1-int I 0.51 1.67 3.29 HLA072 1 2.46E+08 2.46E+08ERV_0213461 HUERS-P3-int,LTR9 LIL 0.14 4.59 32.62 HLA053 1 2.47E+082.47E+08 ERV_0214472 HERVK14C-int,LTR14C LI 0.69 1.73 2.50 HLA058 12.47E+08 2.47E+08 ERV_0214472 HERVK14C-int,LTR14C LI 0.47 1.98 4.22HLA061 1 2.47E+08 2.47E+08 ERV_0214472 HERVK14C-int,LTR14C LI 0.32 4.0112.45 HLA065 1 2.47E+08 2.47E+08 ERV_0214472 HERVK14C-int,LTR14C LI 0.552.34 4.29 HLA069 1 2.47E+08 2.47E+08 ERV_0214472 HERVK14C-int,LTR14C LI0.18 1.56 8.66 HLA071 1 2.47E+08 2.47E+08 ERV_0214472HERVK14C-int,LTR14C LI 1.08 3.31 3.06 HLA078 1 2.47E+08 2.47E+08ERV_0214472 HERVK14C-int,LTR14C LI 0.57 3.06 5.40 HLA053 1 2.47E+082.47E+08 ERV_0214473 HERVK14C-int I 0.69 1.73 2.50 HLA058 1 2.47E+082.47E+08 ERV_0214473 HERVK14C-int I 0.47 1.98 4.22 HLA061 1 2.47E+082.47E+08 ERV_0214473 HERVK14C-int I 0.32 4.01 12.45 HLA065 1 2.47E+082.47E+08 ERV_0214473 HERVK14C-int I 0.55 2.34 4.29 HLA069 1 2.47E+082.47E+08 ERV_0214473 HERVK14C-int I 0.18 1.56 8.66 HLA071 1 2.47E+082.47E+08 ERV_0214473 HERVK14C-int I 1.08 3.31 3.06 HLA078 1 2.47E+082.47E+08 ERV_0214473 HERVK14C-int I 0.57 3.06 5.40 HLA058 1 2.47E+082.47E+08 ERV_0214495 HERVL40-int I 1.11 2.72 2.45 HLA061 1 2.47E+082.47E+08 ERV_0214495 HERVL40-int I 0.58 1.78 3.08 HLA065 1 2.47E+082.47E+08 ERV_0214495 HERVL40-int I 0.72 1.94 2.70 HLA072 1 2.47E+082.47E+08 ERV_0214495 HERVL40-int I 0.50 5.82 11.68 HLA078 1 2.47E+082.47E+08 ERV_0214495 HERVL40-int I 0.28 1.64 5.85 HLA058 1 2.47E+082.47E+08 ERV_0214642 MLT1B,MLT1B-int LIL 0.53 1.52 2.87 HLA065 12.47E+08 2.47E+08 ERV_0214642 MLT1B,MLT1B-int LIL 1.12 2.56 2.29 HLA0581 2.47E+08 2.47E+08 ERV_0214643 MLT1B-int I 0.53 1.52 2.87 HLA065 12.47E+08 2.47E+08 ERV_0214643 MLT1B-int I 1.12 2.56 2.29 HLA069 12.48E+08 2.48E+08 ERV_0214828 MER89-int I 0.00 2.11 300.00 HLA053 12.49E+08 2.49E+08 ERV_0215688 MER4-int,MER4A1 LIL 0.15 3.44 22.40 HLA0671 2.49E+08 2.49E+08 ERV_0215688 MER4-int,MER4A1 LIL 0.00 1.92 300.00HLA069 1 2.49E+08 2.49E+08 ERV_0215688 MER4-int,MER4A1 LIL 0.00 8.89300.00 HLA071 1 2.49E+08 2.49E+08 ERV_0215688 MER4-int,MER4A1 LIL 0.646.35 9.99 HLA073 1 2.49E+08 2.49E+08 ERV_0215688 MER4-int,MER4A1 LIL0.00 1.75 300.00 HLA078 1 2.49E+08 2.49E+08 ERV_0215688 MER4-int,MER4A1LIL 0.00 2.58 300.00 HLA069 1 906474 906556 ERV_0216289 HERV16-int I0.12 2.99 24.50 HLA065 1 1275713 1280788 ERV_0216432 MER4B,MER4B-int LIL0.52 2.61 5.00 HLA071 1 1275713 1280788 ERV_0216432 MER4B,MER4B-int LIL2.93 10.86 3.71 HLA073 1 1275713 1280788 ERV_0216432 MER4B,MER4B-int LIL2.52 8.41 3.34 HLA078 1 1275713 1280788 ERV_0216432 MER4B,MER4B-int LIL1.30 5.16 3.97 HLA063 1 1384033 1384156 ERV_0216462 MER66-int I 2.374.83 2.03 HLA078 1 1384033 1384156 ERV_0216462 MER66-int I 0.88 3.153.57 HLA058 1 1412252 1418852 ERV_0216485 Harlequin-int,LTR2B LIL 0.333.60 11.08 HLA063 1 1412252 1418852 ERV_0216485 Harlequin-int,LTR2B LIL0.16 8.58 53.89 HLA072 1 1412252 1418852 ERV_0216485 Harlequin-int,LTR2BLIL 0.81 5.83 7.19 HLA073 1 1412252 1418852 ERV_0216485Harlequin-int,LTR2B LIL 0.07 3.30 48.16 HLA076 1 1412252 1418852ERV_0216485 Harlequin-int,LTR2B LIL 0.73 2.16 2.97 HLA078 1 14122521418852 ERV_0216485 Harlequin-int,LTR2B LIL 0.05 3.73 78.21 HLA078 11498784 1511404 ERV_0216552 HERVIP10F-int,LTR10A LIL 0.23 1.66 7.27HLA078 1 1502812 1502909 ERV_0216563 HERV9N-int I 0.23 1.66 7.27 HLA0671 1911129 1911705 ERV_0216860 ERV3-16A3_I-int,ERV3-16A3_LTR LI 1.35 3.372.49 HLA069 1 1911129 1911705 ERV_0216860 ERV3-16A3_I-int,ERV3-16A3_LTRLI 0.00 2.37 300.00 HLA073 1 1911129 1911705 ERV_0216860ERV3-16A3_I-int,ERV3-16A3_LTR LI 0.79 3.15 4.01 HLA066 1 2035564 2038368ERV_0216920 ERVL-E-int I 1.06 2.56 2.41 HLA053 1 2383456 2383681ERV_0217092 ERVL-E-int I 1.19 5.15 4.32 HLA058 1 2383456 2383681ERV_0217092 ERVL-E-int I 0.00 3.48 300.00 HLA066 1 2383456 2383681ERV_0217092 ERVL-E-int I 0.00 4.32 300.00 HLA067 1 2383456 2383681ERV_0217092 ERVL-E-int I 0.00 5.17 300.00 HLA073 1 2383456 2383681ERV_0217092 ERVL-E-int I 0.10 2.08 21.27 HLA078 1 2383456 2383681ERV_0217092 ERVL-E-int I 0.04 2.44 61.11 HLA073 1 3658269 3662728ERV_0217438 MER31-int,MER34C2 LIL 0.00 5.72 300.00 HLA078 1 36582693662728 ERV_0217438 MER31-int,MER34C2 LIL 0.00 1.90 300.00 HLA072 17790172 7792441 ERV_0220051 THE1C,THE1C-int LIL 0.37 1.83 5.01 HLA058 110137357 10137879 ERV_0222170 ERVL-int I 0.33 2.24 6.87 HLA058 116602708 16603618 ERV_0227869 ERVL-E-int,LTR33 LI 0.00 1.72 300.00HLA065 1 16602708 16603618 ERV_0227869 ERVL-E-int,LTR33 LI 4.11 11.982.91 HLA066 1 16602708 16603618 ERV_0227869 ERVL-E-int,LTR33 LI 0.791.64 2.07 HLA067 1 16602708 16603618 ERV_0227869 ERVL-E-int,LTR33 LI0.27 3.33 12.47 HLA069 1 16602708 16603618 ERV_0227869 ERVL-E-int,LTR33LI 3.92 10.36 2.64 HLA073 1 16602708 16603618 ERV_0227869ERVL-E-int,LTR33 LI 1.65 7.53 4.55 HLA076 1 16602708 16603618ERV_0227869 ERVL-E-int,LTR33 LI 1.79 5.76 3.23 HLA078 1 1660270816603618 ERV_0227869 ERVL-E-int,LTR33 LI 5.94 16.77 2.82 HLA063 119294272 19295902 ERV_0230263 HUERS-P3-int,LTR9D LI 6.67 21.82 3.27HLA067 1 19294272 19295902 ERV_0230263 HUERS-P3-int,LTR9D LI 5.55 11.122.00 HLA069 1 19294272 19295902 ERV_0230263 HUERS-P3-int,LTR9D LI 6.8914.45 2.10 HLA078 1 19294272 19295902 ERV_0230263 HUERS-P3-int,LTR9D LI3.19 9.88 3.10 HLA053 1 20598507 20603714 ERV_0231501 MLT1A,MLT1A-intLIL 1.37 10.19 7.42 HLA065 1 20598507 20603714 ERV_0231501MLT1A,MLT1A-int LIL 1.93 8.10 4.19 HLA067 1 20598507 20603714ERV_0231501 MLT1A,MLT1A-int LIL 4.88 11.97 2.45 HLA078 1 2145002121455400 ERV_0232188 MLT1E3,MLT1E3-int LIL 0.34 2.33 6.90 HLA063 124162011 24164755 ERV_0234944 MLT1E2,MLT1E2-int LI 8.29 21.43 2.59HLA065 1 24162011 24164755 ERV_0234944 MLT1E2,MLT1E2-int LI 4.63 22.974.96 HLA066 1 24162011 24164755 ERV_0234944 MLT1E2,MLT1E2-int LI 1.685.14 3.06 HLA067 1 24162011 24164755 ERV_0234944 MLT1E2,MLT1E2-int LI8.04 30.41 3.78 HLA072 1 24162011 24164755 ERV_0234944 MLT1E2,MLT1E2-intLI 4.63 18.33 3.96 HLA063 1 24165062 24165488 ERV_0234949 MLTIE2-int I8.45 20.44 2.42 HLA065 1 24165062 24165488 ERV_0234949 MLTIE2-int I 0.003.49 300.00 HLA067 1 24165062 24165488 ERV_0234949 MLT1E2-int I 8.8328.34 3.21 HLA069 1 24165062 24165488 ERV_0234949 MLT1E2-int I 1.37 7.105.18 HLA072 1 24165062 24165488 ERV_0234949 MLTIE2-int I 7.02 14.99 2.14HLA066 1 25263315 25265225 ERV_0236056 THE1B,THE1B-int LI 2.16 5.05 2.34HLA067 1 25263315 25265225 ERV_0236056 THE1B,THE1B-int LI 1.98 7.43 3.76HLA072 1 25263315 25265225 ERV_0236056 THE1B,THE1B-int LI 7.42 19.422.62 HLA078 1 25263315 25265225 ERV_0236056 THE1B,THE1B-int LI 3.69 9.582.60 HLA065 1 25333641 25335551 ERV_0236135 THE1B,THE1B-int LI 3.27 9.592.93 HLA066 1 25333641 25335551 ERV_0236135 THE1B,THE1B-int LI 2.33 5.392.32 HLA067 1 25333641 25335551 ERV_0236135 THE1B,THE1B-int LI 1.09 2.592.38 HLA078 1 25333641 25335551 ERV_0236135 THE1B,THE1B-int LI 0.48 3.226.69 HLA072 1 25854336 25855305 ERV_0236655 MLT1F,MLT1F-int LI 0.00 1.66300.00 HLA082 1 26802679 26809760 ERV_0237631 MLT1J2,MLT1J2-int LI 0.234.96 21.36 HLA053 1 26933800 26934662 ERV_0237780 THE1C,THE1C-int LIL4.44 9.88 2.22 HLA058 1 26933800 26934662 ERV_0237780 THE1C,THE1C-intLIL 4.31 9.55 2.22 HLA076 1 26933800 26934662 ERV_0237780THE1C,THE1C-int LIL 4.11 9.58 2.33 HLA078 1 26933800 26934662ERV_0237780 THE1C,THE1C-int LIL 4.98 10.68 2.15 HLA078 1 2781578827817699 ERV_0238711 MER21-int I 0.16 3.51 22.46 HLA061 1 2858690728589810 ERV_0239574 Harlequin-int,LTR2B LI 0.38 1.51 3.92 HLA078 131453515 31457948 ERV_0242310 HERVIP10F-int,LTR10A LI 0.13 29.74 221.97HLA071 1 31467354 31471933 ERV_0242312 HERVIP10F-int,LTR10A LI 0.28 2.619.17 HLA078 1 31467354 31471933 ERV_0242312 HERVIP10F-int,LTR10A LI 0.2241.43 184.92 HLA078 1 31472400 31474977 ERV_0242316 THE1A,THE1A-int LIL0.00 4.70 300.00 HLA058 1 32141732 32141852 ERV_0242926 LOR1-int I 0.002.66 300.00 HLA072 1 32141732 32141852 ERV_0242926 LOR1-int I 0.06 1.8832.29 HLA078 1 32141732 32141852 ERV_0242926 LOR1-int I 0.00 1.62 300.00HLA067 1 32928071 32931352 ERV_0243767 ERVL-E-int I 1.05 2.78 2.64HLA078 1 32928071 32931352 ERV_0243767 ERVL-E-int I 0.94 3.03 3.21HLA072 1 33283860 33286875 ERV_0244094 LTR37-int I 0.56 1.76 3.15 HLA0671 35271325 35271364 ERV_0245545 LTR57-int I 0.00 1.56 300.00 HLA058 138977684 38979895 ERV_0248587 HERV9N-int,LTR12 LI 1.00 5.06 5.08 HLA0651 43246702 43251577 ERV_0252288 LOR1-int,LOR1b LI 1.19 3.06 2.57 HLA0671 43246702 43251577 ERV_0252288 LOR1-int,LOR1b LI 9.41 19.03 2.02 HLA0651 43246769 43250804 ERV_0252289 LOR1-int I 1.19 3.06 2.57 HLA067 143246769 43250804 ERV_0252289 LOR1-int I 9.41 19.03 2.02 HLA065 143761082 43765435 ERV_0252707 MLT1J2,MLT1J2-int LI 0.48 1.91 3.96 HLA0721 43761082 43765435 ERV_0252707 MLT1J2,MLT1J2-int LI 0.28 2.64 9.39HLA058 1 45083697 45086348 ERV_0253755 MSTA,MSTA-int LIL 0.17 2.23 13.13HLA061 1 45083697 45086348 ERV_0253755 MSTA,MSTA-int LIL 0.47 4.24 9.06HLA053 1 45222079 45229003 ERV_0253857 ERVL-E-int,LTR41 LI 0.16 1.519.63 HLA071 1 45222079 45229003 ERV_0253857 ERVL-E-int,LTR41 LI 0.502.23 4.48 HLA078 1 45222079 45229003 ERV_0253857 ERVL-E-int,LTR41 LI0.01 6.53 545.16 HLA058 1 45575881 45580362 ERV_0254173 MER61-int I 0.573.29 5.72 HLA069 1 45575881 45580362 ERV_0254173 MER61-int I 0.19 1.919.90 HLA065 1 45896768 45899211 ERV_0254500 MER21-int I 0.23 2.44 10.74HLA058 1 46372033 46373850 ERV_0254932 MSTC,MSTC-int LI 0.27 1.62 6.04HLA061 1 47162601 47164328 ERV_0255410 MLT1D,MLT1D-int LIL 0.19 9.5850.44 HLA061 1 47164329 47164452 ERV_0255411 MLT1D-int I 0.00 1.67300.00 HLA072 1 47393395 47393603 ERV_0255621 HERV35I-int I 0.00 6.54300.00 HLA072 1 47393602 47393844 ERV_0255622 MER41-int,MER41B LI 0.006.54 300.00 HLA065 1 51861646 51862212 ERV_0258935 MER57A-int I 0.003.29 300.00 HLA078 1 51861646 51862212 ERV_0258935 MER57A-int I 0.002.07 300.00 HLA067 1 54164134 54166960 ERV_0261073 THE1A,THE1A-int LIL0.82 1.72 2.10 HLA072 1 54164134 54166960 ERV_0261073 THE1A,THE1A-intLIL 0.68 1.89 2.79 HLA073 1 54164134 54166960 ERV_0261073THE1A,THE1A-int LIL 0.25 2.06 8.08 HLA078 1 54164134 54166960ERV_0261073 THE1A,THE1A-int LIL 0.61 1.99 3.28 HLA072 1 5687311556873184 ERV_0263370 ERVL-E-int I 1.39 14.75 10.60 HLA073 1 5687311556873184 ERV_0263370 ERVL-E-int I 1.00 3.86 3.86 HLA078 1 5696891856969527 ERV_0263455 MLT1H,MLT1H-int LI 0.00 1.99 300.00 HLA066 158221070 58221140 ERV_0264536 MER4-int I 0.00 1.63 300.00 HLA072 158221070 58221140 ERV_0264536 MER4-int I 0.00 1.64 300.00 HLA067 159785413 59787672 ERV_0265874 THE1B,THE1B-int LIL 0.18 3.70 20.36 HLA0691 59785413 59787672 ERV_0265874 THE1B,THE1B-int LIL 0.63 2.42 3.84HLA071 1 59785413 59787672 ERV_0265874 THE1B,THE1B-int LIL 1.02 2.602.54 HLA072 1 59785413 59787672 ERV_0265874 THE1B,THE1B-int LIL 0.352.18 6.30 HLA073 1 59785413 59787672 ERV_0265874 THE1B,THE1B-int LIL0.62 1.68 2.69 HLA053 1 59888378 59890653 ERV_0265938 THE1B,THE1B-intLIL 1.31 3.99 3.04 HLA063 1 61924481 61925948 ERV_0267469LTR37-int,LTR37B LI 51.40 112.17 2.18 HLA063 1 64974575 64976920ERV_0269958 ERV3-16A3_I-int,LTR16B1 LI 0.34 2.59 7.70 HLA067 1 6497457564976920 ERV_0269958 ERV3-16A3_I-int,LTR16B1 LI 1.16 2.52 2.19 HLA063 165581296 65582537 ERV_0270527 MLT1F2,MLT1F2-int LI 0.88 2.59 2.96 HLA0651 72636642 72636752 ERV_0274840 HERVIP10FH-int I 0.00 2.24 300.00 HLA0781 72636642 72636752 ERV_0274840 HERVIP10FH-int I 0.00 1.57 300.00 HLA0651 74725239 74727410 ERV_0275834 THE1B,THE1B-int LIL 1.29 7.58 5.87HLA076 1 74725239 74727410 ERV_0275834 THE1B,THE1B-int LIL 1.45 5.263.62 HLA078 1 74725239 74727410 ERV_0275834 THE1B,THE1B-int LIL 2.697.06 2.62 HLA053 1 74740033 74744894 ERV_0275843 HERV9N-int,LTR12,LTR12BLIL 0.84 2.22 2.64 HLA053 1 74741115 74744614 ERV_0275844 HERV9-int I0.84 2.22 2.64 HLA058 1 75296224 75297084 ERV_0276136 MLT1G,MLT1G-intLIL 0.19 4.43 23.07 HLA065 1 75296224 75297084 ERV_0276136MLT1G,MLT1G-int LIL 0.00 7.59 300.00 HLA065 1 77918963 77919582ERV_0277845 THE1A,THE1A-int LI 0.00 2.10 300.00 HLA072 1 7819343878194358 ERV_0278072 MSTD,MSTD-int LI 0.00 1.67 300.00 HLA058 1 7822509578225460 ERV_0278091 ERVL-E-int I 1.80 14.16 7.88 HLA067 1 7822509578225460 ERV_0278091 ERVL-E-int I 0.92 6.71 7.34 HLA058 1 7832427378326208 ERV_0278158 ERVL-E-int I 0.30 1.77 5.88 HLA065 1 7864641478648605 ERV_0278348 THE1C,THE1C-int LIL 0.51 2.50 4.86 HLA072 178646414 78648605 ERV_0278348 THE1C,THE1C-int LIL 1.39 2.90 2.09 HLA0531 86376510 86378854 ERV_0282458 THE1D,THE1D-int LIL 0.68 2.68 3.95HLA078 1 86692599 86694874 ERV_0282631 HUERS-P3b-int,LTR9B LI 0.00 6.19300.00 HLA058 1 87800644 87803070 ERV_0283324 ERVL-B4-int,MLT2C1 LI 0.365.56 15.33 HLA071 1 87800644 87803070 ERV_0283324 ERVL-B4-int,MLT2C1 LI0.38 1.56 4.10 HLA072 1 87800644 87803070 ERV_0283324 ERVL-B4-int,MLT2C1LI 0.00 1.66 300.00 HLA065 1 93261861 93264299 ERV_0286811THE1D,THE1D-int LIL 3.04 10.58 3.48 HLA078 1 93261861 93264299ERV_0286811 THE1D,THE1D-int LIL 5.01 10.11 2.02 HLA065 1 9326388693263973 ERV_0286812 THE1D-int I 3.04 10.58 3.48 HLA078 1 9326388693263973 ERV_0286812 THE1D-int I 5.01 10.11 2.02 HLA061 1 9338511893385630 ERV_0286902 MLT1J1,MLT1J1-int LI 0.00 2.49 300.00 HLA063 193385118 93385630 ERV_0286902 MLT1J1,MLT1J1-int LI 0.00 2.52 300.00HLA078 1 93385118 93385630 ERV_0286902 MLT1J1,MLT1J1-int LI 0.00 1.97300.00 HLA058 1 94161627 94167221 ERV_0287406 HERVL-int,MLT2A1 LIL 0.674.44 6.63 HLA069 1 94161627 94167221 ERV_0287406 HERVL-int,MLT2A1 LIL1.00 2.21 2.21 HLA078 1 94161627 94167221 ERV_0287406 HERVL-int,MLT2A1LIL 0.00 1.50 300.00 HLA082 1 94161627 94167221 ERV_0287406HERVL-int,MLT2A1 LIL 0.70 2.21 3.15 HLA058 1 94661344 94669497ERV_0287708 MER4-int,MER4C LIL 0.17 2.02 11.93 HLA058 1 9466640494666979 ERV_0287709 MER4B-int I 0.17 2.02 11.93 HLA058 1 9466711894669028 ERV_0287711 MER4-int I 0.17 2.02 11.93 HLA065 1 9525062295254066 ERV_0288131 ERVL-E-int I 0.69 1.91 2.76 HLA066 1 9525062295254066 ERV_0288131 ERVL-E-int I 0.55 1.95 3.54 HLA072 1 9525062295254066 ERV_0288131 ERVL-E-int I 0.63 1.67 2.64 HLA072 1 1E+08 1E+08ERV_0291157 THE1B,THE1B-int LI 0.00 2.01 300.00 HLA053 1 1.01E+081.01E+08 ERV_0291425 THE1D,THE1D-int LI 0.83 2.00 2.41 HLA076 1 1.01E+081.01E+08 ERV_0291425 THE1D,THE1D-int LI 0.73 1.85 2.52 HLA058 1 1.02E+081.02E+08 ERV_0292179 THE1B,THE1B-int LIL 0.00 4.85 300.00 HLA067 11.04E+08 1.04E+08 ERV_0292792 THE1B,THE1B-int LI 0.65 3.86 5.89 HLA058 11.04E+08 1.04E+08 ERV_0293028 THE1D,THE1D-int LI 1.58 12.96 8.21 HLA0781 1.04E+08 1.04E+08 ERV_0293205 HERVE_a-int I 0.04 4.82 131.07 HLA078 11.05E+08 1.05E+08 ERV_0293262 ERVL-E-int I 0.00 2.19 300.00 HLA058 11.06E+08 1.06E+08 ERV_0293695 LTR38B,MER83A-int LI 0.00 6.82 300.00HLA053 1 1.08E+08 1.08E+08 ERV_0294968 THE1A,THE1A-int LIL 0.14 1.7612.80 HLA061 1 1.13E+08 1.13E+08 ERV_0297844 MLT1B,MLT1B-int LI 0.731.92 2.64 HLA053 1 1.13E+08 1.13E+08 ERV_0298108 LTR54B,MER57A-int LI1.18 2.78 2.35 HLA076 1 1.13E+08 1.13E+08 ERV_0298108 LTR54B,MER57A-intLI 0.09 1.58 18.08 HLA053 1 1.13E+08 1.13E+08 ERV_0298109 HERV35I-int I1.18 2.78 2.35 HLA076 1 1.13E+08 1.13E+08 ERV_0298109 HERV35I-int I 0.091.58 18.08 HLA053 1 1.13E+08 1.13E+08 ERV_0298111 LTR49-int I 1.18 2.782.35 HLA076 1 1.13E+08 1.13E+08 ERV_0298111 LTR49-int I 0.09 1.58 18.08HLA067 1 1.13E+08 1.13E+08 ERV_0298181 MLT1A0,MLT1A0-int LI 0.17 3.1418.49 HLA058 1 1.14E+08 1.14E+08 ERV_0298689 THE1A,THE1A-int LIL 1.738.54 4.95 HLA072 1 1.14E+08 1.14E+08 ERV_0298689 THE1A,THE1A-int LIL1.74 4.59 2.63 HLA053 1 1.14E+08 1.14E+08 ERV_0298815 MLT1H-int I 0.282.47 8.71 HLA058 1 1.17E+08 1.17E+08 ERV_0300843 MamRep605,THE1B,THE1B-int LIL 0.15 2.64 17.92 HLA066 1 1.17E+08 1.17E+08 ERV_0300843MamRep605,THE1B,THE 1B-int LIL 0.83 2.30 2.76 HLA067 1 1.17E+08 1.17E+08ERV_0300843 MamRep605,THE1B,THE 1B-int LIL 2.34 4.95 2.12 HLA069 11.17E+08 1.17E+08 ERV_0300843 MamRep605,THE1B,THE 1B-int LIL 0.48 3.366.95 HLA071 1 1.17E+08 1.17E+08 ERV_0300843 MamRep605,THE1B,THE 1B-intLIL 1.21 4.91 4.05 HLA076 1 1.17E+08 1.17E+08 ERV_0300843MamRep605,THE1B,THE 1B-int LIL 1.69 16.42 9.75 HLA078 1 1.17E+081.17E+08 ERV_0300843 MamRep605,THE1B,THE 1B-int LIL 2.39 6.42 2.68HLA082 1 1.17E+08 1.17E+08 ERV_0300843 MamRep605,THE1B,THE 1B-int LIL1.83 6.30 3.45 HLA078 1 1.18E+08 1.18E+08 ERV_0301402 HERVL18-int,LTR18CLIL 0.00 1.74 300.00 HLA058 1 1.19E+08 1.19E+08 ERV_0302116HERV17-int,LTR17 LIL 0.71 2.16 3.06 HLA053 1 1.19E+08 1.19E+08ERV_0302235 MER4-int,MER4A1 LIL 0.41 5.40 13.10 HLA069 1 1.19E+081.19E+08 ERV_0302235 MER4-int,MER4A1 LIL 3.66 10.18 2.78 HLA053 11.19E+08 1.19E+08 ERV_0302237 MER4-int I 0.41 5.40 13.10 HLA069 11.19E+08 1.19E+08 ERV_0302237 MER4-int I 3.66 10.18 2.78 HLA053 11.19E+08 1.19E+08 ERV_0302249 THE1A,THE1A-int LI 0.38 4.30 11.25 HLA0671 1.19E+08 1.19E+08 ERV_0302249 THE1A,THE1A-int LI 1.60 3.26 2.04 HLA0691 1.19E+08 1.19E+08 ERV_0302249 THE1A,THE1A-int LI 1.93 6.29 3.26 HLA0691 1.19E+08 1.19E+08 ERV_0302257 THE1B,THE1B-int LIL 0.66 1.56 2.36HLA066 1 1.19E+08 1.19E+08 ERV_0302300 HUERS-P2-int,LTR1A2 LI 0.00 4.94300.00 HLA067 1 1.2E+08 1.2E+08 ERV_0302873 MLT1E3,MLT1E3-int LI 3.119.30 2.99 HLA078 1 1.2E+08 1.2E+08 ERV_0302873 MLT1E3,MLT1E3-int LI 2.819.46 3.37 HLA058 1 1.21E+08 1.21E+08 ERV_0303126 ERVL-E-int,LTR33 LI1.07 3.33 3.10 HLA072 1 1.21E+08 1.21E+08 ERV_0303126 ERVL-E-int,LTR33LI 0.46 1.74 3.77 HLA058 1 1.21E+08 1.21E+08 ERV_0303136HERVP71A-int,LTR71B LI 1.07 3.33 3.10 HLA072 1 1.21E+08 1.21E+08ERV_0303136 HERVP71A-int,LTR71B LI 0.46 1.74 3.77 HLA065 1 1.44E+081.44E+08 ERV_0304455 ERVL-E-int,LTR33 LI 2.24 17.56 7.86 HLA067 11.44E+08 1.44E+08 ERV_0304455 ERVL-E-int,LTR33 LI 12.97 62.53 4.82HLA069 1 1.44E+08 1.44E+08 ERV_0304455 ERVL-E-int,LTR33 LI 2.75 8.603.13 HLA078 1 1.44E+08 1.44E+08 ERV_0304455 ERVL-E-int,LTR33 LI 3.5827.68 7.74 HLA072 1 1.45E+08 1.45E+08 ERV_0304537 LTR23-int,LTR56 LI0.08 2.41 31.64 HLA078 1 1.45E+08 1.45E+08 ERV_0304537 LTR23-int,LTR56LI 0.05 3.82 81.84 HLA072 1 1.45E+08 1.45E+08 ERV_0304539 LTR39-int I0.08 2.41 31.64 HLA078 1 1.45E+08 1.45E+08 ERV_0304539 LTR39-int I 0.053.82 81.84 HLA053 1 1.45E+08 1.45E+08 ERV_0305070 MER70-int I 0.00 1.82300.00 HLA053 1 1.47E+08 1.47E+08 ERV_0306095 MLT1E2,MLT1E2-int LI 2.056.38 3.11 HLA065 1 1.47E+08 1.47E+08 ERV_0306095 MLT1E2,MLT1E2-int LI1.12 5.57 4.96 HLA076 1 1.47E+08 1.47E+08 ERV_0306095 MLT1E2,MLT1E2-intLI 2.81 8.40 2.99 HLA078 1 1.47E+08 1.47E+08 ERV_0306095MLT1E2,MLT1E2-int LI 0.85 5.31 6.26 HLA063 1 1.48E+08 1.48E+08ERV_0306827 ERVL-E-int,LTR33 LI 4.55 11.28 2.48 HLA067 1 1.48E+081.48E+08 ERV_0306827 ERVL-E-int,LTR33 LI 7.54 16.68 2.21 HLA069 11.48E+08 1.48E+08 ERV_0306827 ERVL-E-int,LTR33 LI 0.55 3.37 6.10 HLA0761 1.48E+08 1.48E+08 ERV_0306827 ERVL-E-int,LTR33 LI 6.99 15.52 2.22HLA078 1 1.48E+08 1.48E+08 ERV_0306827 ERVL-E-int,LTR33 LI 0.95 16.7017.56 HLA078 1 1.48E+08 1.48E+08 ERV_0306937 Harlequin-int,LTR2B LI 0.005.42 300.00 HLA078 1 1.48E+08 1.48E+08 ERV_0306938 HERVE_a-int I 0.005.42 300.00 HLA058 1 1.48E+08 1.48E+08 ERV_0306999 ERVL-E-int,LTR33 LI0.67 2.45 3.67 HLA072 1 1.48E+08 1.48E+08 ERV_0306999 ERVL-E-int,LTR33LI 0.47 3.58 7.60 HLA058 1 1.48E+08 1.48E+08 ERV_0307009HERVP71A-int,LTR71B LI 0.67 2.45 3.67 HLA072 1 1.48E+08 1.48E+08ERV_0307009 HERVP71A-int,LTR71B LI 0.47 3.58 7.60 HLA058 1 1.48E+081.48E+08 ERV_0307027 MER4-int,MER4C LI 13.14 28.66 2.18 HLA063 11.48E+08 1.48E+08 ERV_0307027 MER4-int,MER4C LI 1.62 3.34 2.06 HLA065 11.48E+08 1.48E+08 ERV_0307027 MER4-int,MER4C LI 4.62 15.67 3.39 HLA072 11.48E+08 1.48E+08 ERV_0307027 MER4-int,MER4C LI 2.56 17.99 7.03 HLA078 11.48E+08 1.48E+08 ERV_0307027 MER4-int,MER4C LI 0.29 2.16 7.42 HLA058 11.48E+08 1.48E+08 ERV_0307046 MER66-int,MER66C LI 9.99 35.80 3.58 HLA0671 1.48E+08 1.48E+08 ERV_0307046 MER66-int,MER66C LI 8.19 17.08 2.09HLA069 1 1.48E+08 1.48E+08 ERV_0307046 MER66-int,MER66C LI 4.45 11.202.52 HLA072 1 1.48E+08 1.48E+08 ERV_0307046 MER66-int,MER66C LI 8.4720.58 2.43 HLA073 1 1.48E+08 1.48E+08 ERV_0307046 MER66-int,MER66C LI3.69 11.09 3.01 HLA078 1 1.48E+08 1.48E+08 ERV_0307046 MER66-int,MER66CLI 6.45 25.53 3.96 HLA065 1 1.49E+08 1.49E+08 ERV_0307444ERVL-E-int,LTR33 LI 1.33 7.63 5.74 HLA067 1 1.49E+08 1.49E+08ERV_0307444 ERVL-E-int,LTR33 LI 4.37 14.85 3.40 HLA078 1 1.49E+081.49E+08 ERV_0307444 ERVL-E-int,LTR33 LI 1.95 14.77 7.59 HLA058 11.49E+08 1.49E+08 ERV_0307509 PRIMA4-int I 0.65 2.38 3.65 HLA067 11.49E+08 1.49E+08 ERV_0307509 PRIMA4-int I 0.29 2.23 7.59 HLA067 11.49E+08 1.49E+08 ERV_0307511 ERV24_Prim-int I 0.00 1.53 300.00 HLA063 11.5E+08 1.5E+08 ERV_0307746 ERVL-E-int,LTR33 LI 0.76 1.97 2.58 HLA071 11.5E+08 1.5E+08 ERV_0307746 ERVL-E-int,LTR33 LI 1.03 3.27 3.17 HLA072 11.5E+08 1.5E+08 ERV_0307746 ERVL-E-int,LTR33 LI 0.33 1.60 4.85 HLA073 11.5E+08 1.5E+08 ERV_0307746 ERVL-E-int,LTR33 LI 1.65 3.65 2.21 HLA063 11.5E+08 1.5E+08 ERV_0307756 HERVP71A-int,LTR71B LI 0.76 1.97 2.58 HLA0711 1.5E+08 1.5E+08 ERV_0307756 HERVP71A-int,LTR71B LI 1.03 3.27 3.17HLA072 1 1.5E+08 1.5E+08 ERV_0307756 HERVP71A-int,LTR71B LI 0.33 1.604.85 HLA073 1 1.5E+08 1.5E+08 ERV_0307756 HERVP71A-int,LTR71B LI 1.653.65 2.21 HLA058 1 1.5E+08 1.5E+08 ERV_0307804 MER66-int,MER66C LI 0.082.35 27.84 HLA065 1 1.5E+08 1.5E+08 ERV_0307804 MER66-int,MER66C LI 0.883.26 3.71 HLA069 1 1.5E+08 1.5E+08 ERV_0307804 MER66-int,MER66C LI 0.001.73 300.00 HLA071 1 1.5E+08 1.5E+08 ERV_0307804 MER66-int,MER66C LI0.84 3.16 3.76 HLA072 1 1.5E+08 1.5E+08 ERV_0307804 MER66-int,MER66C LI0.68 3.21 4.70 HLA058 1 1.51E+08 1.51E+08 ERV_0308616 HERVK-int I 0.745.88 7.93 HLA061 1 1.51E+08 1.51E+08 ERV_0308616 HERVK-int I 3.54 8.322.35 HLA063 1 1.51E+08 1.51E+08 ERV_0308616 HERVK-int I 1.78 4.32 2.42HLA066 1 1.51E+08 1.51E+08 ERV_0308616 HERVK-int I 0.79 4.08 5.18 HLA0671 1.51E+08 1.51E+08 ERV_0308616 HERVK-int I 2.19 5.76 2.63 HLA069 11.51E+08 1.51E+08 ERV_0308616 HERVK-int I 1.11 2.71 2.43 HLA073 11.51E+08 1.51E+08 ERV_0308616 HERVK-int I 1.45 3.46 2.38 HLA078 11.51E+08 1.51E+08 ERV_0308616 HERVK-int I 0.66 13.60 20.63 HLA065 11.51E+08 1.51E+08 ERV_0308973 MER41-int,MER41A LI 0.21 4.20 20.13 HLA0721 1.51E+08 1.51E+08 ERV_0308973 MER41-int,MER41A LI 0.76 1.78 2.35HLA078 1 1.51E+08 1.51E+08 ERV_0308973 MER41-int,MER41A LI 0.34 2.015.95 HLA058 1 1.51E+08 1.51E+08 ERV_0309149 MLT1F2,MLT1F2-int LIL 1.013.30 3.25 HLA063 1 1.51E+08 1.51E+08 ERV_0309149 MLT1F2,MLT1F2-int LIL1.83 3.94 2.16 HLA065 1 1.51E+08 1.51E+08 ERV_0309149 MLT1F2,MLT1F2-intLIL 1.22 5.69 4.66 HLA067 1 1.51E+08 1.51E+08 ERV_0309149MLT1F2,MLT1F2-int LIL 0.44 2.43 5.47 HLA078 1 1.51E+08 1.51E+08ERV_0309149 MLT1F2,MLT1F2-int LIL 0.89 4.08 4.58 HLA058 1 1.52E+081.52E+08 ERV_0309763 HUERS-P1-int,LTR8 LI 0.00 2.42 300.00 HLA058 11.52E+08 1.52E+08 ERV_0309765 HERV35I-int I 0.00 2.49 300.00 HLA058 11.52E+08 1.52E+08 ERV_0309775 LTR54,MER57A-int LI 0.00 2.10 300.00HLA063 1 1.56E+08 1.56E+08 ERV_0312442 LTR25-int I 1.17 2.44 2.09 HLA0651 1.56E+08 1.56E+08 ERV_0312442 LTR25-int I 0.46 1.64 3.53 HLA072 11.56E+08 1.56E+08 ERV_0312442 LTR25-int I 0.23 3.83 16.90 HLA078 11.56E+08 1.56E+08 ERV_0312442 LTR25-int I 0.00 1.82 300.00 HLA058 11.56E+08 1.56E+08 ERV_0312445 HERV17-int I 1.68 9.49 5.66 HLA061 11.56E+08 1.56E+08 ERV_0312445 HERV17-int I 1.26 4.45 3.52 HLA063 11.56E+08 1.56E+08 ERV_0312445 HERV17-int I 1.79 6.51 3.64 HLA067 11.56E+08 1.56E+08 ERV_0312445 HERV17-int I 1.83 12.53 6.83 HLA069 11.56E+08 1.56E+08 ERV_0312445 HERV17-int I 1.14 3.30 2.91 HLA073 11.56E+08 1.56E+08 ERV_0312445 HERV17-int I 0.97 8.75 9.02 HLA078 11.56E+08 1.56E+08 ERV_0312445 HERV17-int I 1.14 48.52 42.39 HLA082 11.56E+08 1.56E+08 ERV_0312445 HERV17-int I 0.94 4.06 4.34 HLA058 11.56E+08 1.56E+08 ERV_0312447 HERVK-int, LTR5_Hs LIL 1.68 9.49 5.66HLA061 1 1.56E+08 1.56E+08 ERV_0312447 HERVK-int, LTR5_Hs LIL 1.26 4.453.52 HLA063 1 1.56E+08 1.56E+08 ERV_0312447 HERVK-int, LTR5_Hs LIL 1.796.51 3.64 HLA067 1 1.56E+08 1.56E+08 ERV_0312447 HERVK-int, LTR5_Hs LIL1.83 12.53 6.83 HLA069 1 1.56E+08 1.56E+08 ERV_0312447 HERVK-int,LTR5_Hs LIL 1.14 3.30 2.91 HLA073 1 1.56E+08 1.56E+08 ERV_0312447HERVK-int, LTR5_Hs LIL 0.97 8.75 9.02 HLA078 1 1.56E+08 1.56E+08ERV_0312447 HERVK-int, LTR5_Hs LIL 1.14 48.52 42.39 HLA082 1 1.56E+081.56E+08 ERV_0312447 HERVK-int, LTR5_Hs LIL 0.94 4.06 4.34 HLA078 11.56E+08 1.56E+08 ERV_0312452 LTR25,LTR25-int LI 0.04 2.10 58.00 HLA0631 1.56E+08 1.56E+08 ERV_0312458 HERV4_I-int,MER51A LIL 0.77 1.70 2.22HLA073 1 1.56E+08 1.56E+08 ERV_0312458 HERV4_I-int,MER51A LIL 0.72 1.712.38 HLA078 1 1.56E+08 1.56E+08 ERV_0312458 HERV4_I-int,MER51A LIL 0.685.22 7.68 HLA063 1 1.56E+08 1.56E+08 ERV_0312459 HERV4_I-int I 0.77 1.702.22 HLA073 1 1.56E+08 1.56E+08 ERV_0312459 HERV4_I-int I 0.72 1.71 2.38HLA078 1 1.56E+08 1.56E+08 ERV_0312459 HERV4_I-int I 0.68 5.22 7.68HLA058 1 1.56E+08 1.56E+08 ERV_0312929 HERVK22-int,LTR22E LIL 2.85 10.823.79 HLA058 1 1.56E+08 1.56E+08 ERV_0312931 HERVK22-int I 2.85 10.823.79 HLA063 1 1.57E+08 1.57E+08 ERV_0313303 ERVL-E-int I 0.00 5.19300.00 HLA067 1 1.57E+08 1.57E+08 ERV_0313303 ERVL-E-int I 0.00 2.61300.00 HLA058 1 1.57E+08 1.57E+08 ERV_0313742 HERVFH21-int,LTR21A LIL0.00 2.54 300.00 HLA078 1 1.57E+08 1.57E+08 ERV_0313742HERVFH21-int,LTR21A LIL 0.00 2.84 300.00 HLA058 1 1.57E+08 1.57E+08ERV_0313743 HERVFH21-int I 0.00 2.54 300.00 HLA078 1 1.57E+08 1.57E+08ERV_0313743 HERVFH21-int I 0.00 2.84 300.00 HLA071 1 1.57E+08 1.57E+08ERV_0313831 THE1C,THE1C-int LIL 0.59 2.03 3.45 HLA053 1 1.58E+081.58E+08 ERV_0314035 ERVL-B4-int,MLT2B1 LI 1.06 3.79 3.57 HLA069 11.58E+08 1.58E+08 ERV_0314035 ERVL-B4-int,MLT2B1 LI 1.10 2.96 2.70HLA073 1 1.58E+08 1.58E+08 ERV_0314035 ERVL-B4-int,MLT2B1 LI 0.82 2.062.50 HLA069 1 1.58E+08 1.58E+08 ERV_0314274 LTR23-int I 0.28 1.99 7.05HLA063 1 1.6E+08 1.6E+08 ERV_0315340 ERVL-E-int I 2.97 7.04 2.37 HLA0671 1.6E+08 1.6E+08 ERV_0315340 ERVL-E-int I 2.91 6.72 2.31 HLA069 11.6E+08 1.6E+08 ERV_0315340 ERVL-E-int I 1.99 5.71 2.87 HLA076 1 1.6E+081.6E+08 ERV_0315340 ERVL-E-int I 1.90 4.95 2.61 HLA078 1 1.6E+08 1.6E+08ERV_0315340 ERVL-E-int I 1.36 3.71 2.73 HLA067 1 1.61E+08 1.61E+08ERV_0316155 HERVL-int,MLT2Al LIL 0.40 1.76 4.37 HLA058 1 1.68E+081.68E+08 ERV_0320772 MLT1J1,MLT1J1-int LI 3.83 14.74 3.85 HLA072 11.68E+08 1.68E+08 ERV_0320772 MLT1J1,MLT1J1-int LI 1.59 16.75 10.51HLA078 1 1.68E+08 1.68E+08 ERV_0320772 MLT1J1,MLT1J1-int LI 0.00 4.84300.00 HLA058 1 1.69E+08 1.69E+08 ERV_0321295 PABL_A,PABL_A-int LI 1.042.71 2.61 HLA065 1 1.69E+08 1.69E+08 ERV_0321295 PABL_A,PABL_A-int LI0.23 4.65 19.99 HLA067 1 1.69E+08 1.69E+08 ERV_0321295 PABL_A,PABL_A-intLI 2.39 5.14 2.15 HLA073 1 1.69E+08 1.69E+08 ERV_0321295PABL_A,PABL_A-int LI 0.81 3.95 4.85 HLA061 1 1.71E+08 1.71E+08ERV_0322179 MLTIJ-int I 0.00 2.55 300.00 HLA078 1 1.73E+08 1.73E+08ERV_0323303 MER101-int I 0.01 1.75 158.70 HLA078 1 1.73E+08 1.73E+08ERV_0323304 MER101-int I 0.01 1.75 158.70 HLA066 1 1.73E+08 1.73E+08ERV_0323669 ERVL-E-int I 0.30 1.98 6.48 HLA058 1 1.74E+08 1.74E+08ERV_0323754 MLT1G1,MLT1G1-int LI 0.00 3.92 300.00 HLA058 1 1.74E+081.74E+08 ERV_0323793 MER4-int,MER4A1 LIL 0.01 2.68 279.20 HLA058 11.74E+08 1.74E+08 ERV_0323794 MER4-int I 0.01 2.68 279.20 HLA058 11.74E+08 1.74E+08 ERV_0323795 HERVIP10FH-int,LTR10F LIL 0.01 2.68 279.20HLA058 1 1.74E+08 1.74E+08 ERV_0323796 HERVIP10F-int I 0.01 2.68 279.20HLA053 1 1.74E+08 1.74E+08 ERV_0324280 MER61-int I 1.53 4.95 3.23 HLA0671 1.74E+08 1.74E+08 ERV_0324280 MER61-int I 0.00 4.94 300.00 HLA072 11.74E+08 1.74E+08 ERV_0324280 MER61-int I 0.00 3.30 300.00 HLA058 11.75E+08 1.75E+08 ERV_0324822 HERV9NC-int,LTR12C LIL 0.05 1.71 32.29HLA069 1 1.75E+08 1.75E+08 ERV_0324822 HERV9NC-int,LTR12C LIL 0.00 2.79300.00 HLA076 1 1.75E+08 1.75E+08 ERV_0324822 HERV9NC-int,LTR12C LIL0.04 19.36 512.72 HLA078 1 1.75E+08 1.75E+08 ERV_0324822HERV9NC-int,LTR12C LIL 0.10 2.42 23.11 HLA082 1 1.75E+08 1.75E+08ERV_0324822 HERV9NC-int,LTR12C LIL 0.00 1.74 300.00 HLA078 1 1.76E+081.76E+08 ERV_0325479 MLT1L,MLT1L-int LI 0.00 1.70 300.00 HLA061 11.79E+08 1.79E+08 ERV_0326846 HERVK9-int,MER9a2 LIL 0.67 5.09 7.64HLA061 1 1.82E+08 1.82E+08 ERV_0329344 MER61-int,MER61B LIL 1.42 4.653.26 HLA066 1 1.82E+08 1.82E+08 ERV_0329344 MER61-int,MER61B LIL 0.091.79 19.78 HLA069 1 1.82E+08 1.82E+08 ERV_0329344 MER61-int,MER61B LIL0.26 6.78 26.57 HLA071 1 1.82E+08 1.82E+08 ERV_0329344 MER61-int,MER61BLIL 0.09 2.12 22.86 HLA073 1 1.82E+08 1.82E+08 ERV_0329344MER61-int,MER61B LIL 0.13 13.08 101.36 HLA076 1 1.82E+08 1.82E+08ERV_0329344 MER61-int,MER61B LIL 0.63 10.76 17.01 HLA078 1 1.82E+081.82E+08 ERV_0329344 MER61-int,MER61B LIL 0.05 2.69 56.38 HLA067 11.82E+08 1.82E+08 ERV_0329491 ERV3-16A3_I-int I 0.00 1.98 300.00 HLA0581 1.91E+08 1.91E+08 ERV_0334734 MLT1J2-int I 0.00 2.39 300.00 HLA058 11.91E+08 1.91E+08 ERV_0334837 MLT1J1,MLT1J1-int LI 0.50 2.06 4.13 HLA0631 1.93E+08 1.93E+08 ERV_0335925 ERV3-16A3_I-int I 0.00 2.00 300.00HLA065 1 1.94E+08 1.94E+08 ERV_0336177 MLT1J1,MLT1J1-int LI 0.00 1.80300.00 HLA065 1 1.97E+08 1.97E+08 ERV_0337453 THE1C,THE1C-int LIL 1.214.72 3.91 HLA067 1 1.97E+08 1.97E+08 ERV_0337453 THE1C,THE1C-int LIL4.37 26.56 6.08 HLA069 1 1.97E+08 1.97E+08 ERV_0337453 THE1C,THE1C-intLIL 1.71 8.65 5.06 HLA082 1 1.97E+08 1.97E+08 ERV_0337453THE1C,THE1C-int LIL 2.23 13.83 6.21 HLA067 1 1.97E+08 1.97E+08ERV_0337544 THE1D,THE1D-int LI 1.50 32.87 21.89 HLA069 1 1.97E+081.97E+08 ERV_0337544 THE1D,THE1D-int LI 0.29 2.74 9.53 HLA058 1 1.98E+081.98E+08 ERV_0338100 LTR37-int I 0.00 4.48 300.00 HLA072 1 2.02E+082.02E+08 ERV_0340485 MER21-int,MER21B,MER21C LIL 0.26 1.96 7.60 HLA067 12.04E+08 2.04E+08 ERV_0342071 MLT1C,MLT1C-int LI 0.43 1.85 4.30 HLA063 12.04E+08 2.04E+08 ERV_0342381 MLTIAO,MLTIAO-int LI 2.86 6.08 2.12 HLA0651 2.04E+08 2.04E+08 ERV_0342381 MLTIAO,MLTIAO-int LI 0.22 1.96 8.83HLA067 1 2.04E+08 2.04E+08 ERV_0342381 MLTIAO,MLTIAO-int LI 1.60 5.453.41 HLA069 1 2.04E+08 2.04E+08 ERV_0342381 MLTIAO,MLTIAO-int LI 0.295.68 19.33 HLA078 1 2.04E+08 2.04E+08 ERV_0342381 MLTIAO,MLTIAO-int LI0.73 2.39 3.29 HLA053 1 2.06E+08 2.06E+08 ERV_0343733 HERV17-int,LTR17LI 0.01 2.28 240, 50 HLA053 1 2.06E+08 2.06E+08 ERV_0343741HERVH-int,LTR7B LIL 0.00 5.85 300.00 HLA065 1 2.06E+08 2.06E+08ERV_0343741 HERVH-int,LTR7B LIL 0.19 2.20 11.86 HLA067 1 2.06E+082.06E+08 ERV_0343741 HERVH-int,LTR7B LIL 0.85 6.07 7.11 HLA072 12.06E+08 2.06E+08 ERV_0343741 HERVH-int,LTR7B LIL 0.75 2.31 3.08 HLA0781 2.06E+08 2.06E+08 ERV_0343741 HERVH-int,LTR7B LIL 0.26 1.83 7.11HLA063 1 2.07E+08 2.07E+08 ERV_0344612 ERVL-E-int,MLT2F LI 5.07 11.122.19 HLA065 1 2.07E+08 2.07E+08 ERV_0344612 ERVL-E-int,MLT2F LI 0.142.36 16.50 HLA067 1 2.07E+08 2.07E+08 ERV_0344612 ERVL-E-int,MLT2F LI1.00 7.02 7.00 HLA082 1 2.07E+08 2.07E+08 ERV_0344612 ERVL-E-int,MLT2FLI 2.35 6.06 2.58 HLA065 1 2.07E+08 2.07E+08 ERV_0344622 ERV3-16A3_I-intI 0.99 6.12 6.18 HLA067 1 2.07E+08 2.07E+08 ERV_0344622 ERV3-16A3_I-intI 11.19 67.16 6.00 HLA069 1 2.07E+08 2.07E+08 ERV_0344622ERV3-16A3_I-int I 4.07 39.39 9.68 HLA078 1 2.1E+08 2.1E+08 ERV_0346194THE1A,THE1A-int LIL 0.00 3.32 300.00 HLA078 1 2.11E+08 2.11E+08ERV_0347136 MSTA,MSTA-int LIL 0.00 9.56 300.00 HLA067 1 2.14E+082.14E+08 ERV_0349196 MLT1J2,MLT1J2-int LIL 1.40 6.16 4.39 HLA078 12.14E+08 2.14E+08 ERV_0349196 MLT1J2,MLT1J2-int LIL 0.46 2.35 5.11HLA053 1 2.16E+08 2.16E+08 ERV_0350182 MER41-int,MER41B LIL 1.41 5.033.57 HLA063 1 2.16E+08 2.16E+08 ERV_0350182 MER41-int,MER41B LIL 1.503.23 2.15 HLA067 1 2.16E+08 2.16E+08 ERV_0350182 MER41-int,MER41B LIL0.57 4.90 8.64 HLA078 1 2.19E+08 2.19E+08 ERV_0351862 HERVE_a-int I 0.002.34 300.00 HLA078 1 2.2E+08 2.2E+08 ERV_0352559 LTR49-int I 0.00 1.50300.00 HLA078 1 2.22E+08 2.22E+08 ERV_0353869 THE1B,THE1B-int LIL 0.009.01 300.00 HLA078 1 2.25E+08 2.25E+08 ERV_0355579 ERVL-E-int,LTR33 LI0.00 1.55 300.00 HLA061 1 2.26E+08 2.26E+08 ERV_0356351HERVK14-int,LTR14B LIL 0.00 2.10 300.00 HLA061 1 2.26E+08 2.26E+08ERV_0356599 ERVL-E-int I 0.44 3.12 7.15 HLA069 1 2.26E+08 2.26E+08ERV_0356599 ERVL-E-int I 0.38 2.12 5.56 HLA078 1 2.26E+08 2.26E+08ERV_0356599 ERVL-E-int I 0.64 7.24 11.39 HLA053 1 2.26E+08 2.26E+08ERV_0356859 ERVL-E-int I 0.33 2.34 7.16 HLA078 1 2.26E+08 2.26E+08ERV_0356859 ERVL-E-int I 0.00 1.93 300.00 HLA058 1 2.27E+08 2.27E+08ERV_0356997 HERVL66-int,LTR66 LIL 0.78 13.69 17.66 HLA066 1 2.27E+082.27E+08 ERV_0356997 HERVL66-int,LTR66 LIL 0.70 3.15 4.53 HLA076 12.27E+08 2.27E+08 ERV_0356997 HERVL66-int,LTR66 LIL 0.68 2.32 3.43HLA078 1 2.27E+08 2.27E+08 ERV_0356997 HERVL66-int,LTR66 LIL 0.09 165.431833.43 HLA065 1 2.28E+08 2.28E+08 ERV_0357676 ERVL-B4-int I 0.00 1.61300.00 HLA061 1 2.28E+08 2.28E+08 ERV_0357899 M ER57-int,MER57 A1 LIL0.00 2.12 300.00 HLA078 1 2.28E+08 2.28E+08 ERV_0357899 M ER57-int,MER57A1 LIL 0.05 3.21 58.34 HLA082 1 2.28E+08 2.28E+08 ERV_0357899 MER57-int,MER57 A1 LIL 0.24 2.18 9.26 HLA061 1 2.28E+08 2.28E+08ERV_0357902 MER57-int I 0.00 2.12 300.00 HLA078 1 2.28E+08 2.28E+08ERV_0357902 MER57-int I 0.05 3.21 58.34 HLA082 1 2.28E+08 2.28E+08ERV_0357902 MER57-int I 0.24 2.18 9.26 HLA061 1 2.28E+08 2.28E+08ERV_0357903 MER57-int I 0.00 2.12 300.00 HLA078 1 2.28E+08 2.28E+08ERV_0357903 MER57-int I 0.05 3.21 58.34 HLA082 1 2.28E+08 2.28E+08ERV_0357903 MER57-int I 0.24 2.18 9.26 HLA078 1 2.28E+08 2.28E+08ERV_0358009 MLT1B,MLT1B-int LIL 0.62 2.19 3.55 HLA078 1 2.28E+082.28E+08 ERV_0358012 MLT1B-int I 0.62 2.19 3.55 HLA078 1 2.32E+082.32E+08 ERV_0360392 HERVH-int,LTR7 LIL 0.05 1.53 32.91 HLA066 12.35E+08 2.35E+08 ERV_0362511 ERVL-E-int I 0.00 1.80 300.00 HLA053 12.38E+08 2.38E+08 ERV_0364789 MER61-int,MER61A LIL 0.28 2.56 9.25 HLA0581 2.38E+08 2.38E+08 ERV_0364789 MER61-int,MER61A LIL 0.00 4.36 300.00HLA069 1 2.38E+08 2.38E+08 ERV_0364789 MER61-int,MER61A LIL 0.70 1.802.55 HLA071 1 2.38E+08 2.38E+08 ERV_0364789 MER61-int,MER61A LIL 0.636.93 11.08 HLA072 1 2.38E+08 2.38E+08 ERV_0364789 MER61-int,MER61A LIL0.06 2.83 47.22 HLA078 1 2.38E+08 2.38E+08 ERV_0364789 MER61-int,MER61ALIL 0.05 13.05 253.17 HLA072 1 2.44E+08 2.44E+08 ERV_0368467 HERV16-intI 0.00 2.37 300.00 HLA082 1 2.44E+08 2.44E+08 ERV_0368467 HERV16-int I0.00 1.70 300.00 HLA053 1 2.46E+08 2.46E+08 ERV_0369651 THE1D-int I 0.008.24 300.00 HLA071 1 2.46E+08 2.46E+08 ERV_0369651 THE1D-int I 0.64 5.829.08 HLA073 1 2.46E+08 2.46E+08 ERV_0369651 THE1D-int I 0.00 4.84 300.00HLA076 1 2.46E+08 2.46E+08 ERV_0369651 THE1D-int I 0.00 2.23 300.00HLA078 1 2.46E+08 2.46E+08 ERV_0369651 THE1D-int I 0.00 8.80 300.00HLA082 1 2.46E+08 2.46E+08 ERV_0369651 THE1D-int I 0.00 2.06 300.00HLA053 1 2.46E+08 2.46E+08 ERV_0369652 THE1-int I 0.00 8.24 300.00HLA071 1 2.46E+08 2.46E+08 ERV_0369652 THE1-int I 0.64 5.82 9.08 HLA0731 2.46E+08 2.46E+08 ERV_0369652 THE1-int I 0.00 4.84 300.00 HLA076 12.46E+08 2.46E+08 ERV_0369652 THE1-int I 0.00 2.23 300.00 HLA078 12.46E+08 2.46E+08 ERV_0369652 THE1-int I 0.00 8.80 300.00 HLA082 12.46E+08 2.46E+08 ERV_0369652 THE1-int I 0.00 2.06 300.00 HLA063 12.47E+08 2.47E+08 ERV_0370122 HERVH48-int,MER48 LIL 0.57 1.67 2.91HLA067 1 2.47E+08 2.47E+08 ERV_0370122 HERVH48-int,MER48 LIL 0.26 1.897.36 HLA071 1 2.47E+08 2.47E+08 ERV_0370122 HERVH48-int,MER48 LIL 1.478.92 6.07 HLA073 1 2.47E+08 2.47E+08 ERV_0370122 HERVH48-int,MER48 LIL1.01 2.42 2.40 HLA078 1 2.47E+08 2.47E+08 ERV_0370434 HERVL74-int I 0.282.38 8.62 HLA072 1 2.47E+08 2.47E+08 ERV_0370442 THE1-int I 0.00 2.96300.00 HLA078 1 2.47E+08 2.47E+08 ERV_0370442 THE1-int I 0.00 2.85300.00 HLA058 1 2.47E+08 2.47E+08 ERV_0370443 THE1D,THE1D-int LI 0.372.14 5.76 HLA072 1 2.47E+08 2.47E+08 ERV_0370443 THE1D,THE1D-int LI 1.082.47 2.28 HLA061 1 2.47E+08 2.47E+08 ERV_0370478 MER4-int,MER4A1 LI 0.009.24 300.00 HLA065 1 2.47E+08 2.47E+08 ERV_0370478 MER4-int,MER4A1 LI0.11 2.20 19.39 HLA071 1 2.47E+08 2.47E+08 ERV_0370478 MER4-int,MER4A1LI 0.00 3.13 300.00 HLA078 1 2.47E+08 2.47E+08 ERV_0370478MER4-int,MER4A1 LI 0.00 3.31 300.00 HLA058 1 2.47E+08 2.47E+08ERV_0370499 HERVL40-int I 1.11 2.72 2.45 HLA061 1 2.47E+08 2.47E+08ERV_0370499 HERVL40-int I 0.58 1.78 3.08 HLA065 1 2.47E+08 2.47E+08ERV_0370499 HERVL40-int I 0.72 1.94 2.70 HLA072 1 2.47E+08 2.47E+08ERV_0370499 HERVL40-int I 0.50 5.82 11.68 HLA078 1 2.47E+08 2.47E+08ERV_0370499 HERVL40-int I 0.28 1.64 5.85 HLA069 1 2.47E+08 2.47E+08ERV_0370587 MLT1A0,MLT1A0-int LIL 1.16 3.36 2.90 HLA072 1 2.47E+082.47E+08 ERV_0370587 MLT1A0,MLT1A0-int LIL 1.16 2.42 2.08 HLA058 12.48E+08 2.48E+08 ERV_0371226 MLT1-int I 0.00 2.08 300.00 HLA053 12.49E+08 2.49E+08 ERV_0371328 MER51-int,MER51B LI 0.07 4.87 71.23 HLA0691 2.49E+08 2.49E+08 ERV_0371328 MER51-int,MER51B LI 0.00 6.89 300.00HLA071 1 2.49E+08 2.49E+08 ERV_0371328 MER51-int,MER51B LI 0.33 7.8823.65 HLA073 1 2.49E+08 2.49E+08 ERV_0371328 MER51-int,MER51B LI 0.002.28 300.00 HLA078 1 2.49E+08 2.49E+08 ERV_0371328 MER51-int,MER51B LI0.00 2.68 300.00 HLA063 10 918054 918164 ERV_0372088 LTR23-int I 0.502.00 4.00 HLA072 10 17216275 17216354 ERV_0387018 HERVIP10FH-int I 1.844.00 2.18 HLA067 10 17438986 17439047 ERV_0387265 LTR57-int I 0.00 3.00300.00 HLA073 10 17439777 17439884 ERV_0387266 LTR52-int I 0.00 2.00300.00 HLA067 10 1.3E+08 1.3E+08 ERV_0487502 MLT1L,MLT1L-int LI 1.203.25 2.70 HLA078 10 13650718 13650760 ERV_0497851 HERVL-int I 1.00 2.002.00 HLA067 10 45460134 45460194 ERV_0516568 MamGyp-int I 0.00 2.67300.00 HLA082 10 45460134 45460194 ERV_0516568 MamGyp-int I 0.00 2.00300.00 HLA078 10 48416034 48416181 ERV_0518349 ERVL-E-int I 0.00 2.00300.00 HLA067 11 30558118 30558164 ERV_0592264 MER4-int I 1.00 3.00 3.00HLA058 11 57714124 57714219 ERV_0607141 MER34-int I 0.00 2.00 300.00HLA053 11 68887856 68887871 ERV_0615645 MER101-int I 0.00 2.00 300.00HLA061 11 68887856 68887871 ERV_0615645 MER101-int I 0.00 1.93 300.00HLA072 11 68887856 68887871 ERV_0615645 MER101-int I 0.00 8.00 300.00HLA067 11 1.14E+08 1.14E+08 ERV_0645559 MSTA,MSTA-int LIL 0.00 1.86300.00 HLA072 11 1.21E+08 1.21E+08 ERV_0650459 ERVL-E-int I 0.00 2.00300.00 HLA065 11 45872343 45872457 ERV_0700157 MER57-int I 0.00 1.56300.00 HLA073 11 1.2E+08 1.2E+08 ERV_0766283 PRIMA4-int I 0.00 2.00300.00 HLA069 12 1.02E+08 1.02E+08 ERV_0867199 MER65-int I 0.00 2.80300.00 HLA082 13 23524412 23532857 ERV_0996915 HERV9NC-int,LTR12C LIL0.03 1.89 71.49 HLA053 13 94251480 94251714 ERV_1056462 MLT1H-int I 0.002.50 300.00 HLA065 13 91562053 91562121 ERV_1114439 ERVL-E-int I 0.001.71 300.00 HLA053 13 1E+08 1E+08 ERV_1120019 MER34-int I 0.00 2.00300.00 HLA061 14 50228354 50228682 ERV_1153268 LTR37-int,LTR37B LI 0.001.51 300.00 HLA063 14 68480483 68481099 ERV_1169312 MER34B-int I 0.002.25 300.00 HLA061 14 71039247 71039880 ERV_1237824 MLT1F,MLT1F-int LI0.80 2.72 3.40 HLA066 15 70688710 70689218 ERV_1309221 MLT1J,MLT1J-intLI 0.00 4.00 300.00 HLA058 15 64435855 64435891 ERV_1367176 ERVL-int I0.00 1.89 300.00 HLA065 16 71708060 71708575 ERV_1461030 HERVH-int,LTR7LI 0.00 1.70 300.00 HLA071 16 2915823 2916846 ERV_1481474LTR37-int,LTR37A LI 0.90 2.18 2.44 HLA073 17 36181655 36181703ERV_1576684 MLT-int I 0.00 1.66 300.00 HLA069 17 76664462 76664567ERV_1620562 HERV16-int I 0.00 1.57 300.00 HLA078 17 14025678 14026413ERV_1637737 MER89-int I 0.26 2.07 7.90 HLA072 17 31087849 31087921ERV_1647849 ERVL-int I 0.00 2.00 300.00 HLA065 17 32342830 32342978ERV_1649005 MSTD,MSTD-int LI 0.00 2.83 300.00 HLA072 17 4324964343249997 ERV_1657934 ERV3-16A3_I-int I 0.32 2.18 6.76 HLA069 18 1519922815199434 ERV_1760683 ERVL-E-int I 0.00 1.96 300.00 HLA065 19 1241879112421276 ERV_1810824 MER34-int I 0.27 1.57 5.83 HLA053 19 1599230915992400 ERV_1815774 THE1D-int I 0.00 2.00 300.00 HLA053 19 2379029723790393 ERV_1823978 MER57A-int I 0.00 2.38 300.00 HLA076 19 4397935543980979 ERV_1841932 ERVL-B4-int,MLT2C1 LI 1.78 3.86 2.16 HLA072 1951828006 51828656 ERV_1852225 MLT1J-int I 0.81 1.70 2.09 HLA061 1956380585 56381210 ERV_1857590 ERV3-16A3_I-int I 0.00 1.72 300.00 HLA06719 2826502 2826655 ERV_1862034 MER68-int I 0.36 1.92 5.35 HLA071 199825001 9825090 ERV_1869157 PABL_B-int I 0.46 3.00 6.51 HLA065 1912573722 12575780 ERV_1872113 LTR52,LTR52-int LI 0.82 5.33 6.54 HLA06719 52649340 52649401 ERV_1903573 HERVIP10B3-int I 1.00 2.30 2.30 HLA0662 8437515 8440768 ERV_1915295 HERV16-int I 0.17 1.98 11.48 HLA067 28437515 8440768 ERV_1915295 HERV16-int I 0.42 1.95 4.68 HLA072 2 84375158440768 ERV_1915295 HERV16-int I 0.73 2.85 3.89 HLA067 2 8441109 8441583ERV_1915298 HERV16-int I 0.63 1.89 3.00 HLA069 2 8441109 8441583ERV_1915298 HERV16-int I 0.92 2.04 2.21 HLA072 2 8441109 8441583ERV_1915298 HERV16-int I 0.59 6.31 10.71 HLA063 2 8828744 8829072ERV_1915636 MLT1-int I 0.00 3.17 300.00 HLA067 2 8828744 8829072ERV_1915636 MLT1-int I 0.00 1.63 300.00 HLA078 2 8828744 8829072ERV_1915636 MLT1-int I 0.00 1.50 300.00 HLA061 2 10003790 10004798ERV_1916838 ERVL-E-int,LTR33 LI 0.00 1.93 300.00 HLA066 2 1142531211426640 ERV_1918345 HERVH48-int,MER48 LI 0.00 1.55 300.00 HLA078 211797488 11798261 ERV_1918683 THE1D,THE1D-int LI 1.12 7.97 7.13 HLA078 211864859 11866327 ERV_1918742 ERV3-16A3_I-int,LTR16A1 LI 0.00 14.86300.00 HLA078 2 12569680 12575439 ERV_1919398 HERVH-int,LTR7Y LIL 0.001.58 300.00 HLA058 2 12858627 12862383 ERV_1919673 MLT1F2,MLT1F2-int LIL0.00 2.96 300.00 HLA058 2 15304068 15305786 ERV_1921825 THE1D,THE1D-intLIL 1.50 3.38 2.25 HLA065 2 15304068 15305786 ERV_1921825THE1D,THE1D-int LIL 0.18 1.90 10.75 HLA053 2 15370591 15371353ERV_1921898 THE1D,THE1D-int LI 0.33 2.31 6.91 HLA058 2 15865782 15867868ERV_1922377 MLT1G1,MLT1G1-int LIL 0.00 1.66 300.00 HLA061 2 1586578215867868 ERV_1922377 MLT1G1,MLT1G1-int LIL 1.49 3.10 2.08 HLA063 215865782 15867868 ERV_1922377 MLT1G1,MLT1G1-int LIL 0.63 2.74 4.37HLA065 2 15865782 15867868 ERV_1922377 MLT1G1,MLT1G1-int LIL 0.12 2.0917.06 HLA067 2 15865782 15867868 ERV_1922377 MLT1G1,MLT1G1-int LIL 0.365.17 14.42 HLA053 2 20268197 20268237 ERV_1926286 HERVL66-int I 0.782.75 3.55 HLA066 2 20268197 20268237 ERV_1926286 HERVL66-int I 0.00 1.85300.00 HLA066 2 21089108 21089599 ERV_1927021 MLT1J1,MLT1J1-int LI 0.302.34 7.86 HLA067 2 21089108 21089599 ERV_1927021 MLT1J1,MLT1J1-int LI1.76 5.72 3.25 HLA082 2 21396567 21398547 ERV_1927226ERV3-16A3_I-int,LTR16,LTR16A LIL 0.00 1.89 300.00 HLA067 2 2499234024992445 ERV_1930418 MER61-int I 0.00 1.86 300.00 HLA058 2 2532553825327302 ERV_1930816 ERVL-E-int,LTR41 LI 0.00 1.55 300.00 HLA071 225410436 25410584 ERV_1930909 LTR23-int I 0.00 1.88 300.00 HLA078 227162225 27167226 ERV_1932897 ERV24_Prim-int,LTR23 LI 0.01 2.77 541.13HLA072 2 32353519 32355800 ERV_1938025 MER31-int,MER31A LI 0.19 2.4913.10 HLA058 2 32532875 32533724 ERV_1938188 MLT1D-int I 0.66 3.01 4.56HLA061 2 32532875 32533724 ERV_1938188 MLT1D-int I 0.92 1.87 2.02 HLA0692 32532875 32533724 ERV_1938188 MLT1D-int I 0.28 2.15 7.64 HLA078 234677193 34678131 ERV_1940030 Harlequin-int,LTR2B LI 1.88 16.49 8.78HLA053 2 36564682 36564979 ERV_1941472 MLT1J-int I 0.00 2.73 300.00HLA078 2 36564682 36564979 ERV_1941472 MLT1J-int I 0.52 4.09 7.90 HLA0652 37160112 37160407 ERV_1942111 ERVL-B4-int I 0.00 3.19 300.00 HLA053 239219723 39220586 ERV_1944191 ERVL-E-int I 0.26 1.78 6.75 HLA058 239219723 39220586 ERV_1944191 ERVL-E-int I 0.43 4.49 10.54 HLA058 242773497 42783034 ERV_1947414 MER4-int,MER4A1 LIL 3.06 7.44 2.43 HLA0652 42773497 42783034 ERV_1947414 MER4-int,MER4A1 LIL 0.55 2.63 4.77HLA058 2 42775270 42782558 ERV_1947416 MER4-int I 3.06 7.44 2.43 HLA0652 42775270 42782558 ERV_1947416 MER4-int I 0.55 2.63 4.77 HLA073 242835193 42835480 ERV_1947484 MLT1H-int I 0.00 2.50 300.00 HLA058 243010014 43014936 ERV_1947634 MLT1J,MLT1J-int LIL 0.26 2.00 7.64 HLA0582 46903003 46905220 ERV_1951274 THE1A,THE1A-int LIL 56.2 2 475.52 8.46HLA067 2 46903003 46905220 ERV_1951274 THE1A,THE1A-int LIL 284, 58577.86 2.03 HLA069 2 46903003 46905220 ERV_1951274 THE1A,THE1A-int LIL150, 81 364.24 2.42 HLA071 2 46903003 46905220 ERV_1951274THE1A,THE1A-int LIL 232, 68 601.35 2.58 HLA076 2 46903003 46905220ERV_1951274 THE1A,THE1A-int LIL 136, 03 635.46 4.67 HLA053 2 4691846146919734 ERV_1951292 MLT1L,MLT1L-int LI 0.87 1.77 2.04 HLA058 2 4691846146919734 ERV_1951292 MLT1L,MLT1L-int LI 0.71 1.94 2.71 HLA066 2 4691846146919734 ERV_1951292 MLT1L,MLT1L-int LI 0.21 3.12 14.82 HLA078 246918461 46919734 ERV_1951292 MLT1L,MLT1L-int LI 0.93 2.80 3.01 HLA053 247868611 47870150 ERV_1952334 ERVL-B4-int,MLT2D LI 0.00 2.29 300.00HLA053 2 53704770 53705082 ERV_1957247 MER101-int I 0.05 3.57 69.63HLA069 2 53704770 53705082 ERV_1957247 MER101-int I 0.00 2.53 300.00HLA071 2 53704770 53705082 ERV_1957247 MER101-int I 1.42 3.57 2.52HLA053 2 53756643 53761425 ERV_1957309 HERV17-int,LTR17 LIL 0.81 3.534.37 HLA065 2 53756643 53761425 ERV_1957309 HERV17-int,LTR17 LIL 0.602.47 4.14 HLA067 2 53756643 53761425 ERV_1957309 HERV17-int,LTR17 LIL2.41 10.22 4.24 HLA065 2 53846882 53847622 ERV_1957413 ERVL-E-int I 0.002.44 300.00 HLA073 2 53846882 53847622 ERV_1957413 ERVL-E-int I 0.221.86 8.41 HLA053 2 54092460 54093159 ERV_1957703 ERV3-16A3_I-int,LTR16LI 0.00 2.14 300.00 HLA061 2 55625410 55626717 ERV_1959131ERV3-16A3_I-int,LTR16B1 LI 0.49 2.91 6.01 HLA063 2 55625410 55626717ERV_1959131 ERV3-16A3_I-int,LTR16B1 LI 2.03 4.33 2.13 HLA065 2 5562541055626717 ERV_1959131 ERV3-16A3_I-int,LTR16B1 LI 0.11 2.88 25.23 HLA067 255625410 55626717 ERV_1959131 ERV3-16A3_I-int,LTR16B1 LI 0.52 6.38 12.29HLA078 2 55625410 55626717 ERV_1959131 ERV3-16A3_I-int,LTR16B1 LI 0.042.66 60.02 HLA082 2 55625410 55626717 ERV_1959131ERV3-16A3_I-int,LTR16B1 LI 0.76 1.60 2.11 HLA072 2 60957288 60958158ERV_1963425 HERVL18-int,LTR18A LI 0.31 2.02 6.60 HLA066 2 6172134661721655 ERV_1964444 ERV3-16A3_I-int I 0.00 2.03 300.00 HLA078 261875631 61876008 ERV_1964662 MER41-int I 0.31 3.50 11.49 HLA053 262730625 62730785 ERV_1965455 HERVIP10FH-int I 2.94 13.78 4.69 HLA065 262730625 62730785 ERV_1965455 HERVIP10FH-int I 0.00 2.81 300.00 HLA072 262730625 62730785 ERV_1965455 HERVIP10FH-int I 1.08 3.48 3.24 HLA058 263988445 63997140 ERV_1966469 HERVK11-int,MER11B,MER11C LIL 0.21 5.4726.49 HLA058 2 64252414 64257646 ERV_1966699 HERVH-int,LTR7 LIL 0.976.17 6.39 HLA078 2 64252414 64257646 ERV_1966699 HERVH-int,LTR7 LIL 0.741.73 2.33 HLA058 2 65053217 65053895 ERV_1967539 ERVL-E-int I 0.44 1.733.89 HLA072 2 65053217 65053895 ERV_1967539 ERVL-E-int I 0.44 2.97 6.76HLA067 2 69318884 69318963 ERV_1971341 ERVL-B4-int I 0.44 1.68 3.80HLA076 2 69318884 69318963 ERV_1971341 ERVL-B4-int I 0.00 1.81 300.00HLA065 2 69450459 69450725 ERV_1971502 ERV24B_Prim-int I 0.10 1.96 19.33HLA066 2 69453399 69453528 ERV_1971511 MER57-int I 0.00 2.85 300.00HLA078 2 69453399 69453528 ERV_1971511 MER57-int I 0.00 2.00 300.00HLA078 2 71388099 71395817 ERV_1973505 HERVK22-int,LTR22E LIL 1.03 4.594.44 HLA072 2 71444089 71446102 ERV_1973538 ERVL-E-int I 1.35 3.91 2.89HLA078 2 71444089 71446102 ERV_1973538 ERVL-E-int I 0.82 1.77 2.17HLA061 2 72994297 72994549 ERV_1974905 ERVL-E-int I 0.08 5.48 72.68HLA072 2 72994297 72994549 ERV_1974905 ERVL-E-int I 1.12 2.50 2.23HLA078 2 73271213 73273836 ERV_1975221 MLT1K,MLT1K-int LIL 0.07 3.1645.26 HLA058 2 73738001 73738129 ERV_1975566 MST-int I 0.00 1.62 300.00HLA061 2 73738001 73738129 ERV_1975566 MST-int I 0.00 1.59 300.00 HLA0632 73738001 73738129 ERV_1975566 MST-int I 0.00 2.81 300.00 HLA066 273738001 73738129 ERV_1975566 MST-int I 0.00 2.70 300.00 HLA069 285817949 85818174 ERV_1985980 ERVL-E-int I 0.00 2.27 300.00 HLA067 287039336 87043487 ERV_1987156 LTR28C,MER52-int LI 0.40 1.61 4.01 HLA0712 87039336 87043487 ERV_1987156 LTR28C,MER52-int LI 0.37 1.85 4.99HLA066 2 87590144 87592567 ERV_1987621 MSTA,MSTA-int LIL 0.09 1.50 17.34HLA078 2 87590144 87592567 ERV_1987621 MSTA,MSTA-int LIL 0.16 2.45 15.43HLA053 2 88581793 88582614 ERV_1988703 HERVL-int I 0.25 5.03 20.34HLA069 2 88581793 88582614 ERV_1988703 HERVL-int I 1.46 3.28 2.24 HLA0582 88679963 88686725 ERV_1988796 MER50,MER50-int LIL 0.75 3.71 4.95HLA061 2 88679963 88686725 ERV_1988796 MER50,MER50-int LIL 0.68 1.652.42 HLA078 2 88679963 88686725 ERV_1988796 MER50,MER50-int LIL 0.293.34 11.57 HLA061 2 90224760 90225079 ERV_1989710 ERVL-B4-int I 0.005.54 300.00 HLA061 2 90227941 90228534 ERV_1989713 MER70-int,MER70A LI0.00 2.48 300.00 HLA061 2 90228581 90231442 ERV_1989714 MER66-int,MER66ALI 0.00 1.57 300.00 HLA063 2 94229830 94230277 ERV_1990538MER34B-int,MER34C_ LI 0.00 1.91 300.00 HLA067 2 94229830 94230277ERV_1990538 MER34B-int,MER34C_ LI 0.00 2.61 300.00 HLA065 2 9515429095156042 ERV_1991061 MLT1I,MLT1I-int LIL 0.15 1.90 12.78 HLA078 295154290 95156042 ERV_1991061 MLT1I,MLT1I-int LIL 0.95 3.45 3.62 HLA0582 96233989 96239799 ERV_1991992 ERV3-16A3_I-int,LTR16A,LTR16B2 LIL 0.292.14 7.36 HLA069 2 96233989 96239799 ERV_1991992ERV3-16A3_I-int,LTR16A,LTR16B2 LIL 0.76 1.73 2.27 HLA078 2 9623398996239799 ERV_1991992 ERV3-16A3_I-int,LTR16A,LTR16B2 LIL 0.58 2.24 3.85HLA058 2 96235418 96238331 ERV_1991997 ERVL-E-int I 0.29 2.14 7.36HLA069 2 96235418 96238331 ERV_1991997 ERVL-E-int I 0.76 1.73 2.27HLA078 2 96235418 96238331 ERV_1991997 ERVL-E-int I 0.58 2.24 3.85HLA072 2 96315157 96315867 ERV_1992080 HERVL40-int,LTR40c LI 0.95 2.362.49 HLA065 2 96565704 96572402 ERV_1992320 MER92-int,MER92D LI 0.001.71 300.00 HLA053 2 99200956 99201109 ERV_1994513 MER110-int I 2.636.44 2.45 HLA058 2 99200956 99201109 ERV_1994513 MER110-int I 0.00 7.93300.00 HLA067 2 99200956 99201109 ERV_1994513 MER110-int I 0.00 11.39300.00 HLA071 2 99200956 99201109 ERV_1994513 MER110-int I 1.00 4.904.90 HLA072 2 99200956 99201109 ERV_1994513 MER110-int I 0.45 9.18 20.35HLA076 2 99200956 99201109 ERV_1994513 MER110-int I 2.54 10.27 4.04HLA082 2 99200956 99201109 ERV_1994513 MER110-int I 2.78 13.31 4.78HLA053 2 99201154 99201453 ERV_1994514 MER89-int I 2.62 7.65 2.92 HLA0582 99201154 99201453 ERV_1994514 MER89-int I 0.00 7.97 300.00 HLA067 299201154 99201453 ERV_1994514 MER89-int I 0.56 5.86 10.55 HLA071 299201154 99201453 ERV_1994514 MER89-int I 0.52 3.63 7.05 HLA076 299201154 99201453 ERV_1994514 MER89-int I 2.92 7.17 2.45 HLA082 299201154 99201453 ERV_1994514 MER89-int I 2.47 5.33 2.16 HLA063 299236693 99238143 ERV_1994543 MER21-int I 0.88 3.54 4.02 HLA065 299236693 99238143 ERV_1994543 MER21-int I 2.60 6.39 2.46 HLA072 299236693 99238143 ERV_1994543 MER21-int I 0.71 5.54 7.80 HLA058 299238180 99238330 ERV_1994545 MER21-int I 0.23 2.20 9.71 HLA061 299238180 99238330 ERV_1994545 MER21-int I 0.00 4.29 300.00 HLA063 299238180 99238330 ERV_1994545 MER21-int I 0.13 2.04 16.11 HLA065 299238180 99238330 ERV_1994545 MER21-int I 0.00 2.03 300.00 HLA072 299238180 99238330 ERV_1994545 MER21-int I 0.00 6.24 300.00 HLA053 299303711 99304487 ERV_1994616 THE1B,THE1B-int LIL 0.75 2.78 3.70 HLA0582 99303711 99304487 ERV_1994616 THE1B,THE1B-int LIL 0.00 1.53 300.00HLA058 2 1E+08 1E+08 ERV_1995473 HERVL74-int,MER74B LIL 0.78 8.66 11.12HLA058 2 1.01E+08 1.01E+08 ERV_1996284 ERVL-E-int,LTR33 LI 0.38 4.9813.11 HLA069 2 1.01E+08 1.01E+08 ERV_1996284 ERVL-E-int,LTR33 LI 0.641.93 3.01 HLA053 2 1.02E+08 1.02E+08 ERV_1997060 HERVIP10FH-int I 8.6830.40 3.50 HLA061 2 1.09E+08 1.09E+08 ERV_2002448 Harlequin-int,LTR2 LIL0.46 1.54 3.34 HLA063 2 1.09E+08 1.09E+08 ERV_2002448 Harlequin-int,LTR2LIL 0.16 1.67 10.72 HLA071 2 1.09E+08 1.09E+08 ERV_2002448Harlequin-int,LTR2 LIL 0.42 2.06 4.96 HLA058 2 1.1E+08 1.1E+08ERV_2003903 ERVL-B4-int,MLT2C1 LI 2.66 13.03 4.91 HLA065 2 1.1E+081.1E+08 ERV_2003903 ERVL-B4-int,MLT2C1 LI 2.60 7.31 2.81 HLA067 21.1E+08 1.1E+08 ERV_2003903 ERVL-B4-int,MLT2C1 LI 1.05 2.91 2.78 HLA0582 1.13E+08 1.13E+08 ERV_2005804 HERVL40-int I 0.95 3.65 3.84 HLA065 21.13E+08 1.13E+08 ERV_2005804 HERVL40-int I 1.13 3.39 2.99 HLA071 21.13E+08 1.13E+08 ERV_2005804 HERVL40-int I 2.40 5.19 2.16 HLA072 21.13E+08 1.13E+08 ERV_2005804 HERVL40-int I 2.13 6.68 3.14 HLA073 21.13E+08 1.13E+08 ERV_2005804 HERVL40-int I 1.74 4.19 2.41 HLA082 21.13E+08 1.13E+08 ERV_2005804 HERVL40-int I 1.01 4.71 4.69 HLA053 21.13E+08 1.13E+08 ERV_2005885 ERVL-E-int I 0.59 2.05 3.46 HLA063 21.13E+08 1.13E+08 ERV_2006565 THE1B,THE1B-int LIL 2.40 6.42 2.67 HLA0712 1.13E+08 1.13E+08 ERV_2006565 THE1B,THE1B-int LIL 2.88 5.95 2.06HLA073 2 1.13E+08 1.13E+08 ERV_2006565 THE1B,THE1B-int LIL 0.57 2.334.05 HLA076 2 1.13E+08 1.13E+08 ERV_2006565 THE1B,THE1B-int LIL 1.4812.31 8.32 HLA066 2 1.14E+08 1.14E+08 ERV_2006715 MER31-int I 1.78 5.353.00 HLA058 2 1.14E+08 1.14E+08 ERV_2006716 MER92-int I 0.19 1.55 8.12HLA073 2 1.14E+08 1.14E+08 ERV_2006718 MER92-int I 0.45 1.54 3.45 HLA0722 1.17E+08 1.17E+08 ERV_2009540 MSTA,MSTA-int LIL 0.00 1.65 300.00HLA066 2 1.18E+08 1.18E+08 ERV_2010325 THE1B,THE1B-int LIL 0.75 1.712.28 HLA071 2 1.18E+08 1.18E+08 ERV_2010325 THE1B,THE1B-int LIL 0.311.75 5.59 HLA063 2 1.21E+08 1.21E+08 ERV_2013434 MSTA,MSTA-int LIL 0.614.91 8.08 HLA065 2 1.21E+08 1.21E+08 ERV_2013434 MSTA,MSTA-int LIL 1.085.78 5.37 HLA072 2 1.21E+08 1.21E+08 ERV_2013434 MSTA,MSTA-int LIL 1.353.34 2.48 HLA065 2 1.28E+08 1.28E+08 ERV_2019273 ERVL-E-int I 0.00 3.18300.00 HLA067 2 1.28E+08 1.28E+08 ERV_2019273 ERVL-E-int I 0.00 2.81300.00 HLA058 2 1.3E+08 1.3E+08 ERV_2021040 MER101-int,MER65C LI 0.003.30 300.00 HLA069 2 1.3E+08 1.3E+08 ERV_2021067 MST-int I 0.00 2.02300.00 HLA069 2 1.3E+08 1.3E+08 ERV_2021069 THE1D-int I 0.00 2.02 300.00HLA058 2 1.31E+08 1.31E+08 ERV_2022115 MER4-int I 0.00 2.12 300.00HLA058 2 1.31E+08 1.31E+08 ERV_2022123 MSTA,MSTA-int LI 0.00 2.83 300.00HLA058 2 1.31E+08 1.31E+08 ERV_2022124 THE1D-int I 0.00 2.83 300.00HLA069 2 1.32E+08 1.32E+08 ERV_2022303 ERVL-B4-int,MLT2B1 LI 0.00 1.90300.00 HLA058 2 1.32E+08 1.32E+08 ERV_2022331 MER4-int,MER4A1 LI 0.002.01 300.00 HLA058 2 1.32E+08 1.32E+08 ERV_2022376 MER4-int I 0.66 32.9649.76 HLA058 2 1.36E+08 1.36E+08 ERV_2025737 MER4B-int,MER4E LI 0.291.54 5.32 HLA065 2 1.36E+08 1.36E+08 ERV_2025737 MER4B-int,MER4E LI 0.431.79 4.12 HLA067 2 1.43E+08 1.43E+08 ERV_2032133 THE1B,THE1B-int LIL1.24 3.13 2.52 HLA058 2 1.45E+08 1.45E+08 ERV_2033576 MLT1J1,MLT1J1-intLI 0.00 4.29 300.00 HLA058 2 1.45E+08 1.45E+08 ERV_2033871MLT1F2,MLT1F2-int LI 0.00 9.49 300.00 HLA065 2 1.6E+08 1.6E+08ERV_2045461 LTR37-int I 0.31 2.46 7.98 HLA058 2 1.7E+08 1.7E+08ERV_2053727 MSTB1,MSTB1-int LIL 0.30 4.20 13.87 HLA065 2 1.7E+08 1.7E+08ERV_2053727 MSTB1,MSTB1-int LIL 0.33 2.40 7.39 HLA067 2 1.7E+08 1.7E+08ERV_2053727 MSTB1,MSTB1-int LIL 0.48 2.49 5.16 HLA072 2 1.7E+08 1.7E+08ERV_2053727 MSTB1,MSTB1-int LIL 0.17 2.93 16.81 HLA066 2 1.7E+08 1.7E+08ERV_2054017 MLT1I,MLT1I-int LI 0.10 1.97 20.46 HLA058 2 1.7E+08 1.7E+08ERV_2054018 MLT1I-int I 0.00 1.97 300.00 HLA067 2 1.71E+08 1.71E+08ERV_2054890 MLT1D,MLT1D-int LI 0.00 1.70 300.00 HLA058 2 1.71E+081.71E+08 ERV_2055246 LTR79,THE1B,THE1B-int LIL 0.81 2.49 3.08 HLA069 21.71E+08 1.71E+08 ERV_2055246 LTR79,THE1B,THE1B-int LIL 0.48 1.51 3.14HLA065 2 1.72E+08 1.72E+08 ERV_2055877 MLT1D,MLT1D-int LI 0.67 3.09 4.64HLA072 2 1.78E+08 1.78E+08 ERV_2060929 HERV35I-int I 0.00 1.89 300.00HLA065 2 1.78E+08 1.78E+08 ERV_2061533 HERV17-int,LTR17 LIL 0.25 1.525.97 HLA071 2 1.79E+08 1.79E+08 ERV_2062230 MER41-int,MER41B LI 0.612.81 4.60 HLA065 2 1.86E+08 1.86E+08 ERV_2066852 THE1A,THE1A-int LIL0.00 2.80 300.00 HLA066 2 1.87E+08 1.87E+08 ERV_2067643HERVK-int,LTR5B,LTR5_Hs LIL 0.95 1.97 2.07 HLA082 2 1.87E+08 1.87E+08ERV_2068265 LTR37-int,LTR37A LIL 0.72 1.60 2.22 HLA082 2 1.87E+081.87E+08 ERV_2068268 LTR37-int I 0.72 1.60 2.22 HLA058 2 1.87E+081.87E+08 ERV_2068404 THE1-int I 0.00 1.55 300.00 HLA065 2 1.87E+081.87E+08 ERV_2068404 THE1-int I 0.00 2.08 300.00 HLA067 2 1.87E+081.87E+08 ERV_2068404 THE1-int I 0.00 1.74 300.00 HLA067 2 1.88E+081.88E+08 ERV_2068412 Harlequin-int,LTR2 LIL 2.59 5.95 2.30 HLA069 21.88E+08 1.88E+08 ERV_2068412 Harlequin-int,LTR2 LIL 1.39 3.02 2.18HLA067 2 1.88E+08 1.88E+08 ERV_2068413 HERVE_a-int I 2.59 5.95 2.30HLA069 2 1.88E+08 1.88E+08 ERV_2068413 HERVE_a-int I 1.39 3.02 2.18HLA066 2 1.91E+08 1.91E+08 ERV_2071264 MSTB1,MSTB1-int LIL 0.17 1.629.26 HLA071 2 1.91E+08 1.91E+08 ERV_2071264 MSTB1,MSTB1-int LIL 1.317.04 5.36 HLA072 2 1.91E+08 1.91E+08 ERV_2071264 MSTB1,MSTB1-int LIL0.76 2.29 3.02 HLA073 2 1.91E+08 1.91E+08 ERV_2071264 MSTB1,MSTB1-intLIL 1.13 3.78 3.33 HLA067 2 2.01E+08 2.01E+08 ERV_2079453ERV3-16A3_I-int I 1.61 17.15 10.64 HLA069 2 2.01E+08 2.01E+08ERV_2079453 ERV3-16A3_I-int I 0.09 5.18 59.88 HLA071 2 2.01E+08 2.01E+08ERV_2079453 ERV3-16A3_I-int I 3.53 11.49 3.26 HLA082 2 2.01E+08 2.01E+08ERV_2079453 ERV3-16A3_I-int I 0.98 6.85 6.97 HLA073 2 2.01E+08 2.01E+08ERV_2079783 MER4-int I 0.00 1.61 300.00 HLA072 2 2.01E+08 2.01E+08ERV_2079826 MER21-int I 0.80 1.65 2.07 HLA065 2 2.03E+08 2.03E+08ERV_2082200 MER92-int I 1.31 11.42 8.69 HLA067 2 2.06E+08 2.06E+08ERV_2084847 MSTB,MSTB-int LI 18.3 7 51.21 2.79 HLA069 2 2.06E+082.06E+08 ERV_2084847 MSTB,MSTB-int LI 13.0 9 30.95 2.37 HLA076 22.06E+08 2.06E+08 ERV_2084847 MSTB,MSTB-int LI 23.1 6 54.92 2.37 HLA0692 2.09E+08 2.09E+08 ERV_2087240 ERVL-E-int I 0.00 2.34 300.00 HLA071 22.09E+08 2.09E+08 ERV_2087240 ERVL-E-int I 1.26 3.77 2.99 HLA065 22.1E+08 2.1E+08 ERV_2088191 THE1C,THE1C-int LI 0.00 2.21 923.49 HLA072 22.1E+08 2.1E+08 ERV_2088191 THE1C,THE1C-int LI 1.08 4.17 3.86 HLA065 22.1E+08 2.1E+08 ERV_2088204 MLT1H2,MLT1H2-int LI 0.06 2.24 35.80 HLA0722 2.1E+08 2.1E+08 ERV_2088204 MLT1H2,MLT1H2-int LI 0.14 1.81 13.03HLA065 2 2.1E+08 2.1E+08 ERV_2088206 MLT1H2-int I 0.06 2.24 35.80 HLA0722 2.1E+08 2.1E+08 ERV_2088206 MLT1H2-int I 0.14 1.81 13.03 HLA063 22.16E+08 2.16E+08 ERV_2093181 ERV3-16A3_I-int,LTR16B LIL 3.70 14.64 3.96HLA065 2 2.16E+08 2.16E+08 ERV_2093181 ERV3-16A3_I-int,LTR16B LIL 1.577.96 5.07 HLA066 2 2.16E+08 2.16E+08 ERV_2093181 ERV3-16A3_I-int,LTR16BLIL 2.83 10.66 3.77 HLA067 2 2.16E+08 2.16E+08 ERV_2093181ERV3-16A3_I-int,LTR16B LIL 8.14 44.25 5.44 HLA069 2 2.16E+08 2.16E+08ERV_2093181 ERV3-16A3_I-int,LTR16B LIL 1.38 4.58 3.31 HLA072 2 2.16E+082.16E+08 ERV_2093181 ERV3-16A3_I-int,LTR16B LIL 1.50 5.23 3.48 HLA073 22.16E+08 2.16E+08 ERV_2093181 ERV3-16A3_I-int,LTR16B LIL 2.18 6.71 3.08HLA082 2 2.16E+08 2.16E+08 ERV_2093181 ERV3-16A3_I-int,LTR16B LIL 3.597.44 2.07 HLA061 2 2.16E+08 2.16E+08 ERV_2093269 MLT1F,MLT1F-int LI 0.002.44 300.00 HLA063 2 2.16E+08 2.16E+08 ERV_2093269 MLT1F,MLT1F-int LI0.00 2.10 300.00 HLA067 2 2.16E+08 2.16E+08 ERV_2093269 MLT1F,MLT1F-intLI 0.29 1.65 5.65 HLA067 2 2.23E+08 2.23E+08 ERV_2099640 MER57A-int I0.06 1.96 30.79 HLA067 2 2.23E+08 2.23E+08 ERV_2099641 MER57A-int I 0.002.33 300.00 HLA073 2 2.23E+08 2.23E+08 ERV_2099643 MER101-int I 0.441.57 3.61 HLA065 2 2.24E+08 2.24E+08 ERV_2100712 THE1B,THE1B-int LIL0.13 2.21 17.57 HLA067 2 2.24E+08 2.24E+08 ERV_2100712 THE1B,THE1B-intLIL 0.84 4.21 5.03 HLA082 2 2.24E+08 2.24E+08 ERV_2100712THE1B,THE1B-int LIL 0.65 2.81 4.30 HLA067 2 2.3E+08 2.3E+08 ERV_2106597HERVL-int,MLT2A1 LIL 0.16 4.13 26.41 HLA067 2 2.3E+08 2.3E+08ERV_2106642 LTR53-int I 2.17 5.04 2.33 HLA067 2 2.3E+08 2.3E+08ERV_2106779 ERV3-16A3_I-int,LTR16A1 LI 2.40 7.09 2.95 HLA072 2 2.31E+082.31E+08 ERV_2106847 LOR1-int,LOR1a LIL 1.64 3.54 2.16 HLA072 2 2.31E+082.31E+08 ERV_2106856 LOR1-int I 1.64 3.54 2.16 HLA065 2 2.31E+082.31E+08 ERV_2106916 MLT1G,MLT1G-int LI 0.00 2.20 300.00 HLA072 22.32E+08 2.32E+08 ERV_2108130 THE1A,THE1A-int LIL 0.62 1.75 2.81 HLA0722 2.33E+08 2.33E+08 ERV_2109103 ERVL-E-int I 0.00 2.12 300.00 HLA065 22.33E+08 2.33E+08 ERV_2109456 MLT1-int I 1.18 2.67 2.27 HLA072 22.33E+08 2.33E+08 ERV_2109456 MLT1-int I 0.34 2.17 6.34 HLA065 22.33E+08 2.33E+08 ERV_2109457 MLT1-int I 1.18 2.67 2.27 HLA072 22.33E+08 2.33E+08 ERV_2109457 MLT1-int I 0.34 2.17 6.34 HLA069 22.34E+08 2.34E+08 ERV_2110157 THE1C,THE1C-int LI 0.16 1.61 10.35 HLA0762 2.34E+08 2.34E+08 ERV_2110157 THE1C,THE1C-int LI 0.00 1.73 300.00HLA063 2 2.34E+08 2.34E+08 ERV_2110158 THE1C,THE1C-int LI 0.47 1.52 3.27HLA065 2 2.34E+08 2.34E+08 ERV_2110158 THE1C,THE1C-int LI 0.00 2.19300.00 HLA076 2 2.34E+08 2.34E+08 ERV_2110158 THE1C,THE1C-int LI 0.952.55 2.68 HLA063 2 2.34E+08 2.34E+08 ERV_2110163 THE1C,THE1C-int LI 0.652.13 3.29 HLA066 2 2.34E+08 2.34E+08 ERV_2110163 THE1C,THE1C-int LI 0.583.19 5.54 HLA071 2 2.34E+08 2.34E+08 ERV_2110163 THE1C,THE1C-int LI 2.5916.89 6.51 HLA073 2 2.34E+08 2.34E+08 ERV_2110163 THE1C,THE1C-int LI0.96 3.48 3.63 HLA076 2 2.34E+08 2.34E+08 ERV_2110163 THE1C,THE1C-int LI1.76 8.21 4.67 HLA071 2 2.34E+08 2.34E+08 ERV_2110164 THE1C,THE1C-int LI4.79 20.25 4.23 HLA076 2 2.34E+08 2.34E+08 ERV_2110164 THE1C,THE1C-intLI 2.69 15.98 5.95 HLA061 2 2.35E+08 2.35E+08 ERV_2110936MamGyp-int,MamGypLTR1d LI 0.41 2.46 5.96 HLA069 2 2.35E+08 2.35E+08ERV_2110936 MamGyp-int,MamGypLTR1d LI 0.00 2.18 300.00 HLA071 2 2.35E+082.35E+08 ERV_2110936 MamGyp-int,MamGypLTR1d LI 0.14 3.33 23.93 HLA069 22.35E+08 2.35E+08 ERV_2110985 MamRep605,THE1B,THE 1B-int LIL 0.03 2.2073.94 HLA071 2 2.38E+08 2.38E+08 ERV_2113834 MLTIJ-int I 1.78 4.05 2.27HLA082 2 2.38E+08 2.38E+08 ERV_2113834 MLTIJ-int I 0.00 2.61 300.00HLA065 2 2.38E+08 2.38E+08 ERV_2114006 ERV3-16A3_I-int I 0.00 1.98300.00 HLA067 2 2.38E+08 2.38E+08 ERV_2114006 ERV3-16A3_I-int I 0.002.57 300.00 HLA076 2 2.38E+08 2.38E+08 ERV_2114006 ERV3-16A3_I-int I0.00 2.23 300.00 HLA082 2 2.38E+08 2.38E+08 ERV_2114006 ERV3-16A3_I-intI 0.32 3.40 10.48 HLA065 2 2.41E+08 2.41E+08 ERV_2115527 LOR1-int,LOR1bLI 0.74 1.52 2.04 HLA067 2 2.41E+08 2.41E+08 ERV_2115527 LOR1-int,LOR1bLI 0.00 1.66 300.00 HLA066 2 2.41E+08 2.41E+08 ERV_2115570THE1D,THE1D-int LIL 0.44 3.95 8.97 HLA065 2 2.41E+08 2.41E+08ERV_2115723 MER84,MER84-int LIL 0.30 1.85 6.20 HLA065 2 2.41E+082.41E+08 ERV_2115727 MER84-int I 0.30 1.85 6.20 HLA065 2 2.42E+082.42E+08 ERV_2116259 ERVL-B4-int I 1.11 6.45 5.79 HLA066 2 2.42E+082.42E+08 ERV_2116259 ERVL-B4-int I 4.63 19.13 4.13 HLA067 2 2.42E+082.42E+08 ERV_2116259 ERVL-B4-int I 10.26 23.32 2.27 HLA069 2 2.42E+082.42E+08 ERV_2116259 ERVL-B4-int I 2.66 31.86 12.00 HLA071 2 2.42E+082.42E+08 ERV_2116259 ERVL-B4-int I 17.51 43.16 2.47 HLA073 2 2.42E+082.42E+08 ERV_2116259 ERVL-B4-int I 4.68 12.23 2.61 HLA076 2 2.42E+082.42E+08 ERV_2116259 ERVL-B4-int I 10.37 26.78 2.58 HLA058 2 2.42E+082.42E+08 ERV_2116428 ERVL-B4-int I 0.73 3.94 5.38 HLA061 2 2.42E+082.42E+08 ERV_2116428 ERVL-B4-int I 0.87 2.23 2.58 HLA067 2 2.42E+082.42E+08 ERV_2116428 ERVL-B4-int I 0.17 10.14 60.87 HLA073 2 2.42E+082.42E+08 ERV_2116428 ERVL-B4-int I 1.00 3.79 3.79 HLA072 2 82971978302648 ERV_2120801 ERV3-16A3_I-int,LTR16A LI 0.86 5.58 6.50 HLA061 210199041 10199842 ERV_2122088 PABL_A-int I 0.97 14.15 14.57 HLA063 210199041 10199842 ERV_2122088 PABL_A-int I 0.89 2.14 2.40 HLA067 210199041 10199842 ERV_2122088 PABL_A-int I 0.17 1.80 10.30 HLA072 210199041 10199842 ERV_2122088 PABL_A-int I 0.85 4.73 5.59 HLA078 210199041 10199842 ERV_2122088 PABL_A-int I 0.43 4.00 9.32 HLA061 210200132 10202321 ERV_2122090 PABL_A-int I 0.39 4.55 11.69 HLA072 210200132 10202321 ERV_2122090 PABL_A-int I 0.35 2.02 5.78 HLA078 210200132 10202321 ERV_2122090 PABL_A-int I 0.69 1.74 2.51 HLA063 211436974 11437120 ERV_2123067 ERVL-E-int I 0.00 2.41 300.00 HLA078 213325730 13330417 ERV_2124376 ERV3-16A3_I-int,LTR16A LI 0.00 1.59 300.00HLA078 2 13431355 13434329 ERV_2124414 THE1B,THE1B-int LIL 0.00 18.43300.00 HLA078 2 13436368 13443553 ERV_2124417 ERV3-16A3_I-int,LTR16A LIL0.00 4.37 300.00 HLA078 2 13437433 13438610 ERV_2124418 THE1D,THE1D-intLIL 0.00 4.37 300.00 HLA078 2 13438615 13443239 ERV_2124419 HERV16-int I0.00 4.37 300.00 HLA078 2 13519979 13520093 ERV_2124475 LTR23-int I 0.00273.36 300.00 HLA078 2 13520104 13523277 ERV_2124476 LTR49-int I 0.0030.62 300.00 HLA058 2 13525956 13533609 ERV_2124481 Harlequin-int,LTR2LIL 0.00 2.75 700.37 HLA078 2 13525956 13533609 ERV_2124481Harlequin-int,LTR2 LIL 0.00 81.75 300.00 HLA058 2 13532712 13533096ERV_2124482 HERVE_a-int I 0.00 2.75 700.37 HLA078 2 13532712 13533096ERV_2124482 HERVE_a-int I 0.00 81.75 300.00 HLA073 2 20404559 20408382ERV_2128633 MER57A-int I 0.00 34.84 300.00 HLA063 2 20418623 20418884ERV_2128644 MER57A-int I 0.00 1.70 300.00 HLA078 2 20927545 20929807ERV_2128971 THE1D,THE1D-int LIL 0.08 2.03 24.98 HLA065 2 2110208221102299 ERV_2129068 HERV9N-int I 0.00 5.49 300.00 HLA069 2 2110208221102299 ERV_2129068 HERV9N-int I 0.00 1.60 300.00 HLA065 2 2118049821184746 ERV_2129138 ERVL-E-int I 0.00 1.75 300.00 HLA065 2 2455438424555134 ERV_2131158 HUERS-P3-int,LTR9 LIL 0.00 2.13 300.00 HLA053 226256938 26259651 ERV_2132444 HERVK22-int,LTR22A LI 4.64 15.94 3.44HLA067 2 26256938 26259651 ERV_2132444 HERVK22-int,LTR22A LI 3.36 12.803.81 HLA058 2 26402437 26405320 ERV_2132556 ERV3-16A3_I-int I 0.55 2.193.96 HLA072 2 28424530 28424992 ERV_2134227 MLT1J,MLT1J-int LI 0.38 1.935.10 HLA076 2 28424530 28424992 ERV_2134227 MLT1J,MLT1J-int LI 0.29 1.786.23 HLA078 2 28424530 28424992 ERV_2134227 MLT1J,MLT1J-int LI 0.00 1.87300.00 HLA053 2 31687476 31695509 ERV_2136406 HUERS-P3-int,LTR9A1 LIL2.38 5.44 2.28 HLA078 2 31687476 31695509 ERV_2136406HUERS-P3-int,LTR9A1 LIL 0.25 3.65 14.83 HLA053 2 34737167 34738420ERV_2138690 ERV3-16A3_I-int I 2.88 5.85 2.03 HLA078 2 34737167 34738420ERV_2138690 ERV3-16A3_I-int I 0.88 8.01 9.14 HLA078 2 35632310 35633124ERV_2139104 THE1D,THE1D-int LI 0.07 1.66 23.24 HLA065 2 4308900143092977 ERV_2143938 MLT1G1,MLT1G1-int LIL 1.93 4.65 2.40 HLA061 244058911 44061035 ERV_2144621 THE1C,THE1C-int LI 26.54 71.10 2.68 HLA0652 44058911 44061035 ERV_2144621 THE1C,THE1C-int LI 1.29 2.76 2.13 HLA0662 44058911 44061035 ERV_2144621 THE1C,THE1C-int LI 3.74 15.94 4.27HLA067 2 44058911 44061035 ERV_2144621 THE1C,THE1C-int LI 22.08 165.807.51 HLA071 2 44058911 44061035 ERV_2144621 THE1C,THE1C-int LI 20.98237.43 11.32 HLA073 2 44058911 44061035 ERV_2144621 THE1C,THE1C-int LI1.06 15.25 14.40 HLA076 2 44058911 44061035 ERV_2144621 THE1C,THE1C-intLI 4.06 65.78 16.22 HLA071 2 46962700 46964031 ERV_2146615MLT1K,MLT1K-int LI 0.00 1.64 300.00 HLA067 2 46973328 46974023ERV_2146632 LTR38-int I 0.00 1.93 300.00 HLA058 2 47689825 47699818ERV_2147254 MER34B-int,MER34C_ LI 1.51 4.15 2.75 HLA058 2 4769166047699393 ERV_2147256 LTR49,LTR49-int LI 1.51 4.15 2.75 HLA058 2 4769444947696082 ERV_2147262 LTR49-int I 1.51 4.15 2.75 HLA071 2 5493875454938933 ERV_2151506 MLTIJ-int I 0.00 1.85 300.00 HLA065 2 5821016158212447 ERV_2153309 THE1B,THE1B-int LIL 0.12 2.34 19.13 HLA072 261063247 61063691 ERV_2154855 MLT1J2,MLT1J2-int LI 0.00 2.34 300.00HLA066 2 63678018 63679739 ERV_2156783 MLT1J,MLT1J-int LI 0.15 8.7857.21 HLA069 2 63678018 63679739 ERV_2156783 MLT1J,MLT1J-int LI 0.001.82 300.00 HLA073 2 63678018 63679739 ERV_2156783 MLT1J,MLT1J-int LI0.47 7.24 15.48 HLA076 2 63678018 63679739 ERV_2156783 MLT1J,MLT1J-intLI 0.56 5.57 9.91 HLA058 2 65044777 65046931 ERV_2157742 HERVIP10FH-intI 0.48 2.35 4.84 HLA072 2 65044777 65046931 ERV_2157742 HERVIP10FH-int I0.29 3.33 11.38 HLA078 2 65044777 65046931 ERV_2157742 HERVIP10FH-int I0.13 1.55 11.68 HLA072 2 68493613 68497825 ERV_2159806 MSTA,MSTA-int LIL0.09 1.88 20.00 HLA072 2 69773589 69777599 ERV_2160690 MER21-int,MER21CLI 0.34 1.60 4.67 HLA058 2 69789458 69799610 ERV_2160711LTR19C,LTR25-int LIL 0.29 2.26 7.79 HLA072 2 69789458 69799610ERV_2160711 LTR19C,LTR25-int LIL 0.45 1.59 3.53 HLA058 2 6979478269798802 ERV_2160713 HUERS-P3-int I 0.29 2.26 7.79 HLA072 2 6979478269798802 ERV_2160713 HUERS-P3-int I 0.45 1.59 3.53 HLA053 2 7261649772617510 ERV_2162606 THE1B,THE1B-int LI 0.68 1.70 2.51 HLA065 2 7261649772617510 ERV_2162606 THE1B,THE1B-int LI 0.40 2.58 6.40 HLA072 2 7261649772617510 ERV_2162606 THE1B,THE1B-int LI 0.00 3.39 300.00 HLA072 273738942 73742448 ERV_2163374 MER70-int,MER70A LIL 0.57 1.78 3.11 HLA0582 75385796 75386233 ERV_2164528 PABL_A-int I 0.00 2.23 300.00 HLA076 279163171 79170353 ERV_2166416 HERV17-int,LTR17 LIL 0.02 4.11 221.89HLA078 2 79163171 79170353 ERV_2166416 HERV17-int,LTR17 LIL 0.00 9.80300.00 HLA065 2 81753539 81756070 ERV_2167912 THE1A,THE1A-int LIL 0.012.81 296.60 HLA058 2 84470760 84477426 ERV_2169282 HERVK14-int,LTR14BLIL 0.13 1.77 13.44 HLA058 2 85290829 85290944 ERV_2169950 MLT-int I0.50 3.74 7.41 HLA066 2 85290829 85290944 ERV_2169950 MLT-int I 0.001.97 300.00 HLA066 2 85290954 85291520 ERV_2169951 MLT1-int I 0.00 2.04300.00 HLA058 2 85378291 85384270 ERV_2170026 MER4-int,MER4A1 LIL 0.781.58 2.03 HLA061 2 85378291 85384270 ERV_2170026 MER4-int,MER4A1 LIL0.56 1.58 2.83 HLA065 2 85378291 85384270 ERV_2170026 MER4-int,MER4A1LIL 0.71 2.35 3.32 HLA067 2 85378291 85384270 ERV_2170026MER4-int,MER4A1 LIL 0.49 1.50 3.06 HLA072 2 85378291 85384270ERV_2170026 MER4-int,MER4A1 LIL 0.90 2.21 2.45 HLA078 2 8537829185384270 ERV_2170026 MER4-int,MER4A1 LIL 0.53 1.72 3.23 HLA065 285452806 85452853 ERV_2170087 HERV9N-int I 0.00 3.00 300.00 HLA078 286499539 86501852 ERV_2170923 MSTA,MSTA-int LIL 16.76 44.89 2.68 HLA0782 86500001 86501489 ERV_2170924 MSTA-int I 16.76 44.89 2.68 HLA078 287725211 87730585 ERV_2171742 LTR27D,MER52-int LI 0.77 2.22 2.87 HLA0692 95838110 95838757 ERV_2174448 MSTB,MSTB-int LI 0.00 2.28 300.00 HLA0692 96409606 96409797 ERV_2174746 HERVIP10FH-int I 0.00 1.87 300.00 HLA0532 97751434 97752090 ERV_2175600 MER110-int I 0.00 2.46 300.00 HLA058 21.01E+08 1.01E+08 ERV_2177691 MLT1B,MLT1B-int LI 0.28 2.49 8.99 HLA058 21.02E+08 1.02E+08 ERV_2178182 THE1C,THE1C-int LIL 0.00 2.47 300.00HLA065 2 1.08E+08 1.08E+08 ERV_2181534 ERV3-16A3_I-int I 0.00 3.51300.00 HLA072 2 1.08E+08 1.08E+08 ERV_2181543 ERVL-E-int,LTR33 LI 0.001.90 300.00 HLA058 2 1.08E+08 1.08E+08 ERV_2181629 ERV3-16A3_I-int I0.00 2.01 300.00 HLA072 2 1.09E+08 1.09E+08 ERV_2182084 MLT-int I 0.992.98 3.01 HLA058 2 1.1E+08 1.1E+08 ERV_2182844 ERVL-B4-int,MLT2C1 LI0.99 10.93 11.08 HLA065 2 1.1E+08 1.1E+08 ERV_2182844 ERVL-B4-int,MLT2C1LI 2.07 5.08 2.45 HLA067 2 1.1E+08 1.1E+08 ERV_2182844ERVL-B4-int,MLT2C1 LI 0.95 2.74 2.88 HLA069 2 1.12E+08 1.12E+08ERV_2184003 HERV17-int,LTR17 LIL 8.86 20.02 2.26 HLA076 2 1.12E+081.12E+08 ERV_2184003 HERV17-int,LTR17 LIL 5.91 14.56 2.47 HLA071 21.13E+08 1.13E+O8 ERV_2184406 ERV3-16A3_I-int I 0.52 6.01 11.52 HLA076 21.13E+08 1.13E+O8 ERV_2185042 MER57-int I 0.00 3.74 300.00 HLA065 21.14E+08 1.14E+08 ERV_2185119 ERVL-B4-int I 0.00 1.63 300.00 HLA073 21.17E+08 1.17E+08 ERV_2187017 THE1D-int I 0.00 2.00 300.00 HLA066 21.22E+08 1.22E+08 ERV_2190813 THE1-int I 0.00 2.41 300.00 HLA082 21.26E+08 1.26E+08 ERV_2192784 THE1-int I 0.00 1.79 300.00 HLA069 21.3E+08 1.3E+08 ERV_2195123 MSTA,MSTA-int LIL 0.00 2.02 300.00 HLA069 21.3E+08 1.3E+08 ERV_2195124 THE1D-int I 0.00 2.02 300.00 HLA069 21.3E+08 1.3E+08 ERV_2195125 MSTA,MSTA-int LIL 0.00 2.02 300.00 HLA069 21.3E+08 1.3E+08 ERV_2195127 MSTA,MSTA-int LI 0.00 1.58 300.00 HLA072 21.3E+08 1.3E+08 ERV_2195127 MSTA,MSTA-int LI 0.00 1.91 300.00 HLA082 21.3E+08 1.3E+08 ERV_2195127 MSTA,MSTA-int LI 0.00 1.65 300.00 HLA058 21.3E+08 1.3E+08 ERV_2195130 MER4-int I 0.00 4.24 300.00 HLA058 2 1.3E+081.3E+08 ERV_2195346 MER4-int I 0.00 1.73 300.00 HLA058 2 1.31E+081.31E+08 ERV_2195901 MST-int I 0.00 2.83 300.00 HLA058 2 1.32E+081.32E+08 ERV_2196151 ERV3-16A3_I-int I 0.83 9.17 11.09 HLA069 2 1.35E+081.35E+08 ERV_2197824 HERV9-int I 0.00 1.54 300.00 HLA053 2 1.35E+081.35E+08 ERV_2197879 MLT1F,MLT1F-int LIL 0.66 8.10 12.21 HLA067 21.35E+08 1.35E+08 ERV_2197879 MLT1F,MLT1F-int LIL 1.63 12.71 7.81 HLA0712 1.35E+08 1.35E+08 ERV_2197879 MLT1F,MLT1F-int LIL 5.50 11.00 2.00HLA076 2 1.35E+08 1.35E+08 ERV_2197879 MLT1F,MLT1F-int LIL 4.44 10.722.41 HLA063 2 1.36E+08 1.36E+08 ERV_2198524 MER57A-int I 0.00 1.97300.00 HLA061 2 1.37E+08 1.37E+08 ERV_2199370 MLT1J2,MLT1J2-int LIL 0.001.62 300.00 HLA065 2 1.38E+08 1.38E+08 ERV_2200163 THE1D,THE1D-int LI0.56 2.81 5.00 HLA072 2 1.38E+08 1.38E+08 ERV_2200163 THE1D,THE1D-int LI0.72 5.99 8.26 HLA058 2 1.4E+08 1.4E+08 ERV_2200826 LOR1-int I 0.00 1.76384.70 HLA058 2 1.4E+08 1.4E+08 ERV_2200827 LTR57-int I 0.00 1.76 384.70HLA053 2 1.43E+08 1.43E+08 ERV_2202308 HERVH48-int,MER48 LIL 1.52 5.003.30 HLA067 2 1.43E+08 1.43E+08 ERV_2202308 HERVH48-int,MER48 LIL 0.614.94 8.08 HLA065 2 1.43E+08 1.43E+08 ERV_2202309 MER57-int,MER57B1 LIL0.68 4.30 6.35 HLA067 2 1.43E+08 1.43E+08 ERV_2202309 MER57-int,MER57B1LIL 1.65 4.36 2.63 HLA067 2 1.5E+08 1.5E+08 ERV_2206205ERV3-16A3_I-int,LTR16 LI 0.48 1.57 3.27 HLA073 2 1.51E+08 1.51E+08ERV_2206706 LTR57-int I 1.98 9.92 5.00 HLA073 2 1.51E+08 1.51E+08ERV_2206707 MER65-int I 1.98 9.92 5.00 HLA053 2 1.61E+08 1.61E+08ERV_2212182 MLT1A1,MLT1A1-int LI 0.58 2.09 3.58 HLA066 2 1.62E+081.62E+08 ERV_2212769 MLT1B,MLT1B-int LI 3.00 7.51 2.50 HLA072 2 1.62E+081.62E+08 ERV_2212769 MLT1B,MLT1B-int LI 3.59 8.34 2.32 HLA073 2 1.62E+081.62E+08 ERV_2212769 MLT1B,MLT1B-int LI 2.24 5.70 2.54 HLA066 2 1.62E+081.62E+08 ERV_2212771 MLT1-int I 3.00 7.51 2.50 HLA072 2 1.62E+081.62E+08 ERV_2212771 MLT1-int I 3.59 8.34 2.32 HLA073 2 1.62E+081.62E+08 ERV_2212771 MLT1-int I 2.24 5.70 2.54 HLA067 2 1.65E+081.65E+08 ERV_2213915 HERV17-int,LTR17 LI 0.34 1.77 5.27 HLA076 21.65E+08 1.65E+08 ERV_2213915 HERV17-int,LTR17 LI 0.07 1.89 26.94 HLA0582 1.66E+08 1.66E+08 ERV_2214571 THE1B,THE1B-int LIL 0.00 1.53 300.00HLA058 2 1.67E+08 1.67E+08 ERV_2215318 MamGyp-int,MamGypLTR1c LI 0.071.83 26.52 HLA058 2 1.68E+08 1.68E+08 ERV_2215422 MLTIJ-int I 0.00 2.13300.00 HLA067 2 1.69E+08 1.69E+08 ERV_2216221 THE1D,THE1D-int LIL 8.1522.45 2.75 HLA069 2 1.69E+08 1.69E+08 ERV_2216221 THE1D,THE1D-int LIL0.27 2.22 8.23 HLA058 2 1.7E+08 1.7E+08 ERV_2216651 THE1A,THE1A-int LIL14.3 7 31.54 2.19 HLA082 2 1.7E+08 1.7E+08 ERV_2216651 THE1A,THE1A-intLIL 9.65 24.87 2.58 HLA058 2 1.7E+08 1.7E+08 ERV_2216668HERVL18-int,LTR18B LIL 0.00 16.17 300.00 HLA072 2 1.7E+08 1.7E+08ERV_2216668 HERVL18-int,LTR18B LIL 0.05 1.61 32.10 HLA061 2 1.71E+081.71E+08 ERV_2217362 HERVK11D-int,MER11D LIL 0.09 2.62 27.63 HLA063 21.71E+08 1.71E+08 ERV_2217362 HERVK11D-int,MER11D LIL 0.07 4.03 56.71HLA071 2 1.71E+08 1.71E+08 ERV_2217362 HERVK11D-int,MER11D LIL 0.19 2.9615.71 HLA082 2 1.74E+08 1.74E+08 ERV_2220021 THE1B,THE1B-int LIL 0.172.23 13.13 HLA069 2 1.75E+08 1.75E+08 ERV_2220286 LTR49-int I 0.00 4.39300.00 HLA067 2 1.83E+08 1.83E+08 ERV_2224792 MLT1E2,MLT1E2-int LI 0.011.52 143.63 HLA072 2 1.83E+08 1.83E+08 ERV_2224792 MLT1E2,MLT1E2-int LI0.00 1.56 300.00 HLA067 2 1.87E+08 1.87E+08 ERV_2226945 THE1B,THE1B-intLI 0.00 2.70 300.00 HLA067 2 1.88E+08 1.88E+08 ERV_2226967HERVH-int,LTR7 LIL 0.68 3.31 4.85 HLA072 2 1.91E+08 1.91E+08 ERV_2228579PABL_A,PABL_A-int LI 0.07 1.54 23.40 HLA069 2 1.91E+08 1.91E+08ERV_2229108 HERVH-int,LTR7B LI 0.01 2.18 190.28 HLA082 2 1.91E+081.91E+08 ERV_2229108 HERVH-int,LTR7B LI 0.88 2.68 3.04 HLA071 2 1.94E+081.94E+08 ERV_2230157 MER61-int,MER61A LI 0.01 1.65 206.31 HLA076 2 2E+082E+08 ERV_2233678 LTR37-int I 0.09 2.18 24.33 HLA067 2 2.01E+08 2.01E+08ERV_2234623 MER76,MER76-int LI 0.91 2.57 2.83 HLA071 2 2.01E+08 2.01E+08ERV_2234623 MER76,MER76-int LI 0.61 4.40 7.18 HLA061 2 2.1E+08 2.1E+08ERV_2240288 MER4B-int I 0.00 2.18 300.00 HLA066 2 2.1E+08 2.1E+08ERV_2240288 MER4B-int I 0.00 2.34 300.00 HLA063 2 2.1E+08 2.1E+08ERV_2240582 MLT1C,MLT1C-int LI 0.62 2.95 4.73 HLA065 2 2.1E+08 2.1E+08ERV_2240582 MLT1C,MLT1C-int LI 2.06 7.14 3.46 HLA072 2 2.1E+08 2.1E+08ERV_2240582 MLT1C,MLT1C-int LI 1.07 2.82 2.62 HLA073 2 2.1E+08 2.1E+08ERV_2240582 MLT1C,MLT1C-int LI 0.94 2.27 2.41 HLA078 2 2.1E+08 2.1E+08ERV_2240582 MLT1C,MLT1C-int LI 0.23 2.00 8.71 HLA071 2 2.11E+08 2.11E+08ERV_2240827 THE1C,THE1C-int LIL 0.40 4.54 11.36 HLA073 2 2.16E+082.16E+08 ERV_2243717 ERV3-16A3_I-int,LTR16A LI 0.38 1.82 4.77 HLA076 22.16E+08 2.16E+08 ERV_2243717 ERV3-16A3_I-int,LTR16A LI 0.62 1.53 2.48HLA067 2 2.16E+08 2.16E+08 ERV_2243795 HERVK14-int I 0.00 1.66 300.00HLA071 2 2.16E+08 2.16E+08 ERV_2243795 HERVK14-int I 1.25 2.85 2.27HLA076 2 2.16E+08 2.16E+08 ERV_2243795 HERVK14-int I 0.00 1.94 300.00HLA063 2 2.16E+08 2.16E+08 ERV_2243896 LOR1-int I 3.44 7.59 2.21 HLA0652 2.16E+08 2.16E+08 ERV_2243896 LOR1-int I 1.74 8.10 4.66 HLA072 22.16E+08 2.16E+08 ERV_2243896 LOR1-int I 3.88 11.89 3.07 HLA076 22.16E+08 2.16E+08 ERV_2243896 LOR1-int I 3.88 7.93 2.04 HLA082 22.16E+08 2.16E+08 ERV_2243896 LOR1-int I 4.09 12.95 3.16 HLA072 22.16E+08 2.16E+08 ERV_2243897 MER101-int I 1.62 3.62 2.23 HLA082 22.16E+08 2.16E+08 ERV_2243897 MER101-int I 0.78 4.64 5.97 HLA072 22.16E+08 2.16E+08 ERV_2243898 LOR1-int I 1.62 3.62 2.23 HLA082 22.16E+08 2.16E+08 ERV_2243898 LOR1-int I 0.78 4.64 5.97 HLA072 22.16E+08 2.16E+08 ERV_2243899 LTR57-int I 1.62 3.62 2.23 HLA082 22.16E+08 2.16E+08 ERV_2243899 LTR57-int I 0.78 4.64 5.97 HLA072 22.19E+08 2.19E+08 ERV_2245866 MER41E,MER66-int LI 0.82 1.97 2.40 HLA0672 2.19E+08 2.19E+08 ERV_2245878 MER57-int,MER57B1 LI 0.42 1.72 4.07HLA067 2 2.19E+08 2.19E+08 ERV_2245883 MER61-int,MER61B LI 0.43 1.663.90 HLA071 2 2.19E+08 2.19E+08 ERV_2245883 MER61-int,MER61B LI 0.832.61 3.15 HLA065 2 2.19E+08 2.19E+08 ERV_2246273 ERV3-16A3_I-int I 0.002.00 300.00 HLA066 2 2.19E+08 2.19E+08 ERV_2246273 ERV3-16A3_I-int I1.99 8.03 4.03 HLA076 2 2.19E+08 2.19E+08 ERV_2246273 ERV3-16A3_I-int I3.31 10.53 3.18 HLA082 2 2.19E+08 2.19E+08 ERV_2246273 ERV3-16A3_I-int I0.97 3.13 3.23 HLA065 2 2.3E+08 2.3E+08 ERV_2253045 MER101-int I 0.021.84 75.64 HLA065 2 2.3E+08 2.3E+08 ERV_2253176 ERV3-16A3_I-int I 0.001.80 300.00 HLA063 2 2.31E+08 2.31E+08 ERV_2253347 LTR49-int I 0.63 2.203.51 HLA076 2 2.31E+08 2.31E+08 ERV_2253370 MSTA,MSTA-int LIL 0.87 2.883.33 HLA063 2 2.33E+08 2.33E+08 ERV_2254973 ERVL-B4-int I 6.69 13.822.07 HLA066 2 2.33E+08 2.33E+08 ERV_2254973 ERVL-B4-int I 3.21 13.144.09 HLA073 2 2.33E+08 2.33E+08 ERV_2254973 ERVL-B4-int I 1.40 6.51 4.67HLA076 2 2.33E+08 2.33E+08 ERV_2254973 ERVL-B4-int I 6.55 15.35 2.34HLA065 2 2.33E+08 2.33E+08 ERV_2255245 ERVL-E-int I 0.00 6.88 300.00HLA067 2 2.33E+08 2.33E+08 ERV_2255245 ERVL-E-int I 0.32 2.74 8.61HLA072 2 2.33E+08 2.33E+08 ERV_2255245 ERVL-E-int I 1.11 2.69 2.42HLA082 2 2.33E+08 2.33E+08 ERV_2255245 ERVL-E-int I 0.00 1.89 300.00HLA065 2 2.33E+08 2.33E+08 ERV_2255251 ERVL-B4-int I 1.40 3.56 2.54HLA065 2 2.33E+08 2.33E+08 ERV_2255279 MLT1A0,MLT1A0-int LIL 1.18 2.672.27 HLA072 2 2.33E+08 2.33E+08 ERV_2255279 MLT1A0,MLT1A0-int LIL 0.342.17 6.34 HLA061 2 2.41E+08 2.41E+08 ERV_2259829 MLT1J-int I 0.00 2.76300.00 HLA065 2 2.41E+08 2.41E+08 ERV_2259955 ERVL-E-int I 0.00 1.96300.00 HLA067 2 2.41E+08 2.41E+08 ERV_2259955 ERVL-E-int I 0.63 7.6712.22 HLA071 2 2.41E+08 2.41E+08 ERV_2259955 ERVL-E-int I 0.49 1.82 3.72HLA072 2 2.41E+08 2.41E+08 ERV_2259955 ERVL-E-int I 0.00 2.22 300.00HLA063 2 2.41E+08 2.41E+08 ERV_2259957 ERVL-E-int I 2.79 6.63 2.38HLA066 2 2.41E+08 2.41E+08 ERV_2259957 ERVL-E-int I 0.66 3.51 5.32HLA067 2 2.41E+08 2.41E+08 ERV_2259957 ERVL-E-int I 11.5 6 25.67 2.22HLA069 2 2.41E+08 2.41E+08 ERV_2259957 ERVL-E-int I 0.73 5.29 7.26HLA072 2 2.41E+08 2.41E+08 ERV_2259957 ERVL-E-int I 1.51 9.18 6.07HLA067 2 2.42E+08 2.42E+08 ERV_2260518 PRIMA4-int,PRIMA4_LTR LI 0.122.62 22.29 HLA069 2 2.42E+08 2.42E+08 ERV_2260691 MER31-int I 0.61 1.582.58 HLA082 2 2.42E+08 2.42E+08 ERV_2260692 MER34B-int,MER34C_ LI 0.553.20 5.76 HLA065 20 44037742 44038081 ERV_2300711 THE1D,THE1D-int LI0.00 2.00 300.00 HLA067 20 18313019 18313139 ERV_2335472 LTR37-int I0.00 4.13 300.00 HLA063 20 30412172 30412388 ERV_2340811 MER57-int I0.77 2.50 3.25 HLA067 22 11923323 11923379 ERV_2423890 THE1D-int I 0.001.66 300.00 HLA063 22 36215797 36215947 ERV_2445987 PRIMA4-int I 0.292.00 6.98 HLA058 22 47787334 47787754 ERV_2459028 THE1D-int I 0.00 2.80300.00 HLA065 3 861491 861718 ERV_2490988 HERVE_a-int I 1.97 4.27 2.17HLA082 3 8647481 8647600 ERV_2498025 ERVL-B4-int I 0.00 1.75 300.00HLA063 3 11812212 11812318 ERV_2501713 HERV16-int I 1.49 6.88 4.61HLA069 3 11812212 11812318 ERV_2501713 HERV16-int I 0.00 1.59 300.00HLA072 3 11812212 11812318 ERV_2501713 HERV16-int I 1.39 3.05 2.20HLA082 3 11812212 11812318 ERV_2501713 HERV16-int I 1.44 3.50 2.42HLA069 3 11812373 11813017 ERV_2501714 ERV3-16A3_I-int I 0.00 1.72300.00 HLA072 3 11812373 11813017 ERV_2501714 ERV3-16A3_I-int I 0.653.49 5.38 HLA082 3 11812373 11813017 ERV_2501714 ERV3-16A3_I-int I 0.581.69 2.94 HLA082 3 32469211 32469367 ERV_2520070 ERV3-16A3_I-int I 0.621.71 2.74 HLA069 3 36985489 36986389 ERV_2524084 MLT1I,MLT1I-int LI 0.322.22 6.85 HLA072 3 36985489 36986389 ERV_2524084 MLT1I,MLT1I-int LI 1.033.01 2.91 HLA082 3 36985489 36986389 ERV_2524084 MLT1I,MLT1I-int LI 0.691.68 2.45 HLA065 3 37380152 37380435 ERV_2524480 MLT1H-int I 0.07 4.9970.55 HLA065 3 38417327 38417585 ERV_2525275 MLT1H-int I 33.64 69.382.06 HLA067 3 38420760 38427256 ERV_2525282 HERVK9-int,MER9B LIL 8.6029.33 3.41 HLA065 3 38451965 38452175 ERV_2525297 ERVL-E-int I 0.58 5.579.66 HLA071 3 38451965 38452175 ERV_2525297 ERVL-E-int I 0.63 8.50 13.43HLA072 3 39421775 39422013 ERV_2526146 MLT1J-int I 0.00 4.30 300.00HLA061 3 39788550 39789234 ERV_2526446 MLT1H,MLT1H-int LI 0.00 3.20300.00 HLA071 3 39788550 39789234 ERV_2526446 MLT1H,MLT1H-int LI 1.006.70 6.72 HLA073 3 39788550 39789234 ERV_2526446 MLT1H,MLT1H-int LI 0.002.29 300.00 HLA076 3 39788550 39789234 ERV_2526446 MLT1H,MLT1H-int LI0.00 9.04 300.00 HLA071 3 39794777 39794897 ERV_2526450 MER89-int I 0.143.10 21.60 HLA076 3 39794777 39794897 ERV_2526450 MER89-int I 0.30 2.588.75 HLA071 3 40262923 40264376 ERV_2526760 MER31-int,MER31B LI 1.323.25 2.47 HLA071 3 40263670 40263767 ERV_2526763 MER34B-int I 1.32 3.252.47 HLA063 3 40264428 40265037 ERV_2526765 MER101-int I 1.30 2.99 2.30HLA071 3 40264428 40265037 ERV_2526765 MER101-int I 0.40 2.21 5.58HLA065 3 40489918 40490509 ERV_2527012 MSTD,MSTD-int LI 5.41 14.54 2.69HLA066 3 40489918 40490509 ERV_2527012 MSTD,MSTD-int LI 6.41 15.49 2.42HLA071 3 40489918 40490509 ERV_2527012 MSTD,MSTD-int LI 6.37 22.94 3.60HLA065 3 41683025 41685909 ERV_2527968 HERV351-int,LTR35,LTR35A LIL 0.302.37 8.03 HLA069 3 42896033 42900433 ERV_2529208 MER50-int,MER50C LI0.99 8.00 8.10 HLA073 3 42896033 42900433 ERV_2529208 MER50-int,MER50CLI 1.36 3.77 2.78 HLA073 3 44425387 44425473 ERV_2530470 MER89-int I0.92 2.06 2.24 HLA065 3 44493044 44494098 ERV_2530539 MLT-int I 3.257.58 2.33 HLA069 3 44750216 44751991 ERV_2530766 LOR1-int I 15.55 34.072.19 HLA071 3 44750216 44751991 ERV_2530766 LOR1-int I 26.74 93.89 3.51HLA061 3 47175379 47175910 ERV_2533028 MSTA,MSTA-int LI 0.44 2.41 5.53HLA063 3 47175379 47175910 ERV_2533028 MSTA,MSTA-int LI 0.21 1.54 7.32HLA066 3 47175379 47175910 ERV_2533028 MSTA,MSTA-int LI 0.00 4.26 300.00HLA072 3 47175379 47175910 ERV_2533028 MSTA,MSTA-int LI 0.00 6.52 300.00HLA072 3 47176108 47178714 ERV_2533029 MER57A-int I 0.56 3.53 6.36HLA072 3 48282075 48283201 ERV_2534510 ERVL-E-int,LTR16E2 LI 0.00 1.53300.00 HLA063 3 50584334 50584921 ERV_2536895 MLT1D,MLT1D-int LI 9.1928.40 3.09 HLA072 3 60051427 60052420 ERV_2545650 MER66-int,MER66B LI0.00 2.83 300.00 HLA069 3 63851897 63852287 ERV_2549412 MST-int I 0.001.69 300.00 HLA061 3 75624158 75624604 ERV_2560894 MER31-int I 0.00 3.43300.00 HLA061 3 75625169 75625901 ERV_2560895 MER92-int I 0.52 1.89 3.62HLA065 3 93938055 93944071 ERV_2572887 HERVH-int,LTR7 LIL 0.43 1.78 4.12HLA065 3 93961783 93969033 ERV_2572903 ERVL-E-int I 0.68 2.32 3.42HLA066 3 1E+08 1E+08 ERV_2577538 MLT1J-int I 0.46 1.98 4.27 HLA071 31E+08 1E+08 ERV_2577538 MLT1J-int I 0.72 1.93 2.67 HLA071 3 1E+08 1E+08ERV_2577667 MLT1-int I 0.84 3.89 4.62 HLA071 3 1E+08 1E+08 ERV_2577668MLT-int I 0.84 3.89 4.62 HLA072 3 1.02E+08 1.02E+08 ERV_2578677HERVK-int,LTR5_Hs LIL 4.89 10.78 2.20 HLA073 3 1.02E+08 1.02E+08ERV_2578677 HERVK-int,LTR5_Hs LIL 4.98 11.32 2.27 HLA065 3 1.05E+081.05E+08 ERV_2581505 ERVL-E-int I 0.00 2.59 300.00 HLA072 3 1.05E+081.05E+08 ERV_2581505 ERVL-E-int I 0.51 2.13 4.20 HLA061 3 1.13E+081.13E+08 ERV_2587430 HERVL-int,MLT2A1 LI 0.78 3.39 4.36 HLA065 31.13E+08 1.13E+08 ERV_2587918 THE1A,THE1A-int LIL 0.00 2.37 300.00HLA072 3 1.13E+08 1.13E+08 ERV_2587918 THE1A,THE1A-int LIL 0.07 2.9344.96 HLA063 3 1.21E+08 1.21E+08 ERV_2594376 MER4B-int,MER4D1 LIL 13.5728.83 2.12 HLA065 3 1.21E+08 1.21E+08 ERV_2594376 MER4B-int,MER4D1 LIL1.72 11.62 6.75 HLA066 3 1.22E+08 1.22E+08 ERV_2595570 THE1C,THE1C-intLI 0.00 3.75 300.00 HLA061 3 1.23E+08 1.23E+08 ERV_2595957 MLT1J-int I3.88 7.86 2.03 HLA065 3 1.23E+08 1.23E+08 ERV_2595957 MLT1J-int I 2.718.49 3.13 HLA066 3 1.23E+08 1.23E+08 ERV_2595957 MLT1J-int I 6.58 17.962.73 HLA065 3 1.26E+08 1.26E+08 ERV_2599024 HERVL-int,MLT2A2 LI 0.561.92 3.42 HLA073 3 1.26E+08 1.26E+08 ERV_2599429 MER4B-int,MER4E LI 4.7313.73 2.90 HLA076 3 1.26E+08 1.26E+08 ERV_2599499 LTR25-int I 0.34 2.467.14 HLA076 3 1.26E+08 1.26E+08 ERV_2599500 HERVFH19-int,LTR19B LI 0.342.46 7.14 HLA061 3 1.26E+08 1.26E+08 ERV_2599552 HERVH-int,LTR7C LI 0.202.30 11.35 HLA076 3 1.26E+08 1.26E+08 ERV_2599552 HERVH-int,LTR7C LI0.25 6.61 26.70 HLA066 3 1.28E+08 1.28E+08 ERV_2601368 MLT1C,MLT1C-intLI 0.00 1.57 300.00 HLA065 3 1.29E+08 1.29E+08 ERV_2601873THE1B,THE1B-int LIL 3.60 7.29 2.03 HLA065 3 1.31E+08 1.31E+08ERV_2604096 HERV4_I-int,MER51E LI 0.48 1.85 3.87 HLA065 3 1.36E+081.36E+08 ERV_2608801 HERV16-int I 0.00 6.90 300.00 HLA066 3 1.41E+081.41E+08 ERV_2612781 ERVL-B4-int I 0.00 2.93 300.00 HLA066 3 1.43E+081.43E+08 ERV_2614808 MLT1O,MLT1O-int LI 0.06 6.56 105.79 HLA076 31.43E+08 1.43E+08 ERV_2614808 MLT1O,MLT1O-int LI 0.00 6.22 300.00 HLA0653 1.47E+08 1.47E+08 ERV_2617661 MLT1A,MLT1A-int LI 4.58 9.61 2.10 HLA0653 1.47E+08 1.47E+08 ERV_2617662 MLT1A-int I 0.96 7.89 8.19 HLA065 31.57E+08 1.57E+08 ERV_2626701 MLT1I,MLT1I-int LI 0.00 2.45 300.00 HLA0653 1.79E+08 1.79E+08 ERV_2644692 LTR49,LTR49-int LIL 0.32 1.69 5.32HLA065 3 1.79E+08 1.79E+08 ERV_2644693 MER34-int I 0.32 1.69 5.32 HLA0653 1.79E+08 1.79E+08 ERV_2644697 MER4B-int I 0.32 1.69 5.32 HLA065 31.89E+08 1.89E+08 ERV_2654773 MLT1K-int I 1.16 4.88 4.21 HLA076 31.89E+08 1.89E+08 ERV_2655007 ERVL-E-int I 0.42 2.05 4.85 HLA065 31.95E+08 1.95E+08 ERV_2660642 THE1D,THE1D-int LIL 0.73 2.27 3.11 HLA0653 1.96E+08 1.96E+08 ERV_2661061 MER4-int,MER4A1 LI 2.16 8.31 3.84 HLA0653 1.96E+08 1.96E+08 ERV_2661062 MER4-int I 3.62 15.79 4.36 HLA072 38951757 8952322 ERV_2669662 MLT1A,MLT1A-int LI 0.00 1.67 300.00 HLA066 324355876 24356722 ERV_2680511 MLT-int I 0.35 1.92 5.47 HLA066 3 2435645924356557 ERV_2680512 MLT1F-int I 0.35 1.92 5.47 HLA072 3 3246093932466915 ERV_2685671 HERVH-int,LTR7 LIL 0.52 1.54 2.95 HLA071 3 3979256339795951 ERV_2690420 MER89,MER89-int LIL 0.14 3.10 21.60 HLA076 339792563 39795951 ERV_2690420 MER89,MER89-int LIL 0.30 2.58 8.75 HLA0653 39843529 39845079 ERV_2690449 ERVL-E-int I 0.00 2.80 300.00 HLA069 342918197 42924975 ERV_2692477 LTR25-int,MER61D LI 0.65 1.60 2.47 HLA0693 42924026 42924859 ERV_2692480 MER61-int I 0.65 1.60 2.47 HLA065 344344658 44351310 ERV_2693392 HERVH-int,LTR7 LI 0.67 1.57 2.34 HLA065 344432310 44439444 ERV_2693437 ERVL-B4-int,MLT2B4 LI 1.87 5.29 2.82HLA072 3 44432310 44439444 ERV_2693437 ERVL-B4-int,MLT2B4 LI 3.71 10.502.83 HLA065 3 44437398 44438010 ERV_2693443 MER41C,PRIMA41-int LIL 1.875.29 2.82 HLA072 3 44437398 44438010 ERV_2693443 MER41C,PRIMA41-int LIL3.71 10.50 2.83 HLA061 3 44482590 44492743 ERV_2693473 MER70-int,MER70CLI 1.81 4.42 2.44 HLA072 3 44482590 44492743 ERV_2693473MER70-int,MER70C LI 1.68 3.83 2.27 HLA072 3 46417276 46417895ERV_2694938 HERVL18-int,LTR18A LI 0.79 5.02 6.39 HLA061 3 4682894546829022 ERV_2695182 MLT1J-int I 0.58 3.92 6.71 HLA063 3 4682894546829022 ERV_2695182 MLT1J-int I 0.00 1.88 300.00 HLA072 3 4718579347187326 ERV_2695395 HERV16-int I 0.30 1.57 5.26 HLA071 3 5236361752364198 ERV_2699363 MLT1K,MLT1K-int LI 0.58 1.71 2.95 HLA063 3 5754953457550026 ERV_2702721 MER57A-int I 0.49 1.79 3.65 HLA072 3 5754953457550026 ERV_2702721 MER57A-int I 0.28 1.76 6.28 HLA061 3 5755034157552448 ERV_2702723 MER57A-int I 0.55 1.81 3.27 HLA061 3 5755243857553637 ERV_2702728 MER57A-int I 0.55 1.81 3.27 HLA065 3 6899174568994028 ERV_2710761 THE1A,THE1A-int LIL 0.23 2.29 10.09 HLA063 3 1E+081E+08 ERV_2725792 MSTA,MSTA-int LIL 0.30 2.04 6.79 HLA072 3 1.14E+081.14E+08 ERV_2733312 THE1C,THE1C-int LIL 0.47 2.87 6.13 HLA065 31.21E+08 1.21E+08 ERV_2737080 HERVIP10FH-int,LTR10F LIL 0.37 1.78 4.83HLA071 3 1.21E+08 1.21E+08 ERV_2737106 MSTA,MSTA-int LIL 3.81 25.23 6.63HLA076 3 1.21E+08 1.21E+08 ERV_2737106 MSTA,MSTA-int LIL 6.62 17.57 2.65HLA065 3 1.23E+08 1.23E+08 ERV_2738763 ERVL-E-int I 0.00 2.27 300.00HLA065 3 1.24E+08 1.24E+08 ERV_2738987 THE1D,THE1D-int LI 1.11 2.36 2.13HLA071 3 1.24E+08 1.24E+08 ERV_2738987 THE1D,THE1D-int LI 4.17 16.163.88 HLA072 3 1.24E+08 1.24E+08 ERV_2738987 THE1D,THE1D-int LI 0.65 1.672.59 HLA073 3 1.24E+08 1.24E+08 ERV_2738987 THE1D,THE1D-int LI 0.56 4.407.86 HLA065 3 1.26E+08 1.26E+08 ERV_2740512 HERVK-int,LTRSA LI 0.32 2.016.21 HLA072 3 1.26E+08 1.26E+08 ERV_2740512 HERVK-int,LTRSA LI 0.18 3.6720.43 HLA066 3 1.26E+08 1.26E+08 ERV_2740711 MER57A-int,MER57C2 LI 0.221.92 8.65 HLA076 3 1.26E+08 1.26E+08 ERV_2740741 HUERS-P2-int I 0.033.33 122.79 HLA076 3 1.27E+08 1.27E+08 ERV_2740977 LTR52,LTR52-int LI4.37 12.82 2.93 HLA076 3 1.27E+08 1.27E+08 ERV_2740978 LTR52-int I 4.3712.82 2.93 HLA066 3 1.29E+08 1.29E+08 ERV_2743068 THE1A,THE1A-int LIL2.75 6.06 2.20 HLA067 3 1.39E+08 1.39E+08 ERV_2749370 HERVIP10FH-int I0.00 2.00 300.00 HLA063 3 1.46E+08 1.46E+08 ERV_2753989 MLT1D-int I 0.321.84 5.75 HLA065 3 1.46E+08 1.46E+08 ERV_2753989 MLT1D-int I 0.14 4.0328.07 HLA076 3 1.56E+08 1.56E+08 ERV_2759388 MER41E,MER66-int LI 0.812.26 2.80 HLA076 3 1.89E+08 1.89E+08 ERV_2780386 ERVL-E-int I 0.42 2.054.85 HLA065 3 1.91E+08 1.91E+08 ERV_2781142 MER61-int,MER61A,MER61B LIL0.68 4.28 6.27 HLA065 3 1.98E+08 1.98E+08 ERV_2785913 MER4-int,MER4A1 LI2.64 7.73 2.92 HLA065 3 1.98E+08 1.98E+08 ERV_2786124 ERVL-E-int I 4.9011.10 2.27 HLA065 4 174515 175475 ERV_2786516 HERV4_I-int I 0.00 2.02300.00 HLA065 4 476656 477099 ERV_2786754 MER50-int I 0.00 1.67 300.00HLA065 4 980908 982755 ERV_2787126 HERVL74-int I 0.63 2.22 3.53 HLA065 42477152 2479737 ERV_2788260 THE1B,THE1B-int LIL 0.61 1.65 2.72 HLA065 42728490 2730727 ERV_2788485 LTR39-int I 0.92 2.30 2.51 HLA065 4 83584598364122 ERV_2793809 MER41-int,MER41A LIL 0.87 2.49 2.86 HLA076 4 83584598364122 ERV_2793809 MER41-int,MER41A LIL 2.70 9.82 3.64 HLA065 4 83614568363579 ERV_2793811 MER41-int I 0.87 2.49 2.86 HLA076 4 8361456 8363579ERV_2793811 MER41-int I 2.70 9.82 3.64 HLA065 4 9791305 9791937ERV_2795012 MLT1F2,MLT1F2-int LI 1.25 5.23 4.20 HLA065 4 1791485517917663 ERV_2802968 MLT1F1,MLT1F1-int LI 1.37 7.85 5.72 HLA065 423764968 23766385 ERV_2808448 MLT1L,MLT1L-int LI 1.50 11.96 7.98 HLA0584 1.23E+08 1.23E+08 ERV_2890471 ERVL-E-int I 0.00 1.66 300.00 HLA061 41.23E+08 1.23E+08 ERV_2890471 ERVL-E-int I 0.00 1.93 300.00 HLA065 4491737 498501 ERV_2945944 MER4-int,MER4A1 LI 1.05 2.89 2.75 HLA065 4496166 497422 ERV_2945948 PRIMA4-int I 1.05 2.89 2.75 HLA065 4 16908951691651 ERV_2946462 MLT1F-int I 0.00 2.27 300.00 HLA065 4 66797676680232 ERV_2950166 MamGyp-int I 0.69 1.78 2.59 HLA065 4 2375986923760755 ERV_2961152 THE1B,THE1B-int LI 0.19 2.30 12.21 HLA071 434178068 34180422 ERV_2967337 MamGyp-int I 0.30 2.09 6.95 HLA071 51824816 1825059 ERV_3053759 ERVL-E-int I 0.00 2.11 300.00 HLA058 518731989 18732283 ERV_3066933 ERV3-16A3_I-int I 0.49 2.69 5.46 HLA058 528911600 28913194 ERV_3075518 MSTB,MSTB-int LIL 0.00 1.50 300.00 HLA0635 1.19E+08 1.19E+08 ERV_3146773 MLT1-int I 0.00 2.00 300.00 HLA053 51.6E+08 1.6E+08 ERV_3184264 ERVL-E-int I 0.00 3.00 300.00 HLA061 51.6E+08 1.6E+08 ERV_3184264 ERVL-E-int I 0.00 2.00 300.00 HLA072 580135391 80135557 ERV_3248382 MLT1H-int I 0.00 2.50 300.00 HLA072 51.29E+08 1.29E+08 ERV_3274286 PRIMA4-int I 0.00 2.00 300.00 HLA071 51.46E+08 1.46E+08 ERV_3285587 PRIMA4-int I 0.47 2.58 5.47 HLA072 629736067 29736195 ERV_3331421 ERVL-E-int I 1.49 4.00 2.68 HLA072 61.09E+08 1.09E+08 ERV_3376476 LTR37-int I 0.20 1.51 7.40 HLA067 635700080 35700151 ERV_3444673 MLT1H-int I 0.00 2.00 300.00 HLA067 767292254 67292308 ERV_3611239 MER70-int I 1.00 3.15 3.15 HLA065 775320503 75320629 ERV_3621168 MER84-int I 0.00 2.17 300.00 HLA082 792486794 92486920 ERV_3635952 MLTIJ-int I 0.00 1.67 300.00 HLA078 71.46E+08 1.46E+08 ERV_3683626 MLT1J2,MLT1J2-int LI 0.00 2.20 300.00HLA069 7 29410698 29410844 ERV_3712658 MER4-int I 0.00 1.60 300.00HLA058 7 39660894 39663183 ERV_3718999 THE1B,THE1B-int LIL 0.01 1.71186.86 HLA067 7 73156078 73156138 ERV_3738996 PRIMA4-int I 0.00 2.00300.00 HLA065 7 1.21E+08 1.21E+08 ERV_3769128 MER57A-int I 0.00 4.71300.00 HLA063 7 1.57E+08 1.57E+08 ERV_3791405 ERVL-B4-int I 0.00 1.52300.00 HLA061 8 1.26E+08 1.26E+08 ERV_3900344 ERVL-E-int I 0.43 1.583.67 HLA066 8 1.41E+08 1.41E+08 ERV_3915441 ERVL-E-int I 0.25 2.21 9.01HLA065 8 12732389 12732421 ERV_3926223 HUERS-P3-int I 0.00 3.00 300.00HLA063 8 60397280 60397864 ERV_3954233 ERV3-16A3_I-int I 0.00 1.53300.00 HLA053 8 1.3E+08 1.3E+08 ERV_3997466 MER21-int I 0.00 2.00 300.00HLA061 9 1.12E+08 1.12E+08 ERV_4089269 MER4-int I 0.77 2.00 2.59 HLA0739 1.37E+08 1.37E+08 ERV_4116210 MER101-int I 0.00 2.00 300.00 HLA072 935831502 35831706 ERV_4137812 ERVL-B4-int I 0.00 1.96 300.00 HLA053 X27677766 27677862 ERV_4223114 ERVL-E-int I 0.00 3.00 300.00 HLA073 X1.54E+08 1.54E+08 ERV_4320593 MLT1-int I 0.00 2.00 300.00 HLA082 X1.54E+08 1.54E+08 ERV_4320593 MLT1-int I 0.00 1.58 300.00 HLA082 X68836462 68836528 ERV_4364403 MamGyp-int I 0.00 1.67 300.00 HLA065 X71784021 71784077 ERV_4366533 HERVK11-int I 0.00 2.00 300.00 SAMPLE =sample code; CHROM = chromosome; START = start nucleotide position onchromosome; STOP = stop nucleotide position on chromosome; ID = ERVidentification number; NAME = ERV type name; Subtype = region in the ERVsequence; NT = expression level in non-tumor tissues; T = expressionlevel in tumor tissues; ratio T vs. NT = ratio between expression levelin tumor vs. non-tumor tissues.

The over-expressed sequences in more than 50% of the analyzed samplesare shown in Table 2 and were selected to identify specific internalgene sequences of HERVs.

TABLE 2 Expression of individual ERVs in the liver cancer samples. IDHLA053 HLA 058 HLA 061 HLA 063 HLA 065 HLA 066 HLA 067 HLA 069 HLA071HLA 072 HLA 073 HLA076 HLA078 HLA0 82 ERV_0312447 X X X X X X X XERV_0312445 X X X X X X X X ERV_0127104 X X X X X X X X ERV_0168088 X XX X X X X ERV_0168090 X X X X X X X ERV_0227869 X X X X X X X XERV_0300843 X X X X X X X X ERV_0308616 X X X X X X X X ERV_2093181 X XX X X X X X

Protein Sequences of HERVs Genes

The nucleotide sequences of the HERVd database in Table 2 weretranslated and aligned with Blast to identify specific retroviralopen-reading frames (ORF), that is, to verify the specific identity ofthe HERV proteins. In the vast majority of cases such ORFs have not beenidentified. Only for three sequences (ID: ERV_0312447, ERV_0312445,having SEQ ID NO: 1 and ERV_0308616, having SEQ ID NO: 2) ORFscorresponding to retroviral proteins were identified, in particularthese sequences were found to be corresponding to genes of the HERV-K.In particular, the sequences ERV 0312447, ERV_0312445 were found to beidentical to each other and identical (100% homology) with the Polsequence of member 7 of the HERV-K (aa 85-1459) and have sequence:

MLTDLRAVNAVIQPMGPLQPGLPSPAMIPKDWPLIIIDLKDCFFTIPLAEQDCEKFAFTIPAINNKEPATRFQWKVLPQGMLNSPTICQTFVGRALQPVREKFSDCYIIHYIDDILCAAETRDKLIDCYTFLQAEVANAGLAIASDKIQTSTPFHYLGMQIENRKIKQQKIEIRKDTLKTLNDFQKLLGDINWIRPTLGIPTYAMSNLFSILRGDSDLNSKRILTPEATKEIKLVEEKIQSAQINRIDPLAPLQLLIFATAHSPTGIIIQNTDLVEWSFLPHSTVKTFTLYLDQIATLIGQTRLRIIKLCGNDPDKIVVPLTKEQVRQAFINSGAWQIGLANFVGIIDNHYPKTKIFQFLKLTTWILPKITRREPLENALTVFTDGSSNGKAAYTGPKERVIKTPYQSAQRAELVAVITVLQDFDQPINIISDSAYVVQATRDVETALIKYSMDDQLNQLFNLLQQTVRKRNFPFYITHIRAHTNLPGPLTKANEQADLLVSSALIKAQELHALTHVNAAGLKNKFDVTWKQAKDIVQHCTQCQILHLPTQEAGVNPRGLCPNALWQMDVTHVPSFGRLSYVHVTVDTYSHFIWATCQTGESTSHVKKHLLSCFAVMGVPEKIKTDNGPGYCSKAFQKFLSQWKISHTTGIPYNSQGQAIVERTNRTLKTQLVKQKEGGDSKECTTPQMQLNLALYTLNFLNIYRNQTTTSAEQHLTGKKNSPHEGKLIWWKDNKNKTWEIGKVITWGRGFACVSPGENQLPVWIPTRHLKFYNEPIGDAKKRASTEMVTPVTWMDNPIEIYVNDSVWVPGPIDDRCPAKPEEEGMMINISIGYRYPPICLGRAPGCLMPAVQNWLVEVPTVSPISRFTYHMVSGMSLRPRVNYLQDFSYQRSLKFRPKGKPCPKEIPKESKNTEVLVWEECVANSAVILQNNEFGTIIDWAPRGQFYHNCSGQTQSCPSAQVSPAVDSDLTESLDKHKHKKLQSFYPWEWGEKGISTPRPKIVSPVSGPEHPELWRLTVASHHIRIWSGNQTLETRDCKPFYTIDLNSSLTVPLQSCVKPPYMLVVGNIVIKPDSQTITCENCRLLTCIDSTFNWQHRILLVRAREGVWIPVSMDRPWEASPSVHILTEVLKGVLNRSKRFIFTLIAVIMGLIAVTATAAVAGVALHSSVQSVNFVNDWQKNSTRLWNSQSSIDQKLANQINDLRQTVIWMGDRLMSLEHRFQLQCDWNTSDFCITPQIYNESEHHWDMVRRHLQGREDNLTLDISKLKEQIFEASKAHLNLVPGTEAIAGVADGLANLNPVTWVKTIGSTTIINLILILVCLFCLLLVCRCTQQLRRDSDHRERAMMTMAVLSKRKGGNVGKSKRDQIVTVSV(SEQ ID NO:1).

The Sequence ERV_0308616, With Sequence

MDDQLNQLFNLLQQTVRKRNFPFYITHIRAHTNLPGPLTKANEPADLLVSSAFIKAQKFHALTHVNAAGLKNKFDVTWKQAKDIVRHCTQCQVLHLPTQEAGVNPRGLCPNALRQMDVTHSKAFQKFLSQWKISHTTGIPYNSQGQAIVERTNRTLKTQLVKVPSFGRLLYVHVTVDTYSHFIWATCQTGESTSHVKKHLLPCFAVMRVPEKIKTDNGAGYC(SEQ ID NO:2),

shows 96% homology with the Pol sequence of the Member 6 of HERV-K (aa537-716; https://www.uniprot.org/uniprot/Q9BXR3) with sequence

MDDQLNQLFNLLQQTVRKRNFPFYITHIRAHTNLPGPLTKANEQADLLVSSALIKAQELHALTHVNAAGLKNKFDVTWKQAKDIVQHCTQCQVLHLPTQEAGVNPRGLCPNALWQMDVTHSKAFQKFLSQWKISHTTGIPYNSQGQAIVERTNRTLKTQLVKVPSFGRLSYVHVTVDTYSHFIWATCQTGESTSHVKKHLLSCFAVMGVPEKIKTDNGPGYC(SEQ ID NO:3).

Prediction of HERVs Epitopes

The Pol sequences identified in the HCC samples (SEQ ID NO: 1 and SEQ IDNO: 2) were used for the prediction of 9 amino acid epitopes byNetMHCpan version 4.0. Antigens were selected for each class I HLA withpredicted affinity <100 nM, corresponding to strong binders (SB). Below,in Table 3, the sequences of the predicted HERV epitopes or peptides arereported, together with the references SEQ ID NO.

Peptides common to all three analyzed sequences are highlighted in boldtype.

TABLE 3 SEQ ID NO: ID HLA PEPTIDE SCORE AFF(nM) %RANK BINDLEVEL 4ERV_312447 HLA-B*40:01 AELVAVITV 0.65 43.40 0.12 SB 4 ERV_312445HLA-B*40:01 AELVAVITV 0.65 43.40 0.12 SB 4 ERV_0308616 HLA-B*40:01AELVAVITV 0.65 43.40 0.12 SB 5 ERV_312447 HLA-A*02:01 AMIPKDWPL 0.854.80 0.03 SB 5 ERV_312445 HLA-A*02:01 AMIPKDWPL 0.85 4.80 0.03 SB 6ERV_312447 HLA-B*15:01 AMSNLFSIL 0.61 64.60 0.35 SB 6 ERV_312445HLA-B*15:01 AMSNLFSIL 0.61 64.60 0.35 SB 7 ERV_312447 HLA-B*15:01AQAITGVVL 0.59 81.40 0.44 SB 7 ERV_312445 HLA-B*15:01 AQAITGVVL 0.5981.40 0.44 SB 8 ERV_312447 HLA-B*15:01 AQINRIDPL 0.59 88.50 0.47 SB 8ERV_312445 HLA-B*15:01 AQINRIDPL 0.59 88.50 0.47 SB 9 ERV_312447HLA-B*27:05 ARYKSFSIK 0.58 90.20 0.30 SB 9 ERV_312445 HLA-B*27:05ARYKSFSIK 0.58 90.20 0.30 SB 10 ERV_0308616 HLA-B*07:02 ATRDVKTAL 0.6079.70 0.25 SB 11 ERV_312447 HLA-A*02:01 AVIMGLIAV 0.66 37.60 0.49 SB 11ERV_312445 HLA-A*02:01 AVIMGLIAV 0.66 37.60 0.49 SB 12 ERV_312447HLA-B*15:01 AVNAVIQPM 0.58 89.60 0.48 SB 12 ERV_312445 HLA-B*15:01AVNAVIQPM 0.58 89.60 0.48 SB 13 ERV_312447 HLA-A*02:01 AVQNWLVEV 0.7122.20 0.30 SB 13 ERV_312445 HLA-A*02:01 AVQNWLVEV 0.71 22.20 0.30 SB 14ERV_312447 HLA-B*58:01 CLMPAVQNW 0.71 23.80 0.16 SB 14 ERV_312445HLA-B*58:01 CLMPAVQNW 0.71 23.80 0.16 SB 15 ERV_312447 HLA-B*08:01EARYKSFSI 0.69 29.40 0.05 SB 15 ERV_312445 HLA-B*08:01 EARYKSFSI 0.6929.40 0.05 SB 16 ERV_312447 HLA-B*39:01 ERAMMTMAV 0.62 58.40 0.06 SB 16ERV_312445 HLA-B*39:01 ERAMMTMAV 0.62 58.40 0.06 SB 17 ERV_312447HLA-A*02:01 FINSGAWQI 0.75 14.50 0.18 SB 17 ERV_312445 HLA-A*02:01FINSGAWQI 0.75 14.50 0.18 SB 17 ERV_0308616 HLA-A*02:01 FINSGAWQI 0.7514.50 0.18 SB 18 ERV_312447 HLA-B*08:01 FLKLTTWIL 0.65 45.80 0.08 SB 18ERV_312445 HLA-B*08:01 FLKLTTWIL 0.65 45.80 0.08 SB 18 ERV_0308616HLA-B*08:01 FLKLTTWIL 0.65 45.80 0.08 SB 19 ERV_312447 HLA-A*02:01FLQAEVANA 0.75 14.80 0.18 SB 19 ERV_312445 HLA-A*02:01 FLQAEVANA 0.7514.80 0.18 SB 20 ERV_312447 HLA-A*02:01 FLQFKTWWI 0.83 6.30 0.05 SB 20ERV_312445 HLA-A*02:01 FLQFKTWWI 0.83 6.30 0.05 SB 21 ERV_312447HLA-A*01:01 FSDCYIIHY 0.82 7.00 0.01 SB 21 ERV_312445 HLA-A*01:01FSDCYIIHY 0.82 7.00 0.01 SB 22 ERV_312447 HLA-B*58:01 FSYQRSLKF 0.6264.10 0.35 SB 22 ERV_312447 HLA-B*15:01 FSYQRSLKF 0.67 35.40 0.17 SB 22ERV_312445 HLA-B*58:01 FSYQRSLKF 0.62 64.10 0.35 SB 22 ERV_312445HLA-B*15:01 FSYQRSLKF 0.67 35.40 0.17 SB 23 ERV_312447 HLA-A*26:01FTYHMVSGM 0.66 39.10 0.02 SB 23 ERV_312445 HLA-A*26:01 FTYHMVSGM 0.6639.10 0.02 SB 24 ERV_312447 HLA-A*02:01 FVGRALQPV 0.74 16.90 0.22 SB 24ERV_312445 HLA-A*02:01 FVGRALQPV 0.74 16.90 0.22 SB 25 ERV_312447HLA-B*40:01 GENQLPVWI 0.60 73.00 0.20 SB 25 ERV_312445 HLA-B*40:01GENQLPVWI 0.60 73.00 0.20 SB 26 ERV_312447 HLA-B*08:01 HLKKNCPVL 0.5985.30 0.15 SB 26 ERV_312445 HLA-B*08:01 HLKKNCPVL 0.59 85.30 0.15 SB 27ERV_0308616 HLA-B*15:01 HLLPCFAVM 0.60 72.60 0.39 SB 27 ERV_312447HLA-B*15:01 HLLSCFAVM 0.62 59.30 0.32 SB 27 ERV_312445 HLA-B*15:01HLLSCFAVM 0.62 59.30 0.32 SB 28 ERV_312447 HLA-B*07:02 HPELWRLTV 0.6641.30 0.15 SB 28 ERV_312445 HLA-B*07:02 HPELWRLTV 0.66 41.30 0.15 SB 29ERV_312447 HLA-B*39:01 HRERAMMTM 0.62 62.40 0.07 SB 29 ERV_312445HLA-B*39:01 HRERAMMTM 0.62 62.40 0.07 SB 30 ERV_312447 HLA-B*27:05HRILLVRAR 0.67 36.80 0.10 SB 30 ERV_312445 HLA-B*27:05 HRILLVRAR 0.6736.80 0.10 SB 31 ERV_312447 HLA-B*40:01 IEIYVNDSV 0.61 67.90 0.19 SB 31ERV_312445 HLA-B*40:01 IEIYVNDSV 0.61 67.90 0.19 SB 32 ERV_0308616HLA-B*08:01 IKAQKFHAL 0.58 97.50 0.17 SB 33 ERV_312447 HLA-A*02:01ILTEVLKGV 0.76 14.10 0.17 SB 33 ERV_312445 HLA-A*02:01 ILTEVLKGV 0.7614.10 0.17 SB 34 ERV_312447 HLA-B*07:02 IPTYAMSNL 0.62 64.10 0.21 SB 34ERV_312445 HLA-B*07:02 IPTYAMSNL 0.62 64.10 0.21 SB 35 ERV_312447HLA-B*15:01 IQTSTPFHY 0.61 71.70 0.39 SB 35 ERV_312445 HLA-B*15:01IQTSTPFHY 0.61 71.70 0.39 SB 36 ERV_312447 HLA-B*15:01 ISHTTGIPY 0.6640.30 0.20 SB 36 ERV_312445 HLA-B*15:01 ISHTTGIPY 0.66 40.30 0.20 SB 36ERV_0308616 HLA-B*15:01 ISHTTGIPY 0.66 40.30 0.20 SB 37 ERV_312447HLA-B*58:01 KAMLMAQAI 0.62 59.70 0.33 SB 37 ERV_312445 HLA-B*58:01KAMLMAQAI 0.62 59.70 0.33 SB 38 ERV_312447 HLA-B*40:01 KESKNTEVL 0.6927.80 0.07 SB 38 ERV_312445 HLA-B*40:01 KESKNTEVL 0.69 27.80 0.07 SB 39ERV_312447 HLA-A*02:01 KLIDCYTFL 0.84 5.60 0.04 SB 39 ERV_312445HLA-A*02:01 KLIDCYTFL 0.84 5.60 0.04 SB 40 ERV_312447 HLA-A*03:01KLIWWKDNK 0.63 53.10 0.20 SB 40 ERV_312445 HLA-A*03:01 KLIWWKDNK 0.6353.10 0.20 SB 41 ERV_312447 HLA-A*02:01 KLKEQIFEA 0.72 19.80 0.27 SB 41ERV_312445 HLA-A*02:01 KLKEQIFEA 0.72 19.80 0.27 SB 42 ERV_312447HLA-A*02:01 KLLGDINWI 0.81 8.00 0.08 SB 42 ERV_312445 HLA-A*02:01KLLGDINWI 0.81 8.00 0.08 SB 43 ERV_312447 HLA-A*03:01 KLTTWILPK 0.7810.90 0.02 SB 43 ERV_312445 HLA-A*03:01 KLTTWILPK 0.78 10.90 0.02 SB 43ERV_0308616 HLA-A*03:01 KLTTWILPK 0.78 10.90 0.02 SB 44 ERV_312447HLA-B*07:02 KPLKGKVPA 0.63 53.20 0.18 SB 44 ERV_312445 HLA-B*07:02KPLKGKVPA 0.63 53.20 0.18 SB 45 ERV_312447 HLA-B*15:01 KQYGPNSPY 0.799.30 0.02 SB 45 ERV_312445 HLA-B*15:01 KQYGPNSPY 0.79 9.30 0.02 SB 46ERV_312447 HLA-B*27:05 KRFIFTLIA 0.58 93.20 0.31 SB 46 ERV_312445HLA-B*27:05 KRFIFTLIA 0.58 93.20 0.31 SB 47 ERV_312447 HLA-A*03:01KSFSIKMLK 0.78 10.50 0.02 SB 47 ERV_312445 HLA-A*03:01 KSFSIKMLK 0.7810.50 0.02 SB 48 ERV_312447 HLA-B*58:01 KSSLSPSQF 0.67 34.80 0.22 SB 48ERV_312445 HLA-B*58:01 KSSLSPSQF 0.67 34.80 0.22 SB 49 ERV_0308616HLA-B*58:01 KTALIKYSM 0.62 62.50 0.34 SB 50 ERV_312447 HLA-A*03:01KTKIFQFLK 0.71 22.40 0.06 SB 50 ERV_312445 HLA-A*03:01 KTKIFQFLK 0.7122.40 0.06 SB 50 ERV_0308616 HLA-A*03:01 KTKIFQFLK 0.71 22.40 0.06 SB 51ERV_312447 HLA-B*15:01 KVIVELMAY 0.62 63.70 0.34 SB 51 ERV_312445HLA-B*15:01 KVIVELMAY 0.62 63.70 0.34 SB 52 ERV_312447 HLA-B*58:01LANLNPVTW 0.82 7.00 0.03 SB 53 ERV_312447 HLA-B*15:01 LLTCIDSTF 0.6640.00 0.20 SB 53 ERV_312445 HLA-B*15:01 LLTCIDSTF 0.66 40.00 0.20 SB 54ERV_0308616 HLA-A*03:01 LLVSSAFIK 0.61 66.60 0.25 SB 54 ERV_312447HLA-A*03:01 LLVSSALIK 0.62 63.50 0.24 SB 54 ERV_312445 HLA-A*03:01LLVSSALIK 0.62 63.50 0.24 SB 55 ERV_312447 HLA-A*02:01 LMAQAITGV 0.817.50 0.08 SB 55 ERV_312445 HLA-A*02:01 LMAQAITGV 0.81 7.50 0.08 SB 56ERV_312447 HLA-B*07:02 LPHSTVKTF 0.60 79.00 0.25 SB 56 ERV_312445HLA-B*07:02 LPHSTVKTF 0.60 79.00 0.25 SB 57 ERV_312447 HLA-B*07:02LPKQKLEAL 0.74 17.30 0.06 SB 57 ERV_312447 HLA-B*08:01 LPKQKLEAL 0.7219.90 0.03 SB 57 ERV_312445 HLA-B*07:02 LPKQKLEAL 0.74 17.30 0.06 SB 57ERV_312445 HLA-B*08:01 LPKQKLEAL 0.72 19.90 0.03 SB 58 ERV_312447HLA-B*15:01 LQSCVKPPY 0.70 25.70 0.12 SB 58 ERV_312445 HLA-B*15:01LQSCVKPPY 0.70 25.70 0.12 SB 59 ERV_312447 HLA-B*58:01 LQSFYPWEW 0.6830.40 0.20 SB 59 ERV_312445 HLA-B*58:01 LQSFYPWEW 0.68 30.40 0.20 SB 60ERV_312447 HLA-A*24:02 LYLDQIATL 0.58 98.90 0.21 SB 60 ERV_312445HLA-A*24:02 LYLDQIATL 0.58 98.90 0.21 SB 61 ERV_312447 HLA-A*24:02LYTLNFLNI 0.64 50.80 0.12 SB 61 ERV_312445 HLA-A*24:02 LYTLNFLNI 0.6450.80 0.12 SB 62 ERV_312447 HLA-A*03:01 MMINISIGY 0.62 60.40 0.23 SB 62ERV_312447 HLA-B*15:01 MMINISIGY 0.81 8.20 0.01 SB 62 ERV_312445HLA-A*03:01 MMINISIGY 0.62 60.40 0.23 SB 62 ERV_312445 HLA-B*15:01MMINISIGY 0.81 8.20 0.01 SB 63 ERV_312447 HLA-A*03:01 MMTMAVLSK 0.7219.90 0.05 SB 63 ERV_312445 HLA-A*03:01 MMTMAVLSK 0.72 19.90 0.05 SB 64ERV_312447 HLA-B*39:01 NRIDPLAPL 0.76 13.50 0.01 SB 64 ERV_312445HLA-B*39:01 NRIDPLAPL 0.76 13.50 0.01 SB 65 ERV_312447 H LA-A*24:02PYMLVVGNI 0.61 66.00 0.15 SB 65 ERV_312445 HLA-A*24:02 PYMLVVGNI 0.6166.00 0.15 SB 66 ERV_312447 HLA-B*58:01 QAFINSGAW 0.70 26.40 0.18 SB 66ERV_312445 HLA-B*58:01 QAFINSGAW 0.70 26.40 0.18 SB 66 ERV_0308616HLA-B*58:01 QAFINSGAW 0.70 26.40 0.18 SB 67 ERV_312447 HLA-B*07:02QPGLPSPAM 0.64 46.80 0.16 SB 67 ERV_312445 HLA-B*07:02 QPGLPSPAM 0.6446.80 0.16 SB 68 ERV_312447 HLA-B*58:01 QSVNFVNDW 0.75 15.00 0.10 SB 68ERV_312445 HLA-B*58:01 QSVNFVNDW 0.75 15.00 0.10 SB 69 ERV_312447HLA-B*07:02 RAMMTMAVL 0.67 33.90 0.12 SB 69 ERV_312447 HLA-B*58:01RAMMTMAVL 0.63 53.70 0.30 SB 69 ERV_312445 HLA-B*07:02 RAMMTMAVL 0.6733.90 0.12 SB 69 ERV_312445 HLA-B*58:01 RAMMTMAVL 0.63 53.70 0.30 SB 70ERV_312447 HLA-B*40:01 REDNLTLDI 0.61 64.50 0.18 SB 70 ERV_312445HLA-B*40:01 REDNLTLDI 0.61 64.50 0.18 SB 71 ERV_312447 HLA-B*58:01RGLCPNALW 0.76 13.90 0.09 SB 71 ERV_312445 HLA-B*58:01 RGLCPNALW 0.7613.90 0.09 SB 72 ERV_312447 HLA-A*03:01 RILTPEATK 0.64 49.80 0.19 SB 72ERV_312445 HLA-A*03:01 RILTPEATK 0.64 49.80 0.19 SB 73 ERV_312447HLA-A*02:01 RLIPYDWEI 0.88 3.70 0.02 SB 73 ERV_312445 HLA-A*02:01RLIPYDWEI 0.88 3.70 0.02 SB 74 ERV_0308616 HLA-A*02:01 RLLYVHVTV 0.7024.70 0.34 SB 75 ERV_312447 HLA-B*15:01 RLMSLEHRF 0.61 67.00 0.36 SB 75ERV_312445 HLA-B*15:01 RLMSLEHRF 0.61 67.00 0.36 SB 76 ERV_312447HLA-A*02:01 RLSYVHVTV 0.73 18.10 0.24 SB 76 ERV_312445 HLA-A*02:01RLSYVHVTV 0.73 18.10 0.24 SB 77 ERV_312447 HLA-A*02:01 RMLTDLRAV 0.7220.40 0.28 SB 77 ERV_312445 HLA-A*02:01 RMLTDLRAV 0.72 20.40 0.28 SB 78ERV_312447 HLA-B*07:02 RPWEASPSV 0.70 26.60 0.10 SB 78 ERV_312445HLA-B*07:02 RPWEASPSV 0.70 26.60 0.10 SB 79 ERV_0308616 HLA-B*27:05RRAELVAVI 0.68 32.60 0.07 SB 80 ERV_312447 HLA-B*27:05 RRNRLSFLG 0.6165.30 0.22 SB 80 ERV_312445 HLA-B*27:05 RRNRLSFLG 0.61 65.30 0.22 SB 81ERV_312447 HLA-A*03:01 RTLKTQLVK 0.65 45.50 0.17 SB 81 ERV_312445HLA-A*03:01 RTLKTQLVK 0.65 45.50 0.17 SB 81 ERV_0308616 HLA-A*03:01RTLKTQLVK 0.65 45.50 0.17 SB 82 ERV_312447 HLA-B*08:01 SLRPRVNYL 0.7514.30 0.01 SB 82 ERV_312445 HLA-B*08:01 SLRPRVNYL 0.75 14.30 0.01 SB 83ERV_312447 HLA-A*02:01 SMDDQLNQL 0.72 21.60 0.30 SB 83 ERV_312445HLA-A*02:01 SMDDQLNQL 0.72 21.60 0.30 SB 83 ERV_0308616 HLA-A*02:01SMDDQLNQL 0.72 21.60 0.30 SB 84 ERV_312447 HLA-A*26:01 STVKTFTLY 0.6833.30 0.02 SB 84 ERV_312447 HLA-B*15:01 STVKTFTLY 0.62 60.40 0.32 SB 84ERV_312445 HLA-A*26:01 STVKTFTLY 0.68 33.30 0.02 SB 84 ERV_312445HLA-B*15:01 STVKTFTLY 0.62 60.40 0.32 SB 85 ERV_312447 HLA-B*58:01TCIDSTFNW 0.67 36.10 0.23 SB 85 ERV_312445 HLA-B*58:01 TCIDSTFNW 0.6736.10 0.23 SB 86 ERV_312447 HLA-B*39:01 THIRAHTNL 0.62 60.90 0.07 SB 86ERV_312445 HLA-B*39:01 THIRAHTNL 0.62 60.90 0.07 SB 86 ERV_0308616HLA-B*39:01 THIRAHTNL 0.62 60.90 0.07 SB 87 ERV_312447 HLA-A*02:01TLIAVIMGL 0.77 12.40 0.15 SB 87 ERV_312445 HLA-A*02:01 TLIAVIMGL 0.7712.40 0.15 SB 88 ERV_312447 HLA-B*08:01 TVRKRNFPF 0.68 31.30 0.05 SB 88ERV_312445 HLA-B*08:01 TVRKRNFPF 0.68 31.30 0.05 SB 88 ERV_0308616HLA-B*08:01 TVRKRNFPF 0.68 31.30 0.05 SB 89 ERV_312447 HLA-B*58:01VASHHIRIW 0.70 26.90 0.18 SB 89 ERV_312445 HLA-B*58:01 VASHHIRIW 0.7026.90 0.18 SB 90 ERV_312447 HLA-B*40:01 VEVPTVSPI 0.62 60.20 0.17 SB 90ERV_312445 HLA-B*40:01 VEVPTVSPI 0.62 60.20 0.17 SB 91 ERV_312447HLA-B*15:01 VTVDTYSHF 0.64 50.20 0.25 SB 91 ERV_312445 HLA-B*15:01VTVDTYSHF 0.64 50.20 0.25 SB 91 ERV_0308616 HLA-B*15:01 VTVDTYSHF 0.6450.20 0.25 SB 92 ERV_312447 HLA-B*40:01 WEASPSVHI 0.66 41.70 0.12 SB 92ERV_312445 HLA-B*40:01 WEASPSVHI 0.66 41.70 0.12 SB 93 ERV_312447HLA-B*40:01 WEILAKSSL 0.78 10.30 0.01 SB 93 ERV_312445 HLA-B*40:01WEILAKSSL 0.78 10.30 0.01 SB 94 ERV_312447 HLA-A*01:01 WMDNPIEIY 0.6355.90 0.05 SB 94 ERV_312445 HLA-A*01:01 WMDNPIEIY 0.63 55.90 0.05 SB 95ERV_312447 HLA-A*02:01 WMGDRLMSL 0.77 12.30 0.15 SB 95 ERV_312447HLA-B*08:01 WMGDRLMSL 0.76 13.90 0.01 SB 95 ERV_312445 HLA-A*02:01WMGDRLMSL 0.77 12.30 0.15 SB 95 ERV_312445 HLA-B*08:01 WMGDRLMSL 0.7613.90 0.01 SB 96 ERV_312447 HLA-A*02:01 WQIGLANFV 0.69 28.50 0.39 SB 96ERV_312445 HLA-A*02:01 WQIGLANFV 0.69 28.50 0.39 SB 96 ERV_0308616HLA-A*02:01 WQIGLANFV 0.69 28.50 0.39 SB 97 ERV_312447 HLA-A*03:01WVNQWPLPK 0.60 73.70 0.28 SB 97 ERV_312445 HLA-A*03:01 WVNQWPLPK 0.6073.70 0.28 SB 98 ERV_312447 HLA-A*02:01 YAMSNLFSI 0.84 5.50 0.04 SB 98ERV_312447 HLA-B*39:01 YAMSNLFSI 0.65 43.30 0.04 SB 98 ERV_312447HLA-B*58:01 YAMSNLFSI 0.64 47.10 0.27 SB 98 ERV_312445 HLA-A*02:01YAMSNLFSI 0.84 5.50 0.04 SB 98 ERV_312445 HLA-B*39:01 YAMSNLFSI 0.6543.30 0.04 SB 98 ERV_312445 HLA-B*58:01 YAMSNLFSI 0.64 47.10 0.27 SB 99ERV_312447 HLA-B*39:01 YHMVSGMSL 0.88 3.60 0.00 SB 99 ERV_312445HLA-B*39:01 YHMVSGMSL 0.88 3.60 0.00 SB 100 ERV_312447 HLA-A*02:01YIDDILCAA 0.70 25.80 0.35 SB 100 ERV_312445 HLA-A*02:01 YIDDILCAA 0.7025.80 0.35 SB 101 ERV_312447 HLA-A*02:01 YLDQIATLI 0.79 10.20 0.12 SB101 ERV_312445 HLA-A*02:01 YLDQIATLI 0.79 10.20 0.12 SB 102 ERV_312447HLA-B*08:01 YPKTKIFQF 0.65 42.70 0.07 SB 102 ERV_312445 HLA-B*08:01YPKTKIFQF 0.65 42.70 0.07 SB 102 ERV_0308616 HLA-B*08:01 YPKTKIFQF 0.6542.70 0.07 SB 103 ERV_312447 HLA-B*07:02 YPQPPTRRL 0.73 19.20 0.07 SB103 ERV_312445 HLA-B*07:02 YPQPPTRRL 0.73 19.20 0.07 SB 104 ERV_0308616HLA-B*08:01 YQLARRAEL 0.66 41.50 0.07 SB 104 ERV_0308616 HLA-B*39:01YQLARRAEL 0.62 60.60 0.07 SB 105 ERV_312447 HLA-B*39:01 YQSAQRAEL 0.6737.30 0.03 SB 105 ERV_312445 HLA-B*39:01 YQSAQRAEL 0.67 37.30 0.03 SB106 ERV_312447 HLA-B*39:01 YQYWPPAEL 0.78 11.20 0.01 SB 106 ERV_312445HLA-B*39:01 YQYWPPAEL 0.77 11.20 0.01 SB 107 ERV_312447 HLA-B*15:01YVHVTVDTY 0.62 60.50 0.32 SB 107 ERV_312445 HLA-B*15:01 YVHVTVDTY 0.6260.50 0.32 SB 107 ERV_0308616 HLA-B*15:01 YVHVTVDTY 0.62 60.50 0.32 SBSEQ ID NO = peptide sequence progressive number; ID = ERV identificationnumber; HLA = HLA used for peptide prediction; PEPTIDE = peptidesequence; SCORE = The raw prediction score; AFF(nM) = affinity of thepeptide to the HLA, expressed in nM; %RANK = Rank of the predictedbinding score compared to a set of random natural peptides; BINDLEVEL =The peptide is identified as a strong binder if the %Rank is below 0.5%

Affinity and Stability Assays of Peptides to HLA * 02: 01

It was possible to experimentally verify the binding and stability ofthe predicted epitopes for the HLA-A * 0201 allele. The cell line T2positive for HLA A * 02 was used which, having a deficit in theintracellular processing of peptides, does not have epitopes on the cellsurface associated with HLA. Consequently, this cell line can be used toconfirm binding and binding stability of specific epitopes for such HLA.The experiments have shown that all the peptides predicted to bespecific for HLA * 02: 01 bind the allele and are presented on thesurface of T2 cells (FIG. 1 ). Furthermore, the dissociation kinetics ofthe peptide from HLA showed that all peptide-HLA complexes have adissociation value of 50% between 6 and 8 hours (T6 and T8), whichindicates a strong bond stability. This was observed for the predictedpeptides specific for HLA-A * 02: 01 and not for those specific forother HLA-A (FIG. 2 ).

IFN_(γ) ELiSpot Assays with PBMCs from HCC Patients Positive forHLA-A*02:01 and For HLA-A *24:02

PBMCs from HCC patients positive for HLA-A*02:01 and for HLA-A*24:02were purified and reacted with peptides predicted to be specific for thetwo alleles. The result of the IFN_(γ) ELiSpot assay demonstrates thatpatients with HCC have a proportion of circulating T lymphocytes capableof recognizing only the HERVs peptides predicted for HLA*02:01 andHLA-A*24:02 (FIG. 3 ).

Example 2. Bioinformatic Analysis to Identify HCC-Specific OverexpressedProteins Identification of HCC-Related Proteins for TAA Identification

In order to identify proteins specifically overexpressed in HCC and notdetected in normal liver cells, the Normal Tissue dataset available atthe Human Protein Atlas (https://www.proteinatlas.org/about/download)was interrogated. More than 15.000 proteins were screened and 5446 ofthem were found not detected into hepatocytes and bile duct cells ofnormal liver. In order to evaluate if those proteins were expressed inliver tumor, the Pathology dataset was analyzed and a total of 3283proteins were found to be expressed in the liver tumor samples, atdifferent levels. In particular, only a discrete number of such proteinsshows high expression in more than one sample of the Protein Atlas (310,9.45%) while the vast majority of them shows high expression in one orno sample at all (2973, 90.55%) (FIG. 4 ). To verify thetumor-specificity of such proteins, Normal Tissue dataset wasre-examined to exclude the expression of these proteins in all othernormal cells. The analysis identified 40 proteins with differentexpression levels in HCC that were absent in all normal tissues (Table4).

TABLE 4 Expression levels of each protein in liver cancer as defined inthe Human Protein Atlas(https://www.proteinatlas.org/humanproteome/pathology) Protein nameUNIPROT ID LIVER CANCER EXPRESSION LEVELS Normal Tissues expressionlevels* High Medium Low Not detected ISG15 P05161 9 2 0 0 NOT DET KLC1Q07866 8 3 0 0 NOT DET CAPN7 Q9Y6W3 7 3 0 2 NOT DET SERPINF2 P08697 6 41 1 NOT DET ORM1 P02763 5 5 1 1 NOT DET ORM2 P19652 5 5 1 1 NOT DETSEMA3A Q14563 5 7 0 0 NOT DET FGF17 O60258 5 4 0 3 NOT DET IL1R2 P279305 7 0 0 NOT DET MASP2 000187 5 4 3 0 NOT DET ANGPT2 015123 4 2 2 3 NOTDET CLEC3B P05452 4 1 2 2 NOT DET ADAMTSL2 Q86TH1 3 3 2 4 NOT DET AFPP02771 3 5 3 0 NOT DET APOC2 P02655 3 5 0 4 NOT DET C4BPA P04003 3 3 0 5NOT DET CFB P00751 3 7 1 0 NOT DET SERPINA7 P05543 3 7 1 0 NOT DETFAM186B Q8IYM0 3 3 2 4 NOT DET BMP6 P22004 2 8 0 0 NOT DET C7 P10643 2 91 0 NOT DET CRLF1 O75462 2 2 6 2 NOT DET F2 P00734 2 6 2 1 NOT DET LRG1P02750 2 6 1 1 NOT DET C1QTNF12 Q5T7M4 2 2 2 6 NOT DET MDK P21741 2 1 35 NOT DET APOC1 P02654 1 4 2 5 NOT DET CHRD Q9H2X0 1 9 1 1 NOT DET CPP00450 1 5 6 0 NOT DET DYRK4 Q9NR20 1 11 0 0 NOT DET ITIH4 Q14624 1 4 61 NOT DET PLTP P55058 1 10 1 0 NOT DET PON1 P27169 1 5 3 0 NOT DETTNFRSF1B P20333 1 8 2 0 NOT DET ADAMTS15 Q8TE58 1 7 2 2 NOT DET KLK14Q9P0G3 1 9 2 0 NOT DET PEBP4 Q96S96 1 4 4 3 NOT DET PI15 O43692 1 2 3 6NOT DET RGPD8 014715 1 4 2 4 NOT DET RSPO2 Q6UXX9 1 5 4 2 NOT DET*Normal tissue data from The Human Protein Atlashttps://www.proteinatlas.org/about/download

Survival Analysis

A survival analysis was performed for each of the selected 40 proteinsin order to identify those which are associated with a poor prognosis inHCC patients at a statistical significance. A total of 9 proteins wereidentified with such a characteristic (Table 5). The average 5-yearsurvival in HCC patients with high expression of all 9 proteins was34.33% compared to 53.88% in HCC patients with low expression (FIG. 5A).In particular, considering the high expression levels, the proteinassociated with the worst 5-year survival was DYRK4 (21%) and the oneassociated with the best survival was CAPN7 (41%) (FIGS. 5B and C).

TABLE 5 PROTEIN Best expression cut off-p score PROGNOSIS ISG15 0.041unfavorable KLC1 0.0012 unfavorable CAPN7 0.0022 unfavorable SEMA3A0.0029 unfavorable BMP6 0.0016 unfavorable C1QTNF12 (FAM132A) 0.0027unfavorable MDK 0.0057 unfavorable DYRK4 0.020 unfavorable PLTP 0.017unfavorable https://www.proteinatlas.org/

Gene Expression Analysis

The gene expression of the selected 9 proteins was assessed by RNASeqanalysis performed on 24 paired HCC samples and matched non tumoralliver tissues. The results showed a trend of a higher expression levelin cancer tissues for ISG15, CAPN7, SEMA3A and DYRK4 genes. The MDK geneshowed the most relevant increased expression in cancer tissues with a pvalue < 0.0001. On the contrary, KLC1, BMP6, C1QTNF12 and PLTP genesshowed higher expression levels in the normal tissues. In order toconfirm such results on a much larger dataset, we took advantage ofpublicly available data (http://gent2.appex.kr/gent2/). Gene expressionlevels from 691 liver cancer tissues were compare to 297 normal tissues.The analysis confirmed the data generated on the 24 HCC samples of ourcohort and were supported by high statistical p value, except for SEMA3Aand C1QTNF12 genes (FIGS. 6A and B). The gene expression levels did notshow a significant correlation with the protein expression reported atthe Protein Atlas, although the ISG15 gene was the one to show thehighest expression at both gene and protein.

Peptide Prediction

In order to identify potential tumor associated antigens (TAAs) derivedfrom the 9 overexpressed proteins associated with poor prognosis in HCC,the NetMHCpan software was used to predict 9 aa-long epitopes (nonamers)associated with the HLA-A*02:01 and 24:02 alleles. The number ofnonamers varied for each protein, according to the length of sequence,deriving from overlapping peptides along the protein with a shift of oneamino acid. Only a discrete number of strong (SB) and weak (WB) binderswere predicted for each protein associated with the two alleles (asdetermined with the algorithm NetMHCPanhttp://www.cbs.dtu.dk/services/NetMHCpan/). Overall, considering bothalleles, the MDK protein showed the lowest (3 SB and 2 WB) and the CAPN7protein showed the highest (25 SB and 47 WB) cumulative number ofbinders (Table 6). Among the SB, only those with a predicted affinitylower than 100 nM were selected and further subdivided in three groupscharacterized by affinity <10 nM, 10< affinity <50 nM, affinity >50 nM(FIG. 7 ). Indeed, only those with a predicted affinity <50 nM have beenpreviously shown to have a 100% concordance with ex vivo binding assay(Petrizzo et al., JTM 2018, Unique true predicted neoantigens (TPNAs)correlates with anti-tumor immune control in HCC patients. Petrizzo A,Tagliamonte M, Mauriello A, Costa V, Aprile M, Esposito R, Caporale A,Luciano A, Arra C, Tornesello ML, Buonaguro FM, Buonaguro L. J TranslMed. 2018 Oct 19;16(1):286. doi: 10.1186/s12967-018-1662-9. PMID:30340600). According to such a classification, 12 peptides with affinity<10 nM and 24 peptides with 10< affinity <50 nM were identified in bothHLA-A alleles (FIG. 7 ). The NetMHCstabpan software was used toimplement the prediction analysis with information on the bindingstability of the peptides to the HLA molecule, expressed as half lifetime in hours (Thalf) (Table 7). According to this combined analysis, ahandful number of predicted epitopes were classified as SB, with a Thalfranging from 1.96 hrs (the HLA-A*24:02 linked peptide VHMKDFFYF from theDYRK4 protein) to 61.9 hrs (the HLA-A*24:02 linked peptide VYSACSFTFfrom the CAPN7 protein) (Table 7).

TABLE 6 For each protein are indicated the number of strong binders (SB)and weak binders (WB) predicted to bind each of the two HLA. PROTEINHLA-A SB WB ISG15 HLA-A*02:01 5 8 HLA-A*24:02 0 3 MDK HLA-A*02:01 3 1HLA-A*24:02 0 1 KLC1 HLA-A*02:01 9 9 HLA-A*24:02 4 6 CAPN7 HLA-A*02:0110 20 HLA-A*24:02 15 27 SEMA3A HLA-A*02:01 5 7 HLA-A*24:02 8 33 BMP6HLA-A*02:01 5 13 HLA-A*24:02 3 11 C1QTNF12 HLA-A*02:01 5 10 HLA-A*24:022 5 DYRK4 HLA-A*02:01 2 11 HLA-A*24:02 7 18 PLTP HLA-A*02:01 7 22HLA-A*24:02 9 16

TABLE 7 For each protein are indicated the aminoacide sequence ofpeptide predicted to bind each of the two HLA. AFF = affinity of bindingto HLA expressed in nM; Thalf = stability of binding expressed in hours;Binder = strong binder (SB); weak binder (WB) according to theNetMHCstabpan predictive tool. HLA-A*02:01 HLA-A*24:02 PROTEIN SEQ AFFThalf Binder PROTEIN SEQ AFF Thalf Binder ISG15 MLAGNEFQV 4.35 5.22 SBGVQDDLFWL 69.76 0.7 WB ALQDRVPLA 70.13 3.09 WB RLAVHPSGV 82.29 4.73 WBRLTQTVAHL 90.38 6.75 WB MDK ALLALTSAV 10.06 9.85 SB LLLTLLALL 11.34 4.69WB FLLLTLLAL 17.89 5.1 WB KLC1 TMLNILALV 5.14 17.22 SB KLC1 YYYQRALEI12.69 4.06 SB ALSNHLNAV 10.73 18.84 SB VMMALSNHL 11.55 3.64 WB ILQSLLETL31.65 4.15 WB KLGPDDPNV 46.49 1.97 WB SLLETLKCL 53.81 3.24 WB KQLNNLALL62.31 1.95 WB GLSEAQVMM 93.94 1.08 WB CAPN7 RQYSVGFEV 18.12 3.19 SBCAPN7 VYSACSFTF 3.83 61.9 SB VIIDDQLPV 20.16 4.74 WB IYTVSSFSI 14.925.44 SB KITEYLERV 26.12 15.36 SB IFNIIPSTF 32.18 3.11 SB KIDNGIFWI 28.171.75 WB YYDVIYLSW 53.61 5.88 SB KQNTIHYTV 84.06 3.03 WB SEMA3A AMYNPVFPM8.47 2.41 WB SEMA3A VWYRDFMQL 63.51 0.6 WB TLLKVTLEV 10.07 5.76 SBLYSGTAADF 84.34 2.2 SB KLLTASLLI 13.26 3 WB LYACGTGAF 91.7 2.72 SBTMDEFCEQV 23.43 6.96 WB RIVCLFWGV 15.92 4.94 SB BMP6 FMLDLYNAL 3.7 3.17SB BMP6 KQPFMVAFF 43.81 0.57 WB MVMSFVNLV 4.72 11.07 SB FLNDADMVM 10.282.04 WB FLISIYQVL 11.1 4.82 SB C1QTNF12 FQFSASLHV 7.76 5.7 SB LLHEFQELL16.18 4.18 WB LLGPQLVLL 37.45 2.61 WB TLLHEFQEL 54.09 1.44 n/a DYRK4VILGHPYDV 62.7 1.88 WB DYRK4 FYFRNHFCI 12.53 22.36 SB SLGCITAEL 31.081.72 WB VYTYIQSRF 22.25 13.91 SB VHMKDFFYF 34.95 1.96 SB PLTP ALFGALFLA4.79 7.31 SB PLTP VYVAFSEFF 7.21 14.55 SB LLNSLLDTV 9.24 13.38 SBTYFGSIVLL 60.74 2.09 SB ALIPLQAPL 21.34 4.21 WB LYHAGTVLL 68.06 2.92 SBFLEQELETI 99.88 3.04 n/a TFITSGMRF 99.93 1.31 WB LLNQQICPV 10.28 34.15SB YINASAEGV 92.99 2.15 WB

Peptide Similarity to Pathogen Epitopes

Predicted strong binder epitopes were screened for homology to humanviral sequences in BLAST. Several peptides from a broad range of humanviruses were found to share high homology with those derived from theHCC proteins. However, only four of them were predicted to be strongbinders to HLA-A*0201 with a Thalf >3 hrs (Table 8). A predicted epitopederived from the Human Calicivirus showed 6/9 identical residues with anepitope from the ISG15. A predicted epitope derived from the HCV and onederived from the Human Adenovirus 4 showed 7/9 and 8/9 identicalresidues with two epitopes from the MDK. A predicted epitope derivedfrom the HBV showed 8/9 identical residues with an epitope from theC1QTNF12. Strikingly, the epitope derived from the HCV shows affinityand stability to the HLA-A*02:01 significantly higher than thecorresponding TAA (3.11 vs. 10.06 nM; 45.58 vs. 9.85 hours) (Table 8).Likewise, only three viral peptides were predicted to bind theHLA-A*2402 molecule but with low affinity (>70 nM) and/or low stability(<1.5 hrs) (Table 8).

TABLE 8 HLA PROTEIN SEQUENCE VIRAL PROTEIN AFF Thalf BINDING A*02:01ISG15 MLAGNEFQV 4.35 5.22 SB MLAGNAFTA capsid protein Human calicivirus13.86 3.53 WB MDK ALLALTSAV 10.06 9.85 SB ALMAFTSAV polyprotein HCV seqID: AID60264.1 3.11 45.58 SB MDK LLLTLLALL 11.34 4.69 WB LLLTLLLLL E314.5 kDa protein [Human adenovirus E4] Seq ID: AGT51280.1 17.75 4.41 WBC1QTNF12 LLGPQLVLL 37.45 2.61 WB LLGPLLVLL S protein HBV Seq ID:AUF41974.1 20.91 3.38 WB A*24:02 CAPN7 VYSACSFTF 3.83 61.9 SB GSPACTFTFprotein UL29 CMV Seq ID: 658.27 0.65 WB CAPN7 IYTVSSFSI 14.92 5.44 SBSYTVSSFQV nonstructural protein 1 [Influenza A virus] Seq ID: QEM33605.1352.63 1.06 WB DYRK4 FYFRNHFCI 12.53 22.36 SB DYFRNQFKI polymerase basicprotein 2 Influenza A virus Seq ID: AAV33795.1 77.75 1.39 WB

Epitope Modeling and Molecular Docking

In order to verify that predicted paired TAA and viral epitopes sharesimilar contact residues with both the HLA molecule and the TCR, epitopemodeling and molecular docking were performed for each paired peptides.This was possible only for HLA-A*0201 restricted epitopes, due to thelack of crystallized structures including both HLA and TCR for otheralleles deposited in the PDB. The 1AO7 crystallized complex includingthe HTLV-I TAX epitope was used as general template to conduct theanalyses. As example, the ISG15 MLAGNEFQV and the human calicivirusMLAGNAFTA peptides show a similar interacting pattern between theresidues of both peptides and the HLA as well as the β chain of the TCR.Differences are represented by the substitution of non-polar A with anegative-charged E in position 6 which substantially changes the contactpattern with the α chain of the TCR. Furthermore, the two additionalconservative polar (T8Q) and non polar (A9V) substitutions do not changethe contact pattern with the TCR (FIG. 8 ). This would suggest that theTCR clones targeting the two peptides would share only the same β chain.

The present invention relates to a mix comprising at least one peptidefrom the groups of peptides identified above, namely the HERV-TSAs andthe HCC-TAAs and peptides from human viruses with high homology withthose derived from the HCC proteins.

In particular, preferred peptides from the HERV-TSAs (Table 3) include:

1) FINSGAWQI (SEQ ID. NO 17)

2) KLTTWILPK (SEQ ID NO 43)

3) KTKIFQFLK (SEQ ID. NO 50)

4) PYMLVVGNI (SEQ ID. NO 65)

5) SMDDQLNQL (SEQ ID. NO 83)

6) WQIGLANFV (SEQ ID. NO 96).

Preferred peptides from the HCC-TAAs (Table 7) include:

1) Seq ISG15 MLAGNEFQV (SEQ ID. NO 108)

2) Seq KLC1 TMLNILALV (SEQ ID. NO 109)

3) Seq KLC1 YYYQRALEI (SEQ ID. NO 110)

4) Seq CAPN7 KITEYLERV (SEQ ID. NO 111)

5) Seq CAPN7 VYSACSFTF (SEQ ID. NO 112)

6) Seq SEMA3A TLLKVTLEV (SEQ ID. NO 113)

7) Seq SEMA3A LYSGTAADF (SEQ ID. NO 114)

8) Seq BMP6 MVMSFVNLV (SEQ ID. NO 115)

9) Seq DYRK4 FYFRNHFCI (SEQ ID. NO 116)

10) Seq PLTP LLNQQICPV (SEQ ID. NO 117)

11) Seq PLTP VYVAFSEFF (SEQ ID. NO 118)

Preferred peptides from the human viruses with high homology with thosederived from the HCC proteins (Table 8) include:

12) Seq ISG15 MLAGNAFTA (SEQ ID. NO 119)

13) Seq MDK ALMAFTSAV (SEQ ID. NO 120)

14) Seq DYRK4 DYFRNQFKI (SEQ ID. NO 121)

Further preferred peptides from the HCC-TAAs (Table 7) include:

15) Seq MDK ALLALTSAV (SEQ ID. NO 122)

16) Seq KLC1 ALSNHLNAV (SEQ ID. NO 123)

17) Seq CAPN7 RQYSVGFEV (SEQ ID. NO 124)

18) Seq CAPN7 IYTVSSFSI (SEQ ID. NO 125)

19) Seq CAPN7 IFNIIPSTF (SEQ ID. NO 126)

20) Seq CAPN7 YYDVIYLSW (SEQ ID. NO 127)

21) Seq SEMA3A RIVCLFWGV (SEQ ID. NO 128)

22) Seq SEMA3A LYACGTGAF (SEQ ID. NO 129)

23) Seq BMP6 FMLDLYNAL (SEQ ID. NO 130)

24) Seq BMP6 FLISIYQVL (SEQ ID. NO 131)

25) Seq C1QTNF12 FQFSASLHV (SEQ ID. NO 132)

26) Seq DYRK4 VYTYIQSRF (SEQ ID. NO 133)

27) Seq DYRK4 VHMKDFFYF (SEQ ID. NO 134)

28) Seq PLTP ALFGALFLA (SEQ ID. NO 135)

29) Seq PLTP LLNSLLDTV (SEQ ID. NO 136)

30) Seq PLTP TYFGSIVLL (SEQ ID. NO 137)

31) Seq PLTP LYHAGTVLL (SEQ ID. NO 138)

Further preferred peptides from the human viruses with high homologywith those derived from the HCC proteins (Table 8) include:

32) Seq MDK LLLTLLLLL (SEQ ID. NO 139)

33) Seq MDK LLGPLLVLL (SEQ ID. NO 140)

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1. A composition comprising at least a peptide or an expression vectorthat induces the expression of said at least one peptide, said peptideconsisting of an amino acid (aa) sequence from 9 to 30 aa residues andcomprising an epitope sequence selected from the group consisting of:MLAGNAFTA (SEQ ID NO. 119), ALMAFTSAV (SEQ ID NO. 120), DYFRNQFKI (SEQID NO. 121), MLAGNEFQV (SEQ ID NO. 108), TMLNILALV (SEQ ID NO. 109),YYYQRALEI (SEQ ID NO. 110), KITEYLERV (SEQ ID NO. 111), VYSACSFTF (SEQID NO. 112), TLLKVTLEV (SEQ ID NO. 113), LYSGTAADF (SEQ ID NO. 114),MVMSFVNLV (SEQ ID NO. 115), FYFRNHFCI (SEQ ID NO. 116), LLNQQICPV (SEQID NO. 117), and VYVAFSEFF (SEQ ID NO. 118), and a pharmaceuticallyacceptable vehicle or excipient.
 2. The composition according to claim 1wherein said epitope sequence is selected from the group consisting of:MLAGNAFTA (SEQ ID NO. 119), ALMAFTSAV (SEQ ID NO. 120), and DYFRNQFKI(SEQ ID NO. 121).
 3. The composition according to claim 1 furthercomprising or expressing a peptide consisting of an aa sequence of 9 to30 aa and comprising an epitope sequence selected from the groupconsisting of: ALLALTSAV (SEQ ID NO. 122), ALSNHLNAV (SEQ ID NO. 123),RQYSVGFEV (SEQ ID NO. 124), IYTVSSFSI (SEQ ID NO. 125), IFNIIPSTF (SEQID NO. 126), YYDVIYLSW (SEQ ID NO. 127), RIVCLFWGV (SEQ ID NO. 128),LYACGTGAF (SEQ ID NO. 129), FMLDLYNAL (SEQ ID NO. 130), FLISIYQVL (SEQID NO. 131), FQFSASLHV (SEQ ID NO. 132), VYTYIQSRF (SEQ ID NO. 133),VHMKDFFYF (SEQ ID NO. 134), ALFGALFLA (SEQ ID NO. 135), LLNSLLDTV (SEQID NO. 136), TYFGSIVLL (SEQ ID NO. 137), LYHAGTVLL (SEQ ID NO. 138),LLLTLLLLL (SEQ ID NO. 139), and LLGPLLVLL(SEQ ID NO. 140).
 4. Thecomposition according to claim 1 further comprising or expressing apeptide consisting of an aa sequence of 9 to 30 aa and comprising anepitope sequence selected from the group consisting of: FINSGAWQI (SEQID NO. 17), KLTTWILPK (SEQ ID NO. 43), KTKIFQFLK (SEQ ID NO. 50),PYMLVVGNI (SEQ ID NO. 65), SMDDQLNQL (SEQ ID NO. 83), WQIGLANFV (SEQ IDNO. 96).
 5. The composition according to claim 1 further comprising orexpressing a peptide of 9 to 30 amino acids comprising an epitopesequence selected from the group consisting of SEQ ID NO. 4-16, SEQ IDNO. 18-42, SEQ ID NO. 44-49, SEQ ID NO. 51-64, SEQ ID NO. 66-82, SEQ IDNO. 84-95 and SEQ ID NO. 97-107.
 6. The composition according to claim 4comprising: a. an epitope sequence selected from the group consistingof: MLAGNAFTA (SEQ ID NO. 119), ALMAFTSAV (SEQ ID NO. 120), DYFRNQFKI(SEQ ID NO. 121); and b. an epitope sequence selected from the groupconsisting of: MLAGNEFQV (SEQ ID NO. 108), TMLNILALV (SEQ ID NO. 109),YYYQRALEI (SEQ ID NO. 110), KITEYLERV (SEQ ID NO. 111), VYSACSFTF (SEQID NO. 112), TLLKVTLEV (SEQ ID NO. 113), LYSGTAADF (SEQ ID NO. 114),MVMSFVNLV (SEQ ID NO. 115), FYFRNHFCI (SEQ ID NO. 116), LLNQQICPV (SEQID NO. 117), VYVAFSEFF (SEQ ID NO. 118); and c. an epitope sequenceselected from the group consisting of: FINSGAWQI (SEQ ID NO. 17),KLTTWILPK (SEQ ID N0.43), KTKIFQFLK (SEQ ID NO. 50), PYMLVVGNI (SEQ IDNO. 65), SMDDQLNQL (SEQ ID NO. 83), WQIGLANFV (SEQ ID NO. 96).
 7. Thecomposition according to claim 1 wherein thepeptide consists of an aminoacid (aa) sequence from 9 to 20 aa residues.
 8. The compositionaccording to claim 1 wherein said peptide is bound or inserted into anantibody which is specific for dendritic cells.
 9. An engineered cellcomprising a recombinant protein, or a polynucleotide encoding arecombinant protein, a receptor, wherein the recombinant proteinspecifically binds to a least peptide of the composition.
 10. A methodfor the treatment and/or prevention of cancer, comprising administeringa composition of claim 1 to a patient in need of such treatment and/orprevention.
 11. The method according to claim 10, further comprisingadministering in combination a further anticancer therapeutic agent. 12.A vaccine or immunogenic composition comprising the composition of claim1 and a pharmaceutically acceptable vehicle or excipient.
 13. A methodfor the treatment and/or prevention of cancer, the vaccine orimmunogenic composition of claim 12 to a patient in need of suchtreatment and/or prevention.
 14. An isolated peptide selected from thegroup consisting of the peptides having aa sequences selected from SEQID NO. 4-140 or of the peptides having an aa sequence of 9 to 30 aa andcomprising at least one of SEQ ID NO 108-140, wherein said isolatedpeptide is able to bind MHC class I and/or MHC class II.
 15. The peptideaccording to claim 14 wherein said peptide is bound or inserted into anantibody which is specific for dendritic cells.
 16. The method of claim10, wherein the cancer is liver cancer.
 17. The method of claim 16,wherein the liver cancer is hepatocellular carcinoma.
 18. A method forthe treatment and/or prevention of cancer comprising administering theengineered cell of claim 9 to a patient in need of such treatment and/orprevention.
 19. The method of claim 18, wherein the cancer is livercancer.
 20. The method of claim 19, wherein the liver cancer ishepatocellular carcinoma.